Molecular structure of (±)-Bay K 8644, CAS Number: 71145-03-4
(±)-Bay K 8644 (CAS 71145-03-4)
Alternate Names:
1,4-Dihydro-2,6-dimethyl-5-nitro-4-(2-[trifluoromethyl]phenyl)pyridine-3-carboxylic acid methyl ester
Application:
(±)-Bay K 8644 is an active Ca2+ slow channel agonist
CAS Number:
71145-03-4
Purity:
>98%
Molecular Weight:
356.30
Molecular Formula:
C16H15F3N2O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
(±)-Bay K 8644 is a synthetic compound known for its role as a dihydropyridine calcium channel agonist. This chemical specifically targets L-type calcium channels, which are critical for calcium influx in various cell types, including cardiac and smooth muscle cells as well as neurons. By binding to these channels, (±)-Bay K 8644 enhances their opening probability, leading to an increase in calcium entry into cells. The unique mechanism of (±)-Bay K 8644 lies in its ability to stabilize the open state of the L-type calcium channels. This modulation significantly impacts cellular processes that are dependent on calcium signaling, such as muscle contraction, hormone secretion, and neuronal excitability. The compound achieves this effect by interacting with the alpha-1 subunit of the channel, which is responsible for the voltage-dependent gating and conductance of calcium ions. In research contexts, (±)-Bay K 8644 has been extensively used to study the physiology and pharmacology of calcium channels. It is particularly useful in experiments aimed at understanding the role of calcium channels in cellular signaling and excitable cell function.
(±)-Bay K 8644 (CAS 71145-03-4) References
- Transmission of information from cardiac dihydropyridine receptor to ryanodine receptor: evidence from BayK 8644 effects on resting Ca(2+) sparks. | Katoh, H., et al. 2000. Circ Res. 87: 106-11. PMID: 10903993
- Effects of the enantiomers of BayK 8644 on the charge movement of L-type Ca channels in guinea-pig ventricular myocytes. | Artigas, P., et al. 2003. J Membr Biol. 193: 215-27. PMID: 12962282
- Inhibition of adenosine responses of rat hippocampal neurones by nifedipine and BAYK 8644. | Bartrup, JT. and Stone, TW. 1990. Brain Res. 525: 315-8. PMID: 1701332
- Gating of the HypoPP-1 mutations: II. Effects of a calcium-channel agonist BayK 8644. | Kuzmenkin, A., et al. 2007. Pflugers Arch. 454: 605-14. PMID: 17333247
- NMDAR blockade-induced neonatal brain injury: Reversal by the calcium channel agonist BayK 8644. | Turner, CP., et al. 2009. Neurosci Lett. 450: 292-5. PMID: 19070650
- Conformational changes induced in voltage-gated calcium channel Cav1.2 by BayK 8644 or FPL64176 modify the kinetics of secretion independently of Ca2+ influx. | Marom, M., et al. 2010. J Biol Chem. 285: 6996-7005. PMID: 20054004
