Fam148b Antibody (E-9): sc-390660

Fam148b Antibody (E-9) is a mouse monoclonal IgM antibody that detects Fam148b of human, mouse, and rat origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-Fam148b antibody (E-9) is available as a non-conjugated format. Fam148b plays a crucial role in cellular signaling pathways, particularly in regulating neuronal development and function, which is essential for maintaining proper cognitive and motor functions. Disruptions in these pathways can lead to neurodevelopmental disorders, highlighting Fam148b′s importance in studying conditions like Angelman syndrome and Prader-Willi syndrome, both linked to genetic anomalies in the 15q11-q13 region of chromosome 15. Understanding Fam148b′s function can provide insights into the molecular mechanisms underlying these syndromes and may pave the way for potential therapeutic strategies.

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Fam148b Antibody (E-9) References:

1. Analysis of the DNA sequence and duplication history of human chromosome 15.  |  Zody, MC., et al. 2006. Nature. 440: 671-5. PMID: 16572171
2. Effective gene therapy in an authentic model of Tay-Sachs-related diseases.  |  Cachón-González, MB., et al. 2006. Proc Natl Acad Sci U S A. 103: 10373-10378. PMID: 16801539
3. Pyrimethamine as a potential pharmacological chaperone for late-onset forms of GM2 gangliosidosis.  |  Maegawa, GH., et al. 2007. J Biol Chem. 282: 9150-61. PMID: 17237499
4. Molecular epigenetics of Angelman syndrome.  |  Lalande, M. and Calciano, MA. 2007. Cell Mol Life Sci. 64: 947-60. PMID: 17347796
5. [The Prader-Willi syndrome].  |  Diene, G., et al. 2007. Ann Endocrinol (Paris). 68: 129-37. PMID: 17499572
6. Detailed analysis of 15q11-q14 sequence corrects errors and gaps in the public access sequence to fully reveal large segmental duplications at breakpoints for Prader-Willi, Angelman, and inv dup(15) syndromes.  |  Makoff, AJ. and Flomen, RH. 2007. Genome Biol. 8: R114. PMID: 17573966
7. Fibrillin-rich microfibrils: Structural determinants of morphogenetic and homeostatic events.  |  Ramirez, F. and Dietz, HC. 2007. J Cell Physiol. 213: 326-30. PMID: 17708531
8. Extracellular control of TGFbeta signalling in vascular development and disease.  |  ten Dijke, P. and Arthur, HM. 2007. Nat Rev Mol Cell Biol. 8: 857-69. PMID: 17895899
9. New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk.  |  Dupuis, J., et al. 2010. Nat Genet. 42: 105-16. PMID: 20081858
10. The diabetogenic VPS13C/C2CD4A/C2CD4B rs7172432 variant impairs glucose-stimulated insulin response in 5,722 non-diabetic Danish individuals.  |  Grarup, N., et al. 2011. Diabetologia. 54: 789-94. PMID: 21249489
11. Sexually dimorphic roles for the type 2 diabetes-associated C2cd4b gene in murine glucose homeostasis.  |  Mousavy Gharavy, SN., et al. 2021. Diabetologia. 64: 850-864. PMID: 33492421
12. C2CD4B Evokes Oxidative Stress and Vascular Dysfunction via a PI3K/Akt/PKCα-Signaling Pathway.  |  Di Pietro, P., et al. 2024. Antioxidants (Basel). 13: PMID: 38247525

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Fam148b Antibody (E-9) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-Fam148b Antibody (E-9) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Fam148b Antibody (E-9) Specifications

Alternate Product Name: Fam148b

Product Clone Name: E-9

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 50-71

Epitope Target: Fam148b

Epitope Species: mouse

Product Reactivity/Detection: NLF2 of human origin, Fam148b of mouse origin and the corresponding rat homolog

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for Fam148b Antibody (E-9): P: Blocking Peptide