Fam148b Activators
Chemical activators of C2 calcium dependent domain containing 4B (C2CD4B) encompass a variety of compounds that influence intracellular calcium levels, a key regulator for the activation of this protein. Calcium chloride directly contributes to the activation of C2CD4B by increasing the concentration of calcium ions within the cell. Similarly, ionophores like ionmycin and calcimycin facilitate the influx of calcium ions into the cytosol from the extracellular space or intracellular stores, thereby providing the necessary calcium ions to activate C2CD4B. Thapsigargin serves this role by a different mechanism; it inhibits the sarcoplasmic/endoplasmic reticulum Ca2+ ATPase (SERCA), leading to a buildup of cytosolic calcium that, in turn, activates C2CD4B.
Furthermore, compounds that modulate calcium channels or signaling pathways indirectly influence the activation state of C2CD4B. Phorbol 12-myristate 13-acetate (PMA) and 1,2-Dioctanoyl-sn-glycerol (DiC8) activate protein kinase C (PKC), which is known to enhance downstream calcium-dependent processes, including those involving C2CD4B. BAY K 8644 and its more specific enantiomer, (S)-(-)-Bay K 8644, act as L-type calcium channel agonists, boosting calcium entry into the cell, which aids in the activation of C2CD4B. Nitrendipine, by blocking these channels, paradoxically can also lead to increased intracellular calcium that activates C2CD4B. Another modulator, FPL 64176, enhances calcium influx through its action on calcium channels, thereby promoting C2CD4B activation. Lastly, cyclopiazonic acid and ryanodine disrupt calcium regulation within the cell by inhibiting the SERCA pump and modifying ryanodine receptor function, respectively; both result in elevated cytosolic calcium levels that facilitate C2CD4B activation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Calcium chloride anhydrous | 10043-52-4 | sc-207392 sc-207392A | 100 g 500 g | $66.00 $262.00 | 1 | |
Calcium chloride can activate C2 calcium dependent domain containing 4B (C2CD4B) by increasing intracellular calcium levels, which is essential for the function of calcium-dependent proteins. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Thapsigargin raises cytosolic calcium by inhibiting the sarcoplasmic/endoplasmic reticulum Ca2+ ATPase (SERCA), which can lead to the activation of C2CD4B as it depends on calcium for its activity. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Ionmycin is a calcium ionophore that increases intracellular calcium concentration, which can directly activate C2CD4B by providing the necessary calcium ions for its activation. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
Calcimycin, also known as A23187, is another calcium ionophore that can elevate intracellular calcium and thereby activate C2CD4B. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA activates protein kinase C (PKC) which can lead to the activation of downstream proteins that require calcium binding for activation, including C2CD4B. | ||||||
1,2-Dioctanoyl-sn-glycerol | 60514-48-9 | sc-202397 sc-202397A | 10 mg 50 mg | $47.00 $254.00 | 2 | |
DiC8 acts as a synthetic diacylglycerol (DAG) analog which activates PKC, and PKC activation can in turn activate C2CD4B by enhancing calcium-dependent processes. | ||||||
(±)-Bay K 8644 | 71145-03-4 | sc-203324 sc-203324A sc-203324B | 1 mg 5 mg 50 mg | $84.00 $196.00 $817.00 | ||
BAY K 8644 acts as a L-type calcium channel agonist which can increase intracellular calcium and subsequently activate C2CD4B, as it is calcium-dependent. | ||||||
Nitrendipine | 39562-70-4 | sc-201466 sc-201466A sc-201466B | 50 mg 100 mg 500 mg | $109.00 $160.00 $458.00 | 6 | |
Nitrendipine, by blocking L-type calcium channels, can cause a compensatory increase in intracellular calcium which may activate C2CD4B through calcium-dependent mechanisms. | ||||||
FPL-64176 | 120934-96-5 | sc-201491 | 5 mg | $83.00 | 1 | |
FPL 64176 is a calcium channel modulator that can increase calcium influx, thereby activating C2CD4B by providing the calcium ions required for its activity. | ||||||
Cyclopiazonic Acid | 18172-33-3 | sc-201510 sc-201510A | 10 mg 50 mg | $176.00 $624.00 | 3 | |
Cyclopiazonic Acid inhibits the SERCA pump leading to an increase in cytosolic calcium, which can activate C2CD4B by enhancing its calcium-dependent activation. | ||||||