p-SH-PTP2 Antibody (49.Tyr 542): sc-293147

p-SH-PTP2 (49.Tyr 542) is a mouse monoclonal IgG1 kappa light chain antibody that detects Tyr 542 phosphorylated SH-PTP2 of human origin by western blotting (WB), immunoprecipitation (IP) and enzyme-linked immunosorbent assay (ELISA). p-SH-PTP2 (clone 49.Tyr 542) antibody is available in both conjugated and non-conjugated forms. The steady state of protein tyrosyl phosphorylation in cells is regulated by the opposing action of tyrosine kinases and protein tyrosine phosphatases (PTPs). Several groups have independently identified a non-transmembrane PTP, designated SH-PTP1 (also known as PTP1C, HCP and SHP), which is primarily expressed in hematopoietic cells and characterized by the presence of two SH2 domains N-terminal to the PTP domain. SH2 domains generally mediate the association of regulatory molecules with specific phosphotyrosine-containing sites on autophosphorylated receptors, thereby controlling the initial interaction of receptors with these substrates. A second and much more widely expressed PTP with SH2 domains, SH-PTP2 (also designated PTP1D and Syp), has been identified. Strong sequence similarity between SH-PTP2 and the Drosophila gene corkscrew (CSW) and their similar patterns of expression suggest that SH-PTP2 is the human corkscrew homolog.

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p-SH-PTP2 Antibody (49.Tyr 542) References:

1. Identification of a human src homology 2-containing protein-tyrosine-phosphatase: a putative homolog of Drosophila corkscrew.  |  Freeman, RM., et al. 1992. Proc Natl Acad Sci U S A. 89: 11239-43. PMID: 1280823
2. Characterization of hematopoietic intracellular protein tyrosine phosphatases: description of a phosphatase containing an SH2 domain and another enriched in proline-, glutamic acid-, serine-, and threonine-rich sequences.  |  Matthews, RJ., et al. 1992. Mol Cell Biol. 12: 2396-405. PMID: 1373816
3. A protein-tyrosine phosphatase with sequence similarity to the SH2 domain of the protein-tyrosine kinases.  |  Shen, SH., et al. 1991. Nature. 352: 736-9. PMID: 1652101
4. Protein tyrosine phosphatase containing SH2 domains: characterization, preferential expression in hematopoietic cells, and localization to human chromosome 12p12-p13.  |  Yi, TL., et al. 1992. Mol Cell Biol. 12: 836-46. PMID: 1732748
5. Isolation of a src homology 2-containing tyrosine phosphatase.  |  Plutzky, J., et al. 1992. Proc Natl Acad Sci U S A. 89: 1123-7. PMID: 1736296
6. Cloning of a cDNA for a major human protein-tyrosine-phosphatase.  |  Chernoff, J., et al. 1990. Proc Natl Acad Sci U S A. 87: 2735-9. PMID: 2157211
7. Activation of a phosphotyrosine phosphatase by tyrosine phosphorylation.  |  Vogel, W., et al. 1993. Science. 259: 1611-4. PMID: 7681217
8. SH2-containing phosphotyrosine phosphatase as a target of protein-tyrosine kinases.  |  Feng, GS., et al. 1993. Science. 259: 1607-11. PMID: 8096088

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-p-SH-PTP2 Antibody (49.Tyr 542) has 2 citations in a variety of scientific publications.

Primary antibodies like Anti-p-SH-PTP2 Antibody (49.Tyr 542) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

p-SH-PTP2 Antibody (49.Tyr 542) Specifications

Alternate Product Name: PTPN11

Product Clone Name: 49.Tyr 542

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: Tyr 542

Epitope Target: SH-PTP2

Epitope Species: human

Product Reactivity/Detection: Tyr 542 phosphorylated SH-PTP2

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for p-SH-PTP2 Antibody (49.Tyr 542): AC: Agarose, HRP: Horseradish Peroxidase

The preferred SH-PTP2 antibody is SH-PTP2 Antibody (B-1): sc-7384.