Date published: 2026-5-6

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SH-PTP Antibodies

Santa Cruz Biotechnology supplies a comprehensive collection of SH-PTP monoclonal antibodies for investigating SH-PTP proteins in cellular signaling pathways. The monoclonal antibodies are suitable for multiple applications, including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), flow cytometry (FCM), and enzyme-linked immunosorbent assay (ELISA). SH-PTP proteins, or Src homology domain-containing protein tyrosine phosphatases, regulate cellular processes such as growth, differentiation, and metabolism by dephosphorylating tyrosine residues on target proteins. Dysregulation of SH-PTP proteins has been linked to various diseases, including cancer and autoimmune disorders, highlighting their importance as therapeutic targets. Research focused on SH-PTP proteins continues to reveal new insights into disease mechanisms and potential treatment approaches. Advanced detection methods using monoclonal antibodies enable precise identification and characterization of SH-PTP proteins in various experimental settings. Extensive quality standards ensure reliable and reproducible results in SH-PTP protein research. Understanding SH-PTP protein function and regulation advances knowledge of cellular signaling networks and disease pathways. Santa Cruz Biotechnology monoclonal antibodies for SH-PTP proteins support researchers worldwide in advancing scientific understanding of cellular signaling and disease mechanisms.

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SH-PTP Antibodies

Empty Table HeaderProduct NameCATALOG #ISOTYPEEPITOPEAPPLICATIONSSpeciesCitationsRATING

SH-PTP1 Antibody (D-11)

sc-7289mouse IgG3 κC-terminal (h)WB, IP, IF, IHC(P), FCM, ELISAm, r, h
60
(20)

SH-PTP1 Antibody (D-7)

sc-271329mouse IgG1 κ356-420 (h)WB, IP, IF, IHC(P), ELISAm, r, h
1
(1)

SH-PTP1 Antibody (PTY6)

sc-52885mouse IgG1 κFL (h)WB, IP, IF, ELISAh
1
(2)

SH-PTP1 Antibody (PTY11)

sc-56964mouse IgG1 κFL (h)WB, IP, IF, ELISAh
1
(1)

SH-PTP1 Antibody (PTY15)

sc-52890mouse IgG1 κFL (h)WB, IP, IF, ELISAm, r, h

new

(2)

SH-PTP2 Antibody (B-1)

sc-7384mouse IgG1 κ580-597 (h)WB, IP, IF, IHC(P), FCM, ELISAm, r, h
123
(26)

SH-PTP2 Antibody (D-3)

sc-271053mouse IgG1 κ6-213 (h)WB, IP, IF, IHC(P), ELISAm, r, h
1
(2)

SH-PTP2 Antibody (D-1)

sc-271106mouse IgG1 κ373-404 (h)WB, IP, IF, ELISAm, r, h
2
(3)

SH-PTP2 Antibody (H-2)

sc-271550mouse IgG1 κ373-404 (h)WB, IP, IF, ELISAm, r, h

new

(1)

Phospho-Specific SH-PTP Antibodies

Empty Table HeaderProduct NameCATALOG #ISOTYPEEPITOPEAPPLICATIONSSpeciesCitationsRATING

p-SH-PTP1 Antibody (14.Tyr 536)

sc-135780mouse IgG1 κTyr 536 (h)WB, IP, ELISAm, r, h
1
(2)

p-SH-PTP2 Antibody (49.Tyr 542)

sc-293147mouse IgG1 κTyr 542 (h)WB, IP, ELISAh
2
(2)

SH-PTP CRISPR Knockout, HDR and Double Nickase Plasmids

Empty Table HeaderProduct NameCATALOG #SpeciesAPPLICATIONSMARKERCitationsRATING

SH-PTP1 CRISPR/Cas9 KO Plasmid (h2)

sc-400369-KO-2hGene KnockoutGFP0
(0)

SH-PTP1 HDR Plasmid (h2)

sc-400369-HDR-2hHomology Directed RepairPuromycin0
(0)

SH-PTP1 Double Nickase Plasmid (h)

sc-400369-NIChGene KnockoutPuromycin0
(0)

SH-PTP1 Double Nickase Plasmid (h2)

sc-400369-NIC-2hGene KnockoutPuromycin0
(0)

