Molecular structure of RG 108, CAS Number: 48208-26-0
RG 108 (CAS 48208-26-0)
See product citations (2)
Alternate Names:
DNA Methyltransferase Inhibitor
Application:
RG 108 is a Dnmt inhibitor that silences tumor suppressor genes
CAS Number:
48208-26-0
Purity:
≥97%
Molecular Weight:
334.33
Molecular Formula:
C19H14N2O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
RG 108 is a non-nucleoside DNA methyltransferase (Dnmt) inhibitor that blocks the enzyme active site. RG 108 inhibits DNA methylation in human cancer cell lines without detectable toxicity in vitro. The compound demethylates and reactivates epigenetically silences tumor suppressor genes. RG 108 is a small molecule inhibitor that is used in the field of epigenetics and gene expression research. It specifically targets DNA methyltransferases (DNMTs), which are enzymes responsible for adding methyl groups to DNA molecules. By inhibiting DNMT activity, RG 108 can alter DNA methylation patterns and influence gene expression.
RG 108 (CAS 48208-26-0) References
- Sensitization by 5-azacytidine toward death receptor-induced hepatic apoptosis. | Weiland, T., et al. 2009. J Pharmacol Exp Ther. 328: 107-15. PMID: 18829727
- Epigenetic signatures in cancer: Implications for the control of cancer in the clinic. | Lima, SC., et al. 2010. Curr Opin Mol Ther. 12: 316-24. PMID: 20521220
- Tenuipyrone, a novel skeletal polyketide from the entomopathogenic fungus, Isaria tenuipes, cultivated in the presence of epigenetic modifiers. | Asai, T., et al. 2012. Org Lett. 14: 513-5. PMID: 22201477
- Treatment with small molecules is an important milestone towards the induction of pluripotency in neural stem cells derived from human cord blood. | Szablowska-Gadomska, I., et al. 2012. Acta Neurobiol Exp (Wars). 72: 337-50. PMID: 23377265
- Differential contributions of de novo and maintenance DNA methyltransferases to object memory processing in the rat hippocampus and perirhinal cortex--a double dissociation. | Mitchnick, KA., et al. 2015. Eur J Neurosci. 41: 773-86. PMID: 25639476
- Comparing The Effects of Small Molecules BIX-01294, Bay K8644, RG-108 and Valproic Acid, and Their Different Combinations on Induction of Pluripotency Marker-Genes by Oct4 in The Mouse Brain. | Asadi, S., et al. 2015. Cell J. 16: 416-25. PMID: 25685732
- Specific combinations of the chromatin-modifying enzyme modulators significantly attenuate glioblastoma cell proliferation and viability while exerting minimal effect on normal adult stem cells growth. | Alexanian, AR. and Huang, YW. 2015. Tumour Biol. 36: 9067-72. PMID: 26084611
- Pharmacokinetics of the Experimental Non-Nucleosidic DNA Methyl Transferase Inhibitor N-Phthalyl-L-Tryptophan (RG 108) in Rats. | Schneeberger, Y., et al. 2016. Basic Clin Pharmacol Toxicol. 118: 327-32. PMID: 26525153
