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D,L-Sulforaphane (CAS 4478-93-7)

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Alternate Names:
D,L-Sulforaphane also known as 1-Isothiocyanato-4-(methylsulfinyl)-butane; 4-Methylsulfinylbutyl Isothiocyanate; Sulforaphan; R,S-Sulforaphanesulforafan; sulforaphan; sulforaphane; R-SULFORAPHANE; R,S-SULFORAPHANE; SULFORAPHANE, L-; SULFORAPHANE, DL-; SULFORAPHANE, D-; S-SULFORAPHANE; (−)-(4R)-SULFORAPHANE; 4-METHYLSULFINYLBUTYL ISOTHIOCYANATE; 1-ISOTHISCYANATO-4-(METHYLSULFINYL)-BUTANE; 1-ISOTHIOCYANATO-4-(METHYLSULFINYL)-BUTANE; (−)1-ISOTHIOCYANATO-4S-(METHYLSULFINYL)-BUTANE; (+)1-ISOTHIOCYANATO-4S-(METHYLSULFINYL)-BUTANE
Application:
D,L-Sulforaphane is a selective inducer of phase II detoxification enzymes used for breast cancer research
CAS Number:
4478-93-7
Purity:
≥90%
Molecular Weight:
177.29
Molecular Formula:
C6H11NOS2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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D,L-Sulforaphane (SFN) is a potent and selective inducer of phase II detoxification enzymes with anticarcinogenic and anti-microbial properties. D,L-Sulforaphane acts as an antitumor agent that was found to inhibit chemically induced mammary tumor formation in rats. D,L-Sulforaphane increases the transcription of tumor suppressor proteins and inhibits histone deacetylases. D,L-Sulforaphane is an inhibitor of Aryl Hydrocarbon Receptor. D,L-Sulforaphane regulates inflammatory responses by suppressing the LPS-mediated expression of iNOS, COX-2, IL-1β and TNF-α.


D,L-Sulforaphane (CAS 4478-93-7) References

  1. A major inducer of anticarcinogenic protective enzymes from broccoli: isolation and elucidation of structure.  |  Zhang, Y., et al. 1992. Proc Natl Acad Sci U S A. 89: 2399-403. PMID: 1549603
  2. D,L-Sulforaphane-induced cell death in human prostate cancer cells is regulated by inhibitor of apoptosis family proteins and Apaf-1.  |  Choi, S., et al. 2007. Carcinogenesis. 28: 151-62. PMID: 16920735
  3. Pretreatment of human epidermal keratinocytes with D,L-sulforaphane protects against sulfur mustard cytotoxicity.  |  Gross, CL., et al. 2006. Cutan Ocul Toxicol. 25: 155-63. PMID: 16980241
  4. Induction of p21 protein protects against sulforaphane-induced mitotic arrest in LNCaP human prostate cancer cell line.  |  Herman-Antosiewicz, A., et al. 2007. Mol Cancer Ther. 6: 1673-81. PMID: 17513615
  5. D,L-Sulforaphane causes transcriptional repression of androgen receptor in human prostate cancer cells.  |  Kim, SH. and Singh, SV. 2009. Mol Cancer Ther. 8: 1946-54. PMID: 19584240
  6. Sulforaphane suppresses LPS-induced inflammation in primary rat microglia.  |  Brandenburg, LO., et al. 2010. Inflamm Res. 59: 443-50. PMID: 19924513
  7. Sulforaphane inhibits constitutive and interleukin-6-induced activation of signal transducer and activator of transcription 3 in prostate cancer cells.  |  Hahm, ER. and Singh, SV. 2010. Cancer Prev Res (Phila). 3: 484-94. PMID: 20233902
  8. Separation and purification of sulforaphane from broccoli by solid phase extraction.  |  Han, D. and Row, KH. 2011. Int J Mol Sci. 12: 1854-61. PMID: 21673926
  9. D,L-sulforaphane-induced apoptosis in human breast cancer cells is regulated by the adapter protein p66Shc.  |  Sakao, K. and Singh, SV. 2012. J Cell Biochem. 113: 599-610. PMID: 21956685
  10. Ciliopathy proteins regulate paracrine signaling by modulating proteasomal degradation of mediators.  |  Liu, YP., et al. 2014. J Clin Invest. 124: 2059-70. PMID: 24691443
  11. D, L-Sulforaphane Loaded Fe3O4@ Gold Core Shell Nanoparticles: A Potential Sulforaphane Delivery System.  |  Kheiri Manjili, H., et al. 2016. PLoS One. 11: e0151344. PMID: 26982588
  12. Aldo-keto reductases are biomarkers of NRF2 activity and are co-ordinately overexpressed in non-small cell lung cancer.  |  MacLeod, AK., et al. 2016. Br J Cancer. 115: 1530-1539. PMID: 27824809
  13. d,l-Sulforaphane Induces ROS-Dependent Apoptosis in Human Gliomablastoma Cells by Inactivating STAT3 Signaling Pathway.  |  Miao, Z., et al. 2017. Int J Mol Sci. 18: PMID: 28054986
  14. Anticarcinogenic activities of sulforaphane and structurally related synthetic norbornyl isothiocyanates.  |  Zhang, Y., et al. 1994. Proc Natl Acad Sci U S A. 91: 3147-50. PMID: 8159717