SH-PTP2 CRISPR/Cas9 KO Plasmid (h)

sc-400260hGene KnockoutGFP
1
(0)

SH-PTP2 HDR Plasmid (h)

sc-400260-HDRhHomology Directed RepairPuromycin
1
(0)

SH-PTP2 Double Nickase Plasmid (h)

sc-400260-NIChGene KnockoutPuromycin
1
(0)

SH-PTP2 Double Nickase Plasmid (h2)

sc-400260-NIC-2hGene KnockoutPuromycin
1
(0)

SH-PTP2 CRISPR/Cas9 KO Plasmid (m2)

sc-422503-KO-2mGene KnockoutGFP0
(0)

SH-PTP2 HDR Plasmid (m2)

sc-422503-HDR-2mHomology Directed RepairPuromycin0
(0)

SH-PTP2 Double Nickase Plasmid (m)

sc-422503-NICmGene KnockoutPuromycin0
(0)

SH-PTP2 Double Nickase Plasmid (m2)

sc-422503-NIC-2mGene KnockoutPuromycin0
(0)

SH-PTP CRISPR Activation Products

Empty Table HeaderProduct NameCATALOG #SpeciesAPPLICATIONSMARKERCitationsRATING

SH-PTP2 CRISPR Activation Plasmid (h)

sc-400260-ACThGene ActivationPuro, Blast, Hygro
1
(0)

SH-PTP2 CRISPR Activation Plasmid (h2)

sc-400260-ACT-2hGene ActivationPuro, Blast, Hygro
1
(0)

SH-PTP siRNA, shRNA Plasmid and shRNA Lentiviral Particle Gene Silencers

Empty Table HeaderProduct NameCATALOG #SpeciesAPPLICATIONSMARKERCitationsRATING

SH-PTP1 siRNA (h)

sc-29478hGene SilencingN/A
14
(3)

SH-PTP1 siRNA (h2)

sc-270492hGene SilencingN/A0
(0)

SH-PTP1 shRNA Plasmid (h)

sc-29478-SHhGene SilencingPuromycin
14
(3)

SH-PTP1 shRNA Plasmid (h2)

sc-270492-SHhGene SilencingPuromycin0
(0)

SH-PTP1 shRNA (h) Lentiviral Particles

sc-29478-VhGene SilencingPuromycin
14
(3)

SH-PTP1 shRNA (h2) Lentiviral Particles

sc-270492-VhGene SilencingPuromycin0
(0)

SH-PTP1 siRNA (m)

sc-29479mGene SilencingN/A
9
(0)

SH-PTP1 shRNA Plasmid (m)

sc-29479-SHmGene SilencingPuromycin
9
(0)

SH-PTP1 shRNA (m) Lentiviral Particles

sc-29479-VmGene SilencingPuromycin
9
(0)

SH-PTP1 siRNA (r)

sc-270044rGene SilencingN/A
1
(0)

SH-PTP1 shRNA Plasmid (r)

sc-270044-SHrGene SilencingPuromycin
1
(0)

SH-PTP1 shRNA (r) Lentiviral Particles

sc-270044-VrGene SilencingPuromycin
1
(0)

SH-PTP2 siRNA (h)

sc-36488hGene SilencingN/A
21
(2)

SH-PTP2 shRNA Plasmid (h)

sc-36488-SHhGene SilencingPuromycin
21
(2)

SH-PTP2 shRNA (h) Lentiviral Particles

sc-36488-VhGene SilencingPuromycin
21
(2)

SH-PTP2 siRNA (m)

sc-36489mGene SilencingN/A
3
(0)

SH-PTP2 shRNA Plasmid (m)

sc-36489-SHmGene SilencingPuromycin
3
(0)

SH-PTP2 shRNA (m) Lentiviral Particles

sc-36489-VmGene SilencingPuromycin
3
(0)

SH-PTP2 siRNA (r)

sc-270045rGene SilencingN/A
3
(0)

SH-PTP2 shRNA Plasmid (r)

sc-270045-SHrGene SilencingPuromycin
3
(0)

SH-PTP2 shRNA (r) Lentiviral Particles

sc-270045-VrGene SilencingPuromycin
3
(0)