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D,L-Sulforaphane (CAS 4478-93-7)

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Alternate Names:
D,L-Sulforaphane also known as 1-Isothiocyanato-4-(methylsulfinyl)-butane; 4-Methylsulfinylbutyl Isothiocyanate; Sulforaphan; R,S-Sulforaphanesulforafan; sulforaphan; sulforaphane; R-SULFORAPHANE; R,S-SULFORAPHANE; SULFORAPHANE, L-; SULFORAPHANE, DL-; SULFORAPHANE, D-; S-SULFORAPHANE; (−)-(4R)-SULFORAPHANE; 4-METHYLSULFINYLBUTYL ISOTHIOCYANATE; 1-ISOTHISCYANATO-4-(METHYLSULFINYL)-BUTANE; 1-ISOTHIOCYANATO-4-(METHYLSULFINYL)-BUTANE; (−)1-ISOTHIOCYANATO-4S-(METHYLSULFINYL)-BUTANE; (+)1-ISOTHIOCYANATO-4S-(METHYLSULFINYL)-BUTANE
Application:
D,L-Sulforaphane is a selective inducer of phase II detoxification enzymes used for breast cancer research
CAS Number:
4478-93-7
Purity:
≥90%
Molecular Weight:
177.29
Molecular Formula:
C6H11NOS2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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D,L-Sulforaphane (SFN) is a potent and selective inducer of phase II detoxification enzymes with anticarcinogenic and anti-microbial properties. D,L-Sulforaphane acts as an antitumor agent that was found to inhibit chemically induced mammary tumor formation in rats. D,L-Sulforaphane increases the transcription of tumor suppressor proteins and inhibits histone deacetylases. D,L-Sulforaphane is an inhibitor of Aryl Hydrocarbon Receptor. D,L-Sulforaphane regulates inflammatory responses by suppressing the LPS-mediated expression of iNOS, COX-2, IL-1β and TNF-α.


D,L-Sulforaphane (CAS 4478-93-7) References

  1. A major inducer of anticarcinogenic protective enzymes from broccoli: isolation and elucidation of structure.  |  Zhang, Y., et al. 1992. Proc Natl Acad Sci U S A. 89: 2399-403. PMID: 1549603
  2. D,L-Sulforaphane-induced cell death in human prostate cancer cells is regulated by inhibitor of apoptosis family proteins and Apaf-1.  |  Choi, S., et al. 2007. Carcinogenesis. 28: 151-62. PMID: 16920735
  3. Pretreatment of human epidermal keratinocytes with D,L-sulforaphane protects against sulfur mustard cytotoxicity.  |  Gross, CL., et al. 2006. Cutan Ocul Toxicol. 25: 155-63. PMID: 16980241
  4. Induction of p21 protein protects against sulforaphane-induced mitotic arrest in LNCaP human prostate cancer cell line.  |  Herman-Antosiewicz, A., et al. 2007. Mol Cancer Ther. 6: 1673-81. PMID: 17513615
  5. D,L-Sulforaphane causes transcriptional repression of androgen receptor in human prostate cancer cells.  |  Kim, SH. and Singh, SV. 2009. Mol Cancer Ther. 8: 1946-54. PMID: 19584240
  6. Sulforaphane suppresses LPS-induced inflammation in primary rat microglia.  |  Brandenburg, LO., et al. 2010. Inflamm Res. 59: 443-50. PMID: 19924513
  7. Sulforaphane inhibits constitutive and interleukin-6-induced activation of signal transducer and activator of transcription 3 in prostate cancer cells.  |  Hahm, ER. and Singh, SV. 2010. Cancer Prev Res (Phila). 3: 484-94. PMID: 20233902
  8. Separation and purification of sulforaphane from broccoli by solid phase extraction.  |  Han, D. and Row, KH. 2011. Int J Mol Sci. 12: 1854-61. PMID: 21673926
  9. D,L-sulforaphane-induced apoptosis in human breast cancer cells is regulated by the adapter protein p66Shc.  |  Sakao, K. and Singh, SV. 2012. J Cell Biochem. 113: 599-610. PMID: 21956685
  10. Ciliopathy proteins regulate paracrine signaling by modulating proteasomal degradation of mediators.  |  Liu, YP., et al. 2014. J Clin Invest. 124: 2059-70. PMID: 24691443
  11. D, L-Sulforaphane Loaded Fe3O4@ Gold Core Shell Nanoparticles: A Potential Sulforaphane Delivery System.  |  Kheiri Manjili, H., et al. 2016. PLoS One. 11: e0151344. PMID: 26982588
  12. Aldo-keto reductases are biomarkers of NRF2 activity and are co-ordinately overexpressed in non-small cell lung cancer.  |  MacLeod, AK., et al. 2016. Br J Cancer. 115: 1530-1539. PMID: 27824809
  13. d,l-Sulforaphane Induces ROS-Dependent Apoptosis in Human Gliomablastoma Cells by Inactivating STAT3 Signaling Pathway.  |  Miao, Z., et al. 2017. Int J Mol Sci. 18: PMID: 28054986
  14. Anticarcinogenic activities of sulforaphane and structurally related synthetic norbornyl isothiocyanates.  |  Zhang, Y., et al. 1994. Proc Natl Acad Sci U S A. 91: 3147-50. PMID: 8159717

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

D,L-Sulforaphane, 5 mg

sc-207495A
5 mg
$153.00

D,L-Sulforaphane, 10 mg

sc-207495B
10 mg
$292.00

D,L-Sulforaphane, 25 mg

sc-207495C
25 mg
$489.00

D,L-Sulforaphane, 250 mg

sc-207495D
250 mg
$933.00

D,L-Sulforaphane, 1 g

sc-207495
1 g
$1325.00

D,L-Sulforaphane, 10 g

sc-207495E
10 g
$8465.00