- Activation of SIRT6 by DNA hypomethylating agents and clinical consequences on combination therapy in leukemia. | Carraway, HE., et al. 2020. Sci Rep. 10: 10325. PMID: 32587297
- Differentiation of mouse embryonic stem cells into cells with spermatogonia-like morphology with chemical intervention-dependent increased gene expression of LIM homeobox 1 (Lhx1). | Moshfegh, C., et al. 2022. Stem Cell Res. 61: 102780. PMID: 35395624
- Unique combinations of epigenetic modifiers synergistically impair the viability of the U87 glioblastoma cell line while exhibiting minor or moderate effects on normal stem cell growth. | Alexanian, AR. and Brannon, A. 2022. Med Oncol. 39: 86. PMID: 35478054
- Tissue-specific identification of multi-omics features for pan-cancer drug response prediction. | Zhao, Z., et al. 2022. iScience. 25: 104767. PMID: 35992090
- EnrichIntersect: an R package for custom set enrichment analysis and interactive visualization of intersecting sets. | Zhao, Z., et al. 2022. Bioinform Adv. 2: vbac073. PMID: 36699400
Inhibitor of:
β-defensin 127, 0610006L08Rik, 0610008F07Rik, 2310079F23Rik, 2610110G12Rik, 2810011L19Rik, 2810422O20Rik, 2810474O19Rik, 4832428D23Rik, 4921506J03Rik, 4930557A04Rik, 5-Methylcytidine, 7530422B04Rik, ADAM4, ADAMTS-L2, Akirin2, ALKBH2, ALS2CL, ANKRD11, ANKRD12, ANKRD20A5, ANKRD30B, ANKRD41, ANKRD60, ANKRD62, ANP32B, apoL11b, APRG1, ARD, ARID3C, Arp, ASB-13, ASCIZ, ASMTL, ASRGL1, ASXL1, Ataxin-8, B630005N14Rik, BAF60a, BAGE3, BAHD1, Basonuclin 2, BAT2L, BAT3, BAT4, BAZ1A, BBS6, BC010304, BC067068, BCDIN3, BCORL1, Bex4, Blood Group H2, BORIS, BTBD12, C10orf105, C12orf56, C12orf71, C14orf102, C14orf38, C1orf156, C1orf181, C1orf43, C3orf14, C5orf35, C6orf120, C9orf41, CBX6, CCDC116, CD92, CDYL2, CEM15, Chr-B, CMG1, Codanin-1, COL13A, CXorf34, DACH2, DCAMKL2, Dexras1, Dmap1, DNAH10, DNAH12, DNAS1L3, DNC, Dnmt, Dnmt1, Dnmt2, Dnmt3a, Dnmt3b, Dnmt3L, DPRX, DSC1A, DYDC2, Dynlt1d, EAP30, EF-CBP1, EFTA, EG385328, EG546205, Elongin A2, ESCO1, ESET, FAM165B, Fibrillarin-like 1, FLJ36157, FLJ42117, FOXD4L4, FTSJ1, FTSJ3, GAGE13, GATC, GCFC1, GFRα-1, gliacolin, Gm362, Gm428, Gm608, GMAP-210_TRIP11, GPR42, Grid2, GSE1, H2-M1, H2-M10.3, H2-M11, H2afb2, H2al2y, H3-K9-HMTase, Hbb-y, HCF2, hCG_1795065, Helios, HEMK2, HEN1, Hils1, HIRA, Histone cluster 1 H1A, Histone cluster 1 H1D, Histone cluster 1 H1T, Histone cluster 1 H2AO, Histone cluster 1 H3E, Histone cluster 1 H4F, Histone cluster 1 H4K, Histone cluster 1 H4M, Histone cluster 3 H3, Histone H1X, Histone H2A.F, Histone H2A.J, Histone H3.3A, Histone H3F3C, HIV-1 Tat-SF1, HMG-B3, HNF-6, HoxA2, HoxA4, HoxA7, HoxD4, HP1β, HP1BP3, HSMNP1, HSPC038, IFITM1, IINTS1, Inhibin β-C, Integrin αIIIb, IRF-2BP2, IRX3, JK-1, JMJD1A, JRK, K230010J24Rik, KCNMB4, Khdc1a, KIAA1429, KIAA1462, KLRF1, KRTAP1, KRTAP12-4, KRTAP16-4, KRTAP19-3, KRTAP19-7, KRTAP21-1, KRTAP21-2, KRTAP26-1, KRTAP8-2, Lce1a1, Lce1i, LEMD2, LGALS9C, LHX8, Lipocalin-11, LOC100039763, LOC100039799, LOC100040208, LOC100040458, LOC100040491, LOC100040657, LOC100040781, LOC100040962, LOC100041004, LOC100041179, LOC145783, LOC283143, LOC339674, LOC340094, LOC401397, LOC439994, LOC440900, LOC642426, LOC644248, LOC644838, LOC646324, LOC646719, LOC646817, LOC728109, LOC728957, LOC729458, LOC85449, LSAMP, LSm3, Lyl-1, MACF1-4, MacroH2A2, Mael, MAGE-A6, MAGE-E1, MAGE-E2, MAGE-G2, MAP-2A, MAP-2B, MBD3L2, MBD3L3, MBD3L4, MBD3L5, MBD6, MCART1, MCFD2L, Mesogenin 1, METT10D, METT11D1, METTL12, METTL2, METTL22, METTL23, METTL25, METTL2A, METTL2B, Mettl7a2-Higd1c, METTL9, MGAT3, MGC50559_4833442J19Rik, MILI, Morc1, Morc3, MORF4L2, MPDZ, MRG1, MRGBP, MRGX4, MSL3L1, MYBPC3, MYL5, NAP5, NAT-9, NBPF8, netrin G2, Neurexophilin-3, Neuroglycan C, NIF-1, NPSF, NRDE-2, NSUN1, NSUN2, NSUN3, NSUN5, NSUN5B, NSUN5C, NSUN6, NSUN7, NY-REN-34, Obox5, OC-2, Oct-3A, OR1M1, OR52E8, OR52I2, OR52L1, OR5AS1, OR7C1, OTTMUSG00000016784, p400, P42pop, Paired Box (PAX), Pax-6, PAX9, PCDH10_Pcdh10, PCDH11Y, PCDHA1, PCDHA12, PCDHA2, PCDHA3, PCDHAC2_Pcdhac2, Pcdhb22, PCDHGA1, PCDHGA12, PCDHGA5, PCDHGA6, PCDHGA9, PCDHGB3, PCDHGB5, PCMT1, PCMTD1, Peg10, PGs2_5730494M16Rik, PHF13, PHF20, PHF20L1, PHF21B, PIG-T, PIWIL4, PLAGL1, Pneumadin, POU6F2, PRAMEF14, PRAMEF18, PRAMEF2, PRAMEF23, PRAMEF25, PRAMEF9, PRDM10, PRDM15, PRDM3, PRDM8, PRDM9, PREP-1, PRHOXNB, Prickle2, Protamine 3, PRR20A, PRR20C, PRR20D, PRR20E, PRSS55, PSD3, PSKH2, PWWP2A, PWWP2B, RACK7, RASSF1A, RASSF1F, RBAK, RBM11, RBM35B, RBM42, RCOR2, Reg lllα, RFX2, RG9MTD1, RG9MTD3, RGS7 (regulator of G protein signaling), Rho GAP, Rho GAP p190B, Rhox2e, Rhox2g, Rhox2h, RNMT, RNMTL1, Rsl2, Rslcan-10, Rslcan-13, Rslcan-14, Rslcan-2, Rslcan-23, Rslcan-5, Rslcan-6, Rslcan-7, SAF-B, SAPAP3, SCA11, SCML2, SEEK1, SETD2, SETD4, SETD5, Siglec-5, SIM2, SIRP-α3, Six6os1, SMCHD1, SMYD1, SNURF, SorCS3, Sp9, SPIN2, SPNS2, SPOPL, SPR-5, SRRM5, SSX2-IP, SSX9, STELLA, STOX2, SUZ12, Synovial sarcoma X (SSX) breakpoint protein, TAF7L, TBC1D24, TBX15, TCEA2, TDG, TDRD1, TDRD10, TDRKH, TET1, TET3, TFPT, TGIF2LY, TIF1β, TIGD2, TIGD3, TIGD4, TIS11D, TM6SF2, TMC4, TMEM108, TMEM145, TMEM20, TMEM5, TNRC18, Tomt, TOX3, TRIM5α, TRM61, TRMU, TSPAN6, TSPY8, TSPYL4, TSSC3, UHRF1, UNC5C, USP49, Vangl2, VpreB3, VSTM2A, VSX1, WDR38, XAP8, XPLAC, YT521-B, YTHDC2, YTHDF2, ZBTB38, ZBTB43, ZC3H7A, ZCCHC17, ZCCHC6, ZCWCC1, ZCWPW1, ZCWPW2, ZDBF2, ZFP383, ZFP39, ZFP40, ZFP433, ZFP57, ZFP59, ZFP605, ZFP61, ZFP712, ZFP719, Zfp78, ZFP811, ZFP819, ZFP839, Zfp93, Zfp931, ZFP936, ZFP963, ZFP97, ZFY1, ZFY2, ZIM3, ZKSCAN4, ZMYM3, ZNF136, ZNF160, ZNF165, ZNF174, ZNF19, ZNF197, ZNF198, ZNF206, ZNF222, ZNF224, ZNF232, ZNF237, ZNF250, ZNF251, ZNF263, ZNF267, ZNF268, ZNF279, ZNF295, ZNF3, ZNF304, ZNF322A, ZNF323, ZNF334, ZNF337, ZNF34, ZNF341, ZNF343, ZNF35, ZNF385A, ZNF434, ZNF442, ZNF445, ZNF446, ZNF469, ZNF499, ZNF500, ZNF502, ZNF508, ZNF518B, ZNF519, ZNF532, ZNF533, ZNF536, ZNF541, ZNF544, ZNF563, ZNF572, ZNF576, ZNF596, ZNF607, ZNF619, ZNF621, ZNF623, ZNF625, ZNF641, ZNF644, ZNF672, ZNF678, ZNF711, ZNF740, ZNF76, ZNF780B, ZNF785, ZNF800, ZNF808, ZNF81, ZNF836, ZNF84, ZNF841, ZNF844, ZNF853, ZNF862, and ZNHIT1.Activator of:
β1-Syntrophin, 7530422B04Rik, ALKBH5, ARID3B, ASH2L, ASXL2, ASXL3, BC006662, Bdf1, BRD9, BRMS1L, BRUNOL4, BRWD1, BTBD14A, BTF3, C1orf69, C3orf30, C3orf33, CAF-1 p150, CCDC21, CDYL, CGBP, CLAMP, CSS2, Cux2, DAZAP1, DDA3, Dimethyl Histone H3, DPF1, DPPA4, DZIP3, E(z), EAF1, EBLN2, ECOP, EG210583, EG210853, EG236663, EG385328, EHMT1, EMID2, ERI-1, EZHIP, FAM208A, FBXO8, FMR2, FRG2C, GAGE13, Glrp-1, GOLGA8B, H2-M9, H2afb2, H2BFWT, Histone cluster 1 H2AD, Histone cluster 1 H2AL, Histone cluster 1 H2BA, Histone cluster 1 H2BD, Histone cluster 1 H2BE, Histone cluster 1 H2BJ, Histone cluster 1 H2BL, Histone cluster 1 H3B, Histone cluster 1 H3C, Histone cluster 1 H3G, Histone cluster 1 H4H, Histone cluster 2 H2BE, Histone cluster 2 H3A, Histone cluster 2 H4A, Histone cluster 3 H2BB, Histone H2A.Z, Histone H2B.S, Histone H2BM, Histone H3.3B, HKDC1, HMG I, HMG-1L, HMG-4, hnRNP E3, HP1γ, HSZFP36, HTR3E, INTS4, JMJD4, Khdc1b, kismet, KRBOX1, L3MBTL, LIN-53, LOC100041215, LOC100041231, LOC340094, LOC439950, LOC441461, LOC643749, LOC644248, LOC646719, LOC729454, MAGE-G2, MBD1, MBD3L2, MBD3L2-5, MBD3L3, MBD3L4, MBD6, Med12l, Med22, METTL14, METTL4, MIER2, MLL3, MLLT6, Morc1, MOV10L1, MRGBP, MTF-2, MYSM1, N6AMT2, Nanog, NAP1L1, NAP1L2, NAP1L5, NBPF3, NESP55, NXF3, OR6K3, PC4, PCGF6, Peg12, PHC1, PHF12, PHF8, PLEKHA6, POLR2B, PRAMEF17, PRDM11, PRDM14, PRDM5, PRR14, PRR19, PWWP2B, RALYL, RBBP1, RBMXL1, RGD1564058, Rhox10, Rhox11, Rhox12, Rhox13, RNase HII-B, RSRC1, SAP 130, SAP 30, SCAND1, SCML1, SETD6, SETMAR, SFMBT1, SGS3, Snf5, SNURF, Sox-22, SPEN, SS18L2, Staf-50, SUV420H2, Swi1, TADA2L, TAF II p135, TAF II p28, TBL1Y, TBX5, TCEA3, TDRD5, THAP10, TIGD5, TNRC6B, TSPYL6, U11/U12 snRNP 25, u4/u6 snRNP, UBN-2, UTY, VPS72, WIZ, ZBBX_FLJ23049, ZC3H13, ZCWPW1, ZFP1, ZFP287, ZFR2, ZFYVE28, ZKSCAN1, ZMYND12, ZNF142, ZNF21, ZNF213, ZNF222, ZNF236, ZNF275, ZNF336, ZNF345, ZNF385A, ZNF396, ZNF408, ZNF449, ZNF452, ZNF500, ZNF575, ZNF579, ZNF583, ZNF620, ZNF646, ZNF709, ZNF75A, ZNF778, ZNF780B, and ZSWIM6.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
RG 108, 10 mg | sc-204235 | 10 mg | $128.00 | |||
RG 108, 50 mg | sc-204235A | 50 mg | $505.00 |