- Effect of BayK 8644 on [Ca²⁺]i and viability in PC3 human prostate cancer cells. | Lai, ZR., et al. 2013. Chin J Physiol. 56: 318-25. PMID: 24495178
- Anticonvulsant activity of calmodulin antagonist W-7 in convulsions induced by lindane and BayK-8644: effects in c-fos expression. | Tusell, JM., et al. 1994. Neurotoxicology. 15: 751-6. PMID: 7531829
Inhibitor of:
δ-casein, 1110015M06Rik, 4933404M02Rik, EG546488, LRRC64, Olfr446, Olfr447, Olfr65, Olfr66, Olfr661, Olfr663, Olfr890, Olfr891, Olfr893, Olfr894, Olfr895, OR6P1, Vmn1r129, Vmn1r31, Vmn2r21, and ZIP14.Activator of:
1110007A13Rik, 1110032F04Rik, 1700016L21Rik, 2610021K21Rik, 2B28, 4930408G06Rik, 4930525F21Rik, 4931407G18Rik, 4931409K22Rik, 4931440F15Rik, 4932411E22Rik, 4932411G14Rik, 4932418E24Rik, 9030617O03Rik, 9930021D14Rik, A130010J15Rik, A530032D15Rik, A530082C11Rik, ACTR-I, Adducin β, AE4, Aftiphilin, Annexin III, APRIL-TWEAK, ARL14EPL, BC060267, Bcl11a, BSPII, C030048B08Rik, C10orf67, C10orf95, C11orf16, C14orf143, C19orf24, C19orf52, C2CD4D, C5orf47, CaBP2, CaBP4, CaBP5, CaBP7, CaBP8, Cacna2d2, Cacna2d4, cadherin-24, CALCA, Calcium Channel Protein, CALML4, Calpain 14, CaM IV, CaM V, CaMK1G, CaMKIβ, CaMKIγ, CaMKIIδ, CaMKIIγ, CaMKKβ, CaMKV, CaT1, CatSperβ, CatSperδ, CatSper2, CBF-B, CCDC109A, CCDC109B, CCDC152, CCXCKR, CELF3, CELF6, CIB3, CLCA2, CLCA3_Clac3, CNIH4, COL4A1, copine 8, cryptdin 6, CT47C1, DBX2, Diversin, Dok-1, EF-CAB7, EF-CAB8, EF-CAB9, EF-HB, EF-HC1, EF-HC2, EG331493, EG381582, EG433107, EG631584, EG667705, EG668200, EPB41L5, Eph A8, Fam148b, FAM153B, FAM160A1, FAM26A, FAM59B_Fam59b, FAM71E2, Fat, Fos B, FucT-VIII, GAGE12C, Ggnbp2, Gm1614, Gm410, Gm884, GPR137C, GPR153, GPR154, GRINL1A, GTPBP8, GTRGEO22, HDX, HEATR4, HMGN3, HMP19, HN1, HOM-TES-103, HSV-1 gD, HuB, ICA69, Ichthyin, IFT122, INPP1, Jagged, Josephin-2, JP-45, JRAB, Junctophilin-1, Junctophilin-3, KChIP2, KChIP4, KCNE3, KCNH4, KCNMB3, KIAA1024L_A730017C20Rik, KIAA1166, KIAA1683, KIR2.6, KLF8, KNDC1, KRCC1, KRTAP9, L-type Ca++ CP α1C/1D/1F/1S, L-type Ca++ CP α1D, L-type Ca++ CP α1F, L-type Ca++ CP α1S, L-type Ca++ CP β1, L-type Ca++ CP β3, L-type Ca++ CP γ3, L-type Ca++ CP γ5, L-type Ca++ CP γ7, L-type Ca++ CP γ8, L-type calcium channel α1C, L-type calcium channel α1D, L-type calcium channel α1F, L-type calcium channel β1, LHFPL2, Limkain b1, Lipocalin-12, LIR-4, LIT-1, LOC221710, LOC645781, LRRC25, LRRC26, LRRC55, LRRTM3, M13 Major Coat Protein, MA3, MAGE-A10, MASK-BP3, MBLAC1, MCTP1, MDFI, MIC2L1, MLCKSK, MLEC, MORN5, MS4A4C, MTAC2D1, Mtvr1, Munc13-3, N-twist, N-type Ca CP α1B, N-type Ca++ CP α1B, N-type calcium channel α1B, NALCN, NCS-1, NCU-G1, NCX2, NDST3, Neprilysin-2, Neu4, Neurabin-II, Neurensin-2, neurexin