Date published: 2025-10-12

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Caffeine (CAS 58-08-2)

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Alternate Names:
methyltheobromine; 1,3,7-Trimethylxantine; 1,3,7-Trimethyl-2,6-dioxopurine
Application:
Caffeine is an adenosine receptor antagonist and cAMP phosphodiesterase inhibitor
CAS Number:
58-08-2
Purity:
≥98%
Molecular Weight:
194.20
Molecular Formula:
C8H10N4O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Eukaryotic initiation factors (eIFs) are a crucial group of proteins involved in the initiation phase of protein translation in eukaryotic cells. This process, known as translation initiation, marks the beginning of protein synthesis, and it plays a central role in regulating gene expression. eIFs orchestrate the assembly of ribosomes on messenger RNA (mRNA) and the recruitment of transfer RNA (tRNA) molecules bearing amino acids, enabling the synthesis of polypeptide chains. This intricate process is highly regulated and essential for proper cellular function. One of the key events in translation initiation is the formation of the eIF complex known as the eIF4F complex, which consists of eIF4E, eIF4A, and eIF4G. eIF4E binds to the mRNA cap structure, eIF4A serves as an RNA helicase, and eIF4G acts as a scaffold protein facilitating the interaction between various translation factors. This complex plays a pivotal role in mRNA recruitment to ribosomes, allowing efficient translation to occur. Additionally, eIF2 is another critical factor in translation initiation, responsible for delivering the initiator tRNA to the ribosome′s P-site. (eukaryotic translation initiation factor) eIF inhibitors are a class of chemical compounds that target key components of the eIF signaling pathway, disrupting their normal functions and consequently impeding the initiation of protein translation. These inhibitors may act at various stages of translation initiation, including the inhibition of eIF4F complex formation, disruption of eIF2 function, or interference with RNA helicase activity. By interfering with these critical steps, eIF inhibitors can modulate the rate of protein synthesis, leading to global changes in gene expression.


Caffeine (CAS 58-08-2) References

  1. Caffeine's mechanisms of action and its cosmetic use.  |  Herman, A. and Herman, AP. 2013. Skin Pharmacol Physiol. 26: 8-14. PMID: 23075568
  2. Caffeine: cognitive and physical performance enhancer or psychoactive drug?  |  Cappelletti, S., et al. 2015. Curr Neuropharmacol. 13: 71-88. PMID: 26074744
  3. The neuroprotective effects of caffeine in neurodegenerative diseases.  |  Kolahdouzan, M. and Hamadeh, MJ. 2017. CNS Neurosci Ther. 23: 272-290. PMID: 28317317
  4. Caffeine, coffee, and appetite control: a review.  |  Schubert, MM., et al. 2017. Int J Food Sci Nutr. 68: 901-912. PMID: 28446037
  5. Administration of Caffeine in Alternate Forms.  |  Wickham, KA. and Spriet, LL. 2018. Sports Med. 48: 79-91. PMID: 29368182
  6. Caffeine in Kidney Stone Disease: Risk or Benefit?  |  Peerapen, P. and Thongboonkerd, V. 2018. Adv Nutr. 9: 419-424. PMID: 30032225
  7. What Should We Do About Habitual Caffeine Use in Athletes?  |  Pickering, C. and Kiely, J. 2019. Sports Med. 49: 833-842. PMID: 30173351
  8. Caffeine Intake Habits and the Perception of Its Effects on Health Among College Students.  |  Bucher, J., et al. 2019. Health Care Manag (Frederick). 38: 44-49. PMID: 30640237
  9. Caffeine and Exercise: What Next?  |  Pickering, C. and Grgic, J. 2019. Sports Med. 49: 1007-1030. PMID: 30977054
  10. [Caffeine, the most frequently consumed psychostimulant: a narrative review article].  |  Gahr, M. 2020. Fortschr Neurol Psychiatr. 88: 318-330. PMID: 31610604
  11. Effect of Caffeine Consumption on the Risk for Neurological and Psychiatric Disorders: Sex Differences in Human.  |  Jee, HJ., et al. 2020. Nutrients. 12: PMID: 33050315
  12. The Medicinal Chemistry of Caffeine.  |  Faudone, G., et al. 2021. J Med Chem. 64: 7156-7178. PMID: 34019396
  13. Effects of Caffeine and Caffeinated Beverages in Children, Adolescents and Young Adults: Short Review.  |  Soós, R., et al. 2021. Int J Environ Res Public Health. 18: PMID: 34886115

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Caffeine, 5 g

sc-202514
5 g
$32.00

Caffeine, 100 g

sc-202514A
100 g
$66.00

Caffeine, 250 g

sc-202514B
250 g
$95.00

Caffeine, 1 kg

sc-202514C
1 kg
$188.00

Caffeine, 5 kg

sc-202514D
5 kg
$760.00