(+/-)-Bay K 8644 CAS: 71145-03-4
MF: C16H15F3N2O4
MW: 356.30
An active Ca2+ slow channel agonist.

(±)-Bay K 8644 (CAS 71145-03-4)

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Alternate Names: 1,4-Dihydro-2,6-dimethyl-5-nitro-4-(2-[trifluoromethyl]phenyl)pyridine-3-carboxylic acid methyl ester
Application: (±)-Bay K 8644 is an active Ca2+ slow channel agonist
CAS Number: 71145-03-4
Purity: >98%
Molecular Weight: 356.30
Molecular Formula: C16H15F3N2O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

(±)-Bay K 8644 is a L-type Ca2+-channel activator (EC50 = 17.3 nM) with positive inotropic, vasoconstrictive and behavioral effects in vivo. When used with BIX-01294 (sc-293525), (±)-Bay K 8644 helps generate induced pluripotent stem cells (iPSCs) from mouse embryonic fibroblasts (MEFs). (±)-Bay K 8644 also inhibits autophagy.


References

1. Wang, W., et al. 2009. Proc. Natl. Acad. Sci. USA 106, 1427. 2. Weigl, L.G., et al. 2000. J. Physiol. 525 (pt. 2), 461. 3. Vannier, C., et al. 1995. Am. J. Physiol. 268, L201. 4. Bechem, M., and Hoffmann, H. 1993. Pflugers Arch. 424, 343. 5. Triggle, D.J., and Rompe, D. 1989. Trends Pharmacol. Sci. 10, 507. 6. Takasu, N., et al. 1987. Biochem. Biophys. Res. Commun. 143, 1107. 7. Tagliatela, M., et al. 1986. Brain Res. 381, 356. 8. Franckowiak, G., et al. 1985. Eur. J. Pharmacol. 114, 223.

Physical State :
Solid
Solubility :
Soluble in DMSO (20 mg/ml), methanol (63 mg/ml), ethanol (63 mg/ml), dichloromethane, and DMF. Insoluble in water.
Storage :
Store at 4° C
Melting Point :
168-170° C
Boiling Point :
~429.17° C at 760 mmHg (Predicted)
Density :
~1.4 g/cm3 (Predicted)
Refractive Index :
n20D 1.54 (Predicted)
IC50 :
L-type Ca2+-channel : EC5050 = 17.3 nM; Cavia porcellus: IC50 = 230 nM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
US5655000
PubChem CID :
2303
MDL Number :
MFCD00036697
SMILES :
CC1=C(C(C(=C(N1)C)[N+](=O)[O-])C2=CC=CC=C2C(F)(F)F)C(=O)OC

Download SDS (MSDS)

Certificate of Analysis

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