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

D,L-Sulforaphane, 5 mg

sc-207495A
5 mg
$153.00

D,L-Sulforaphane, 10 mg

sc-207495B
10 mg
$292.00

D,L-Sulforaphane, 25 mg

sc-207495C
25 mg
$489.00

D,L-Sulforaphane, 250 mg

sc-207495D
250 mg
$933.00

D,L-Sulforaphane, 1 g

sc-207495
1 g
$1325.00

D,L-Sulforaphane, 10 g

sc-207495E
10 g
$8465.00

Hello’  I just want to ask about the volume in the container  Thank you 

Asked by: Loda
This chemical is a pure liquid sold in mass. Unfortunately volume is not characterized.
Answered by: Tech Sales
Date published: 2021-07-09

What size of packages does the product come in?

Asked by: bteye
Thank you for your question. Please contact Technical Support at 1800-457-3801 option 2, by emailing scbt@scbt.com or by live chat on our website at www.scbt.com so we may further assist you.
Answered by: Santa Cruz TS
Date published: 2021-07-07

What is the maximum absorbance wavelength of D,L Sulforaphane ??

Asked by: vinaynit21
Thank you for your question. We have not tested the maximum absorbance wavelength of D,L Sulforaphane. According to the below journal article, Sulforaphane displayed the largest absorbance under 205 nm. Han, D., Et al. 2011. Int. J. Mol .Sci. 12(3):.1854-1861.PMID: 21673926
Answered by: Technical Support
Date published: 2019-09-11

I was wondering what solvents can be used to dissolve this product?

Asked by: 13punMA
Thank you for asking about our D,L-Sulforaphane (CAS# 4478-93-7). The recommended solvents for the product is Chloroform, Dichloromethane, or Diethyl Ether.
Answered by: Chemical Support 8
Date published: 2017-03-10

I was wondering if there are any special instructions for storing the product to keep it stable for long periods.

Asked by: 13punMA
Thank you for asking about our D,L-Sulforaphane (CAS# 4478-93-7). For long term storage, the product should be dissolved in Chloroform, Dichloromethane or Diethyl Ether at -20 ºC. Otherwise the product would be best if made fresh.
Answered by: Chemical Support 8
Date published: 2017-03-10

Is the appearance of this compound, it's native form? If not, what is the liquid it is stored in?

Asked by: 13punMA
Hello, thank you for asking about our product D,L-Sulforaphane (CAS# 4478-93-7) The product comes in its pure form and is not dissolved in anything at all.
Answered by: Chemical Support 8
Date published: 2017-03-01
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Rated 5 out of 5 by from SF (5 M; 4 h) treatment was included asSF (5 M; 4 h) treatment was included as a positive control - published western blot data. -SCBT Publication Review
Date published: 2015-07-27
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D,L-Sulforaphane is rated 5.0 out of 5 by 1.
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