Date published: 2025-9-30

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A23187 (CAS 52665-69-7)

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Alternate Names:
Calimycin;Antibiotic A-23187
Application:
A23187 is a highly selective Ca2+ ionophore
CAS Number:
52665-69-7
Purity:
≥97%
Molecular Weight:
523.62
Molecular Formula:
C29H37N3O6
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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A23187 is an ionophore, highly selective for Ca2+, that allows for divalent cations to move across the membranes which are usually impermeable to them. The compound was originally isolated from Streptomyces chartreusensis for use as an antibiotic but may act to have weak in vitro antimicrobial activity against fungi and gram positive bacteria. Because of its ability to increase intracellular calcium levels of intact cells, it is used in studies of intracellular Ca2+ mediated events. A23187 has been observed to induce cell activation, differentiation or proliferation. In vitro experimentation has shown A23187 to boost ROS generation and platelet fragmentation.


A23187 (CAS 52665-69-7) References

  1. Calcium ionophore A23187 action on cardiac myocytes is accompanied by enhanced production of reactive oxygen species.  |  Przygodzki, T., et al. 2005. Biochim Biophys Acta. 1740: 481-8. PMID: 15949718
  2. Combination of calcium ionophore A23187 with puromycin salvages human unfertilized oocytes after ICSI.  |  Lu, Q., et al. 2006. Eur J Obstet Gynecol Reprod Biol. 126: 72-6. PMID: 16352389
  3. Platelet particle formation by anti GPIIIa49-66 Ab, Ca2+ ionophore A23187, and phorbol myristate acetate is induced by reactive oxygen species and inhibited by dexamethasone blockade of platelet phospholipase A2, 12-lipoxygenase, and NADPH oxidase.  |  Nardi, MA., et al. 2007. Blood. 110: 1989-96. PMID: 17545506
  4. Mechanism of A23187-induced apoptosis in HL-60 cells: dependency on mitochondrial permeability transition but not on NADPH oxidase.  |  Kajitani, N., et al. 2007. Biosci Biotechnol Biochem. 71: 2701-11. PMID: 17986779
  5. Effect of the ionophore A23187 on chloride transport across isolated frog cornea.  |  Candia, OA., et al. 1977. Am J Physiol. 233: F94-101. PMID: 329688
  6. Calcium Ionophore (A23187) Rescues the Activation of Unfertilized Oocytes After Intracytoplasmic Sperm Injection and Chromosome Analysis of Blastocyst After Activation.  |  Xu, Z., et al. 2021. Front Endocrinol (Lausanne). 12: 692082. PMID: 34335469
  7. Extracellular vesicles from A23187-treated neutrophils cause cGAS-STING-dependent IL-6 production by macrophages.  |  Allen, ER., et al. 2022. Front Immunol. 13: 949451. PMID: 35967325
  8. Calcium ionophore A23187 induces interleukin 2 reactivity in human T cells.  |  Clevers, HC., et al. 1985. Scand J Immunol. 22: 633-8. PMID: 3937226
  9. The diaphragm as a muscle. Mechanisms underlying fatigue.  |  Edwards, RH. 1979. Am Rev Respir Dis. 119: 81-4. PMID: 426361
  10. Effects of antibiotic ionophore, A23187, on oxidative phosphorylation and calcium transport of liver mitochondria.  |  Wong, DT., et al. 1973. Arch Biochem Biophys. 156: 578-85. PMID: 4268878
  11. A model for the regulation of the calmodulin-dependent enzymes erythrocyte Ca2+-transport ATPase and brain phosphodiesterase by activators and inhibitors.  |  Gietzen, K., et al. 1982. Biochem J. 207: 541-8. PMID: 6299272
  12. Calcimycin-induced lens epithelial cell apoptosis contributes to cataract formation.  |  Li, WC., et al. 1995. Exp Eye Res. 61: 91-8. PMID: 7556474
  13. The effect of A23187 ionophore on calcium movements and contraction processes in single barnacle muscle fibres.  |  Desmedt, JE. and Hainaut, K. 1976. J Physiol. 257: 87-107. PMID: 781214
  14. A23187 releases bound rather than free calcium from calcium-loaded liposomes.  |  Clack, JW., et al. 1994. Biochem Biophys Res Commun. 204: 142-9. PMID: 7945352

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

A23187, 1 mg

sc-3591
1 mg
$54.00

A23187, 5 mg

sc-3591B
5 mg
$128.00

A23187, 10 mg

sc-3591A
10 mg
$199.00

A23187, 25 mg

sc-3591C
25 mg
$311.00