Cyclopiazonic Acid CAS: 18172-33-3
MF: C20H20N2O3
MW: 336.4
An inhibitor of endoplasmic reticulum Ca2+-ATPase.

Cyclopiazonic Acid (CAS 18172-33-3)

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Alternate Names: CPA
Application: Cyclopiazonic Acid is an inhibitor of endoplasmic reticulum Ca2+-ATPase
CAS Number: 18172-33-3
Purity: ≥98%
Molecular Weight: 336.4
Molecular Formula: C20H20N2O3
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

Cyclopiazonic acid is an inhibiter of SERCA (endoplasmic reticulum Ca2+-ATPase) which induces the release of intracellular stored Ca2+, without increasing IP3 levels. It is a highly specific inhibitor of the SERCA(Ca2+-ATPase of sarcoplasmic reticulum), completely inhibiting the enzyme at 6-8 nmol/mg protein at the low concentration of 0.5-2 μM. The use of Cyclopiazonic acid on Langendorff-perfused murine hearts displayed anti-arrhythmic effects. Also, administration of cyclopiazonic acid on rat soleus muscle showed a decrease in hormone sensitive lipase activity and triacylglycerol hydrolysis.


References

1. Seidler, N.W., et al. 1989. J. Biol. Chem. 264: 17816-17823. PMID: 2530215
2. Bourreau, J.P., et al. 1991. Am. J. Physiol. 261: C497-C505. PMID: 1716053
3. Mason, M.J., et al. 1991. J. Biol. Chem. 266: 20856-20862. PMID: 1834651
4. Kurebayashi, N, et al. 1991. J. Muscle Res. Cell. Motil. 12: 355-365. PMID: 1834695
5. Uyama, Y., et al. 1992. Br. J. Pharmacol. 106: 208-214. PMID: 1387024
6. Demaurex, N., et al. 1992. J. Biol. Chem. 267: 2318-2324. PMID: 1531138
7. Abe, F., et al. 1996. Br. J. Pharmacol. 118: 1711-1716. PMID: 8842436
8. Watt, M.J., et al. 2003. Am. J. Physiol. Endocrinol. Metab. 285: E412-E419. PMID: 12759219
9. Martínez-Azorín, F., et al. 2004. FEBS Lett. 576: 73-76. PMID: 15474013b
10. Divet, A., et al. 2005. Acta Physiol. Scand. 184: 173-186. PMID: 15954985
11. Ghais, N.S., et al. 2008. Prog. Biophys. Mol. Biol. 98: 281-288. PMID: 19351518

Physical State :
Solid
Derived From :
Penicillium griseofulvum
Solubility :
Soluble in DMSO (100 mM), ethanol (5 mM), DMF (~20 mg/ml), and 1:1 DMSO:PBS(pH 7.2) (0.5 mg/ml). Insoluble in water.
Storage :
Store at -20° C
IC50 :
Sarco-endoplasmic reticulum Ca2+-ATPases: IC50 = 0.6 µM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
UY8587000
PubChem CID :
54675761
MDL Number :
MFCD00167445
SMILES :
CC(=O)C1=C(C2C3C(CC4=C5C3=CNC5=CC=C4)C(N2C1=O)(C)C)O

Download SDS (MSDS)

Certificate of Analysis

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Cyclopiazonic Acid (CAS 18172-33-3)  Product Citations

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Citations 1 to 1 of 1 total

PMID: # 28036359  Estep, CM. et al. 2016. PLoS ONE. 11: e0169044.

Citations 1 to 1 of 1 total
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Date published: 2015-04-20
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