Date published: 2025-11-24

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Disulfiram (CAS 97-77-8)

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Alternate Names:
Tetraethylthiuram disulfide
Application:
Disulfiram is an ALDH and tumor cell growth inhibitor
CAS Number:
97-77-8
Purity:
≥97%
Molecular Weight:
296.54
Molecular Formula:
C10H20N2S4
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Disulfiram is a DNA demethylating agent and DIG1 inducer which inhibits prostate cancer cell growth by inhibition of DNA methyltransferase (Dnmt). In addition, studies indicate that disulfiram inhibits aldehyde dehydrogenase (ALDH) resulting in the accumulation of acetaldehyde upon ethanol ingestion. Alternate studies show that disulfiram also inhibits dopamine beta-hydroxylase (DBH), an enzyme important in converting dopamine to norepinephrine in noradrenergic neurons. Futhermore, disulfiram can reduce toxicity and carcinogenesis by inhibiting the cytochrome P450IIE1 (CYP2E1). It has been reported that disulfiram can also inhibit tumor cell growth via binding to cellular copper, which inhibits proteosome activity and induces apoptosis. Disulfiram is an inhibitor of ADH and V-ATPase.


Disulfiram (CAS 97-77-8) References

  1. Effects of disulfiram on hepatic P450IIE1, other microsomal enzymes, and hepatotoxicity in rats.  |  Brady, JF., et al. 1991. Toxicol Appl Pharmacol. 108: 366-73. PMID: 1850173
  2. Disulfiram attenuates drug-primed reinstatement of cocaine seeking via inhibition of dopamine β-hydroxylase.  |  Schroeder, JP., et al. 2010. Neuropsychopharmacology. 35: 2440-9. PMID: 20736996
  3. Disulfiram is a DNA demethylating agent and inhibits prostate cancer cell growth.  |  Lin, J., et al. 2011. Prostate. 71: 333-43. PMID: 20809552
  4. A novel dithiocarbamate analogue with potentially decreased ALDH inhibition has copper-dependent proteasome-inhibitory and apoptosis-inducing activity in human breast cancer cells.  |  Wang, F., et al. 2011. Cancer Lett. 300: 87-95. PMID: 21035945
  5. Alcohol-abuse drug disulfiram targets cancer via p97 segregase adaptor NPL4.  |  Skrott, Z., et al. 2017. Nature. 552: 194-199. PMID: 29211715
  6. Therapeutic effect of disulfiram inclusion complex embedded in hydroxypropyl-β-cyclodextrin on intracranial glioma-bearing male rats via intranasal route.  |  Qu, Y., et al. 2021. Eur J Pharm Sci. 156: 105590. PMID: 33065226
  7. Disulfiram inhibits inflammation and fibrosis in a rat unilateral ureteral obstruction model by inhibiting gasdermin D cleavage and pyroptosis.  |  Zhang, Y., et al. 2021. Inflamm Res. 70: 543-552. PMID: 33851234
  8. Glutathione-responsive copper-disulfiram nanoparticles for enhanced tumor chemotherapy.  |  Chen, M., et al. 2022. J Control Release. 341: 351-363. PMID: 34856225
  9. Repurposing Disulfiram as a Chemo-Therapeutic Sensitizer: Molecular Targets and Mechanisms.  |  Sun, F., et al. 2022. Anticancer Agents Med Chem. 22: 2920-2926. PMID: 35430981
  10. Disulfiram bolsters T-cell anti-tumor immunity through direct activation of LCK-mediated TCR signaling.  |  Wang, Q., et al. 2022. EMBO J. 41: e110636. PMID: 35638332
  11. Buffet-style Cu(II) for enhance disulfiram-based cancer therapy.  |  Zhao, L., et al. 2022. J Colloid Interface Sci. 624: 734-746. PMID: 35696791
  12. Disulfiram's journey from rubber vulcanization to T-cell activation.  |  Dosset, M. and Zanetti, M. 2022. EMBO J. 41: e111862. PMID: 35848116
  13. Disulfiram and dithiocarbamate analogues demonstrate promising antischistosomal effects.  |  Rennar, GA., et al. 2022. Eur J Med Chem. 242: 114641. PMID: 36027862
  14. Disulfiram loaded calcium phosphate nanoparticles for enhanced cancer immunotherapy.  |  Li, Q., et al. 2022. Biomaterials. 291: 121880. PMID: 36334355
  15. Disulfiram accelerates diabetic foot ulcer healing by blocking NET formation via suppressing the NLRP3/Caspase-1/GSDMD pathway.  |  Yang, S., et al. 2023. Transl Res. 254: 115-127. PMID: 36336332

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Disulfiram, 50 g

sc-205654
50 g
$52.00

Disulfiram, 100 g

sc-205654A
100 g
$87.00