1,2-Dioctanoyl-sn-glycerol is a cell-permeable activator of protein kinase C (PKC). 1,2-Dioctanoyl-sn-glycerol exhibits lower affinity for PKCa than for other isozymes. 1,2-Dioctanoyl-sn-glycerol is shown to mimic the effects of tumor-promoting phorbol diesters on mitogenesis and epidermal growth factor binding and action in intact cells. 1,2-Dioctanoyl-sn-glycerol is an analog of the lipid second messenger diacylglycerol (DAG).
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