I, NFXL1, NICE-3, NID67, NIPSNAP2, NKD1, Nkx-2.3, NMUR1, NOPE, Obox1, Olfr473, Olfr474, Olfr476, Olfr715, Olfr716, Olfr739, Olr1111, Olr1125, Olr1128, Olr1155, Olr1156, Olr1199, Olr1204, Olr1217, Olr1225, Olr1233, Olr1234, Olr1245, Olr1257, Olr1264, Olr129, Olr1293, Olr130, Olr1320, Olr1323, Olr1331, Olr1350, Olr1383, Olr1385, Olr1398, Olr14, Olr1425, Olr1432, Olr144, Olr1470, Olr1479, Olr1499, Olr1511, Olr1514, Olr1519, Olr1528, Olr1545, Olr1547, Olr1559, Olr1561, Olr1564, Olr1569, Olr1576, Olr159, Olr1591, Olr1595, Olr1602, Olr1620, Olr163, Olr1639, Olr1640, Olr1642, Olr165, Olr1664, Olr170, Olr1714, Olr1733, Olr1748, Olr180, Olr185, Olr193, Olr203, Olr210, Olr213, Olr222, Olr226, Olr232, Olr235, Olr24, Olr245, Olr251, Olr255, Olr263, Olr267, Olr270, Olr282, Olr29, Olr307, Olr32, Olr326, Olr34, Olr354, Olr358, Olr361, Olr367, Olr374, Olr382, Olr395, Olr401, Olr404, Olr409, Olr413, Olr418, Olr420, Olr424, Olr437, Olr443, Olr463, Olr482, Olr484, Olr496, Olr507, Olr516, Olr526, Olr532, Olr541, Olr552, Olr556, Olr559, Olr561, Olr575, Olr592, Olr601, Olr608, Olr611, Olr619, Olr634, Olr639, Olr653, Olr657, Olr665, Olr672, Olr690, Olr696, Olr704, Olr709, Olr712, Olr716, Olr724, Olr727, Olr733, Olr736, Olr742, Olr747, Olr749, Olr766, Olr769, Olr773, Olr785, Olr791, Olr80, Olr806, Olr81, Olr831, Olr836, Olr853, Olr879, Olr905, Olr920, Olr951, Olr962, Olr982, OR1J2, OR2AP1, OR4K13, OR8U9, ORF67, OTRPC4, OTTMUSG00000010009, OTTMUSG00000010173, OTTMUSG00000010433, OTTMUSG00000010673, OTTMUSG00000011070, OTTMUSG00000013284, OTTMUSG00000016588, P/Q-type Ca++ CP α1A, P/Q-type calcium channel α1A, P117, p60TRP, PAFAH1B2, parvalbumin α, PATE-G, Pbx2, PCDHB13, PCDHB16, Pcdhb20, Pellino 1, phospholamban, PIG-YL, PLP-B, PLP-Cβ, PLP-Cδ, PLP-F, PP2B-Aγ, PRAMEF21, PRB1-3, protein phosphatase (PPP3R1 PPP3R2), PRR21, PRRG3, PRRT4, PSM, PSTPIP1, PTN, PTTG2, R-type Ca++ CP α1E, R-type calcium channel α1E, RBMY1A, REM, RGAG4, RGS10, Rhox7, Rhox9, RHOXF1, RIM-BP2, RIM-BP3, RNase 8, RNF11, ROPN1L, S-100A2, S-100Z, Secretoneurin, Sg II, Shigatoxin 2, SHISA6, Siglec-H, SLC17A2, SMIM10, SPACA4, SPANX-D, SPANX-N3, SPATA24, SSTR3, Synaptotagmin X, Synaptotagmin XIII, Synaptotagmin XV, Synaptotagmin XVI, Synaptotagmin XVII, T-type Ca++ CP α1G, T-type calcium channel α1G, T-type calcium channel α1I, TALK-2, TMCO6, TMEM130, TMEM157, TMEM167, TMEM179, TMEM184B, TMEM185A, TMEM190, TMEM203, TMEM206, TMEM229B, TMEM231, TMEM248, TMEM31, TMEM63C, TORC3, TRIM30B, Trp4, TRPC4AP, UNC-79, UNC93A, V1rd8, V1RE1, V1RE13, V1RH9, V1RI10, V1RI3, V1RI5, V3R 10, VAMP-1, VAMP-3, VGAT, VGF, Vmn1r104, Vmn2r109, Vmn2r111, Vmn2r113, Vmn2r115, Vmn2r15, Vmn2r8, Vmn2r97, Vmn2r99, VWA3A, VWC2L, WCRF, WDR43, WFDC10, WFDC17, WFDC1A, X11β, ZDHHC1, ZNF191, ZNF227, ZNF228, ZNF530, ZNF582, ZNF75, and ZSCAN4C.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
(±)-Bay K 8644, 1 mg | sc-203324 | 1 mg | $84.00 | |||
(±)-Bay K 8644, 5 mg | sc-203324A | 5 mg | $196.00 | |||
(±)-Bay K 8644, 50 mg | sc-203324B | 50 mg | $817.00 |