1,2-Dioctanoyl-sn-glycerol CAS: 60514-48-9
MF: C19H36O5
MW: 344.49

1,2-Dioctanoyl-sn-glycerol (CAS 60514-48-9)

1,2-Dioctanoyl-sn-glycerol | CAS 60514-48-9 is rated 5.0 out of 5 by 1.
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Alternate Names: 1,2-Dioctanoyl-sn-glycerol is also known as 1,2-bis(O-octanoyl)-sn-glycerol.
Application: 1,2-Dioctanoyl-sn-glycerol is a cell-permeable analog of diacylglycerol and activator of protein kinase C (PKC).
CAS Number: 60514-48-9
Purity: ≥95%
Molecular Weight: 344.49
Molecular Formula: C19H36O5
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

1,2-Dioctanoyl-sn-glycerol is a cell-permeable activator of protein kinase C (PKC). 1,2-Dioctanoyl-sn-glycerol exhibits lower affinity for PKCa than for other isozymes. 1,2-Dioctanoyl-sn-glycerol is shown to mimic the effects of tumor-promoting phorbol diesters on mitogenesis and epidermal growth factor binding and action in intact cells. 1,2-Dioctanoyl-sn-glycerol is an analog of the lipid second messenger diacylglycerol (DAG).


References

1. Doherty, C.M., Tarchala, S.M., Radwanska, E., et al.Characterization of two second messenger pathways and their interactions in eliciting the human sperm acrosome reaction. Journal of Andrology 16, 36-46 (1995).
2. Ferro, T.J., et al. 1993. Am. J. Physiol. 264, L7.
3. MacEwan, D.J., et al. 1993. Eur. J. Pharmacol. 246, 9.
4. Davis, R.J. 1985. J. Biol. Chem. 260, 1562.

Formulation :
A solution in acetonitrile
Physical State :
Liquid
Solubility :
Soluble in DMSO (7 mg/ml), chloroform, 100% ethanol, dichloromethane, ether, ethyl acetate, methanol, most organic solvents, DMF (7 mg/ml), PBS (pH 7.2) (250 ug/ml), water (>250 ug/ml at 25° C), and cyclohexane.
Storage :
Store at -80° C
Boiling Point :
81-82° C
Refractive Index :
n20D 1.46 (Predicted)
IC50 :
Protein kinase C alpha: IC50 = 5 µM (mouse); Protein kinase C delta: IC50 = 5 µM (mouse); Protein kinase C gamma: IC50 = 5 µM (mouse); Protein kinase C eta: IC50 = 5 µM (mouse); Protein kinase C beta: IC50 = 5 µM (mouse)
Ki Data :
Protein kinase C alpha: Ki= 33 nM (human)
pK Values :
pKa: 13.70 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
RH0764500
PubChem CID :
148879
MDL Number :
MFCD00036835
Beilstein Registry :
1714754
SMILES :
CCCCCCCC(=O)OC[[email protected]](CO)OC(=O)CCCCCCC

Download SDS (MSDS)

Certificate of Analysis

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What is the concentration of this product?

Asked by: SCchem16
Thank you for your question. This compound is supplied in a solution of acetonitrile at a concentration of 100 mg/ml. If you have any further questions or concerns, please feel free to contact our Technical Service department by calling 800-457-3801 option 2, emailing [email protected], or using the Live Chat function on our website.
Answered by: Tech Service 8
Date published: 2019-09-10
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Rated 5 out of 5 by from Wang T; et al Wang T; et al. (PubMed ID: 22232602) utilized 1,2-Dioctanoyl-sn-glycerol, an activator of PKC, to explain the signaling pathways in bladder smooth muscle contraction. -SCBT Publication Review
Date published: 2015-01-26
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