Molecular structure of FPL-64176, CAS Number: 120934-96-5
FPL-64176 (CAS 120934-96-5)
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Alternate Names:
Methyl 4-(2-benzylbenzoyl)-2,5-dimethyl-1H-pyrrole-3-carboxylate
Application:
FPL-64176 is a nondihydropyridine Ca2+ channel activator
CAS Number:
120934-96-5
Purity:
98%
Molecular Weight:
347.41
Molecular Formula:
C22H21NO3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
FPL-64176 is a nondihydropyridine Ca2+ channel activator whose effects differs in some respects from the 1,4-dihydropyridine group of agonists. It may act to enhance contractility and prolong action potential duration in guinea pig papillary muscle. Additionally, it was found to increase Ca2+ current amplitude. Moreover, it has been reported to weakly inhibit (+)-[3H]PN 200-110, [3H]D888, and [3H]TA-3090 binding in rat cardiac membranes.
FPL-64176 (CAS 120934-96-5) References
- Kinetic effects of FPL 64176 on L-type Ca2+ channels in cardiac myocytes. | Fan, JS., et al. 2000. Naunyn Schmiedebergs Arch Pharmacol. 361: 465-76. PMID: 10832599
- FPL-64176 modifies pore properties of L-type Ca(2+) channels. | Fan, J., et al. 2001. Am J Physiol Cell Physiol. 280: C565-72. PMID: 11171576
- Effects of FPL 64176 on Ca transients in voltage-clamped rat ventricular myocytes. | Fan, JS. and Palade, P. 2002. Br J Pharmacol. 135: 1495-504. PMID: 11906963
- Activation of cardiac ryanodine receptors by the calcium channel agonist FPL-64176. | Wasserstrom, JA., et al. 2002. Am J Physiol Heart Circ Physiol. 283: H331-8. PMID: 12063306
- Characterization of the effects of a new Ca2+ channel activator, FPL 64176, in GH3 cells. | Kunze, DL. and Rampe, D. 1992. Mol Pharmacol. 42: 666-70. PMID: 1279375
- The calcium channel ligand FPL 64176 enhances L-type but inhibits N-type neuronal calcium currents. | Liu, L., et al. 2003. Neuropharmacology. 45: 281-92. PMID: 12842134
- Functional interactions between two Ca2+ channel activators, (S)-Bay K 8644 and FPL 64176, in smooth muscle. | Rampe, D. and Dage, RC. 1992. Mol Pharmacol. 41: 599-602. PMID: 1373795
- FPL-64176 alters both charge movement and Ca2+ release properties in amphibian muscle fibres. | Chawla, S. and Huang, CL. 2004. Pflugers Arch. 447: 922-7. PMID: 15061146
- FPL 64176 modification of Ca(V)1.2 L-type calcium channels: dissociation of effects on ionic current and gating current. | McDonough, SI., et al. 2005. Biophys J. 88: 211-23. PMID: 15501945
- A new site for the activation of cardiac calcium channels defined by the nondihydropyridine FPL 64176. | Rampe, D. and Lacerda, AE. 1991. J Pharmacol Exp Ther. 259: 982-7. PMID: 1662279
- Pharmacological, radioligand binding, and electrophysiological characteristics of FPL 64176, a novel nondihydropyridine Ca2+ channel activator, in cardiac and vascular preparations. | Zheng, W., et al. 1991. Mol Pharmacol. 40: 734-41. PMID: 1719369
- Molecular Determinants of the Differential Modulation of Cav1.2 and Cav1.3 by Nifedipine and FPL 64176. | Wang, Y., et al. 2018. Mol Pharmacol. 94: 973-983. PMID: 29980657
- Anti-schistosomal action of the calcium channel agonist FPL-64176. | McCusker, P. and Chan, JD. 2019. Int J Parasitol Drugs Drug Resist. 11: 30-38. PMID: 31561039
- Allosteric interactions at L-type calcium channels between FPL 64176 and the enantiomers of the dihydropyridine Bay K 8644. | Usowicz, MM., et al. 1995. J Pharmacol Exp Ther. 275: 638-45. PMID: 7473149
- Comparison of the in vitro and in vivo cardiovascular effects of two structurally distinct Ca++ channel activators, BAY K 8644 and FPL 64176. | Rampe, D., et al. 1993. J Pharmacol Exp Ther. 265: 1125-30. PMID: 7685384
Activator of:
2610021K21Rik, 4931407G18Rik, 4931409K22Rik, B830028B13Rik, CaBP2, CaBP5, Cacna2d4, CAPS1, CASK, CASPR5, CCDC104, CCDC121, CCDC142, CCDC167, CCDC38, CCDC62, CCDC77, EF-CAB9, Fam148b, ICA69, Junctophilin-1, Junctophilin-3, KCNMB3, KIR2.6, L-type Ca++ CP α1C/1D/1F/1S, L-type Ca++ CP α1F, L-type Ca++ CP α1S, L-type Ca++ CP β1, L-type Ca++ CP β3, L-type Ca++ CP γ8, LIPJ, LOC221710, LRRC49, MIC2L1, MS4A4C, Mtvr1, N-type Ca CP α1B, N-type Ca++ CP α1B, neurexin I, NOC4L, Olr1128, Olr1155, Olr1156, Olr1199, Olr1204, Olr1217, Olr1225, Olr1233, Olr1234, Olr1245, Olr1257, Olr1264, Olr129, Olr1293, Olr130, Olr1320, Olr1323, Olr1331, Olr1350, Olr1383, Olr1385, Olr1398, Olr14, Olr1425, Olr232, Olr235, Olr24, Olr245, Olr251, Olr255, Olr263, p41-ARCa, parvalbumin α, PRAMEF21, PRR21, PTTG2, RBMY1A, Rlf, RNase 8, S-100A2, T-type Ca++ CP α1H, TMEM28, TMEM38A, UNC93A, and WDR31.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
FPL-64176, 5 mg | sc-201491 | 5 mg | $81.00 |