Molecular structure of Cyclopiazonic Acid, CAS Number: 18172-33-3
Cyclopiazonic Acid (CAS 18172-33-3)
See product citations (3)
Alternate Names:
CPA
Application:
Cyclopiazonic Acid is an inhibitor of endoplasmic reticulum Ca2+-ATPase
CAS Number:
18172-33-3
Purity:
≥98%
Molecular Weight:
336.4
Molecular Formula:
C20H20N2O3
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Cyclopiazonic acid is an inhibiter of SERCA (endoplasmic reticulum Ca2+-ATPase) which induces the release of intracellular stored Ca2+, without increasing IP3 levels. It is a highly specific inhibitor of the SERCA(Ca2+-ATPase of sarcoplasmic reticulum), completely inhibiting the enzyme at 6-8 nmol/mg protein at the low concentration of 0.5-2 muM. The use of Cyclopiazonic acid on Langendorff-perfused murine hearts displayed anti-arrhythmic effects. Also, administration of cyclopiazonic acid on rat soleus muscle showed a decrease in hormone sensitive lipase activity and triacylglycerol hydrolysis.
Cyclopiazonic Acid (CAS 18172-33-3) References
- Hormone-sensitive lipase activity and triacylglycerol hydrolysis are decreased in rat soleus muscle by cyclopiazonic acid. | Watt, MJ., et al. 2003. Am J Physiol Endocrinol Metab. 285: E412-9. PMID: 12759219
- Effects of cyclopiazonic acid, a novel Ca(2+)-ATPase inhibitor, on contractile responses in skinned ileal smooth muscle. | Uyama, Y., et al. 1992. Br J Pharmacol. 106: 208-14. PMID: 1387024
- Cyclopiazonic acid depletes intracellular Ca2+ stores and activates an influx pathway for divalent cations in HL-60 cells. | Demaurex, N., et al. 1992. J Biol Chem. 267: 2318-24. PMID: 1531138
- Cyclopiazonic acid reduces the coupling factor of the Ca2+-ATPase acting on Ca2+ binding. | Martínez-Azorín, F. 2004. FEBS Lett. 576: 73-6. PMID: 15474013
- Effect of cyclopiazonic acid, an inhibitor of the sarcoplasmic reticulum Ca-ATPase, on skeletal muscles from normal and mdx mice. | Divet, A., et al. 2005. Acta Physiol Scand. 184: 173-86. PMID: 15954985
- Acetylcholine Ca2+ stores refilling directly involves a dihydropyridine-sensitive channel in dog trachea. | Bourreau, JP., et al. 1991. Am J Physiol. 261: C497-505. PMID: 1716053
- Coupling between intracellular Ca2+ stores and the Ca2+ permeability of the plasma membrane. Comparison of the effects of thapsigargin, 2,5-di-(tert-butyl)-1,4-hydroquinone, and cyclopiazonic acid in rat thymic lymphocytes. | Mason, MJ., et al. 1991. J Biol Chem. 266: 20856-62. PMID: 1834651
- Discrimination of Ca(2+)-ATPase activity of the sarcoplasmic reticulum from actomyosin-type ATPase activity of myofibrils in skinned mammalian skeletal muscle fibres: distinct effects of cyclopiazonic acid on the two ATPase activities. | Kurebayashi, N. and Ogawa, Y. 1991. J Muscle Res Cell Motil. 12: 355-65. PMID: 1834695
- Anti-arrhythmic effects of cyclopiazonic acid in Langendorff-perfused murine hearts. | Ghais, NS., et al. 2008. Prog Biophys Mol Biol. 98: 281-8. PMID: 19351518
- Cyclopiazonic acid is a specific inhibitor of the Ca2+-ATPase of sarcoplasmic reticulum. | Seidler, NW., et al. 1989. J Biol Chem. 264: 17816-23. PMID: 2530215
- Cyclopiazonic acid gene expression as strategy to minimizing mycotoxin contamination in cheese. | Casquete, R., et al. 2021. Fungal Biol. 125: 160-165. PMID: 33518206
- Coexposure of Cyclopiazonic Acid with Aflatoxin B1 Involved in Disrupting Amino Acid Metabolism and Redox Homeostasis Causing Synergistic Toxic Effects in Hepatocyte Spheroids. | Ma, X., et al. 2022. J Agric Food Chem. 70: 5166-5176. PMID: 35427130
- Cyclopiazonic Acid and Okaramine Analogues, Including Chlorinated Compounds, from Chrysosporium undulatum YT-1. | Liu, L., et al. 2022. J Nat Prod. 85: 2547-2556. PMID: 36268672
- Effects of cyclopiazonic acid and ryanodine on cytosolic calcium and contraction in vascular smooth muscle. | Abe, F., et al. 1996. Br J Pharmacol. 118: 1711-6. PMID: 8842436
Inhibitor of:
β′-COP, 4930408G06Rik, 5730419I09Rik, 9030025P20Rik, 9130409J20Rik, AHCYL2, ATP11A, ATP8B (P-type ATPases), ATP8B1, ATP8B5, ATPase, BAP29, BM88, BNIP-1, C17orf57, C19orf63, C2CD4D, CAB39L, CaBP7, Calmegin, Calumenin, CCDC47, CHERP, CLN6, CPN reg, CSTL1, CUTA, E6BP, EMC (ER Membrane Protein Complex), Ero1-Lα, Expansin, FAM158A, FAM69A, H2-Q8, HRC, IGLON5, ITPRIPL2, Junctophilin-4, KDEL receptor, KDEL receptor 1, KIAA0090, Mg29, MGC29506, MUP21, MUP7, Neurensin-1, Nmi, nucleobindin, PIG-L, PLAC8L1, Pma1, PMCA4, PMCA4b, PNMA6E, Rab 13, RBJ, RECS1, Reg II, Reticulum Cell, Ribophorin I, S-100P, scotin, SDF-2L1, SDF-4, Sec31A, Sec62, Sec63, SERCA, SERCA1, SERCA2, SERCA3, Shank 1, SPCA1, SPCA2, SPCS2, SWI5, taperin, TMCO4, TMCO5, TMEM165, TMEM203, TMEM38A, TMEM99, TMTC2, TMTC4, TMX3, Torsin4A, TRAM, Troponin T-SS, TRS85, V1RG4, V1RG5, V1RG6, V1RH2, V1RH4, Vmn2r16, and Vmn2r71.Activator of:
4931407G18Rik, ALG2, Apoptosis Repressor with CARD (ARC), ATF-6β, ATP13A1, ATP13A5, ATP8A2, BAT5, BTN2A1, C17orf57, C2CD4D, CaBP2, CAL, CALHM2, CALM, CALML5, calmodulin, calsequestrin 2, CANT1, CAPSL, CaT1, CAX1, CBARA1, CCDC109B, CLRN2, copine 7, copine 9, cryptdin 5, cryptdin 6, Derlin-1, EF-CAB2, EF-CAB7, EF-CAB8, EF-HB, ELKS, EOGT_A130022J15Rik, ERp27, Fam148b, GAAP, Grancalcin, HDEL, HSPA14, IPMK, ITPK1, ITPRIPL1, JAGN1, Jaw1, Junctional SR Marker, Junctophilin-3, KCMF1, KCNMB3, KDEL receptor 3, KIAA0494, KRTAP9, LOC285423, Lunapark, MBLAC1, MLEC, Nociceptin, nucleobindin 2, Olr232, Olr235, Olr24, Olr245, Olr251, Opalin, Orai3, PAFAH1B2, PEF, Pfpl, PMCA2, PMR1, Recoverin, reticulocalbin-1, reticulocalbin-2, reticulocalbin-3, RNF170, RRBP1, S-100Z, Sec61α2, SHISA6, Smooth muscle cells, Stim1, Stim2, Synaptotagmin XII, Synaptotagmin XIII, TMEM110, TMEM38B, TorsinB, TRAP-β, TRAP-γ, Troponin I-FS, TXNDC13, vasostatin II, Vgl-2, Vmn1r104, and WDR7.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Cyclopiazonic Acid, 10 mg | sc-201510 | 10 mg | $173.00 | |||
Cyclopiazonic Acid, 50 mg | sc-201510A | 50 mg | $612.00 |