SH-PTP1 Antibody (D-11): sc-7289

SH-PTP1 Antibody (D-11) is a mouse monoclonal IgG3 kappa light chain antibody that detects SH-PTP1 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin embedded sections (