Caffeine is a CNS stimulant that blocks Adenosine A1-R and Adenosine A2A-R. Caffeine is also a cAMP phosphodiesterase inhibitor. Caffeine interferes with the uptake and storage of Ca2+ by the sarcoplasmic reticulum in skeletal muscle and prevents apoptosis and cell cycle effects induced by various chemicals. Caffeine inhibits cellular DNA repair mechanism and displays anti-inflammatory properties. Caffeine is found in tea leaves, coffee beans, cocoa beans, matε leaves, guarana paste and kola nuts.
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