Disulfiram is a DNA demethylating agent and DIG1 inducer which inhibits prostate cancer cell growth by inhibition of DNA methyltransferase (Dnmt). In addition, studies indicate that disulfiram inhibits aldehyde dehydrogenase (ALDH) resulting in the accumulation of acetaldehyde upon ethanol ingestion. Alternate studies show that disulfiram also inhibits dopamine β-hydroxylase (DBH), an enzyme important in converting dopamine to norepinephrine in noradrenergic neurons. Futhermore, disulfiram can reduce toxicity and carcinogenesis by inhibiting the cytochrome P450IIE1 (CYP2E1). It has been reported that disulfiram can also inhibit tumor cell growth via binding to cellular copper, which inhibits proteosome activity and induces apoptosis. Disulfiram is an inhibitor of ADH and V-ATPase.
1. Brady, J.F., et al. 1991. Toxicol. Appl. Pharmacol. 108: 366-373. PMID: 1850173 2. Schroeder, J.P., et al. 2010. Neuropsychopharmacology. 35: 2440-2449. PMID: 20736996 3. Lin, J., et al. 2010. Prostate. [Epub ahead of print]. PMID: 20809552 4. Wang, F., et al. 2011. Cancer Lett. 300: 87-95. PMID: 21035945
Soluble in water (4 mg/l at 25° C), acohol (38.2 mg/ml), ether (71.4 mg/ml), chloroform, and acetonitrile.
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Wang et alWang et al. (PubMed ID 21035945) used disulfiram to inhibit aldehyde dehydrogenase and found that this inactivated proteasome activity and induced cancer cell apoptosis. -SCBT Publication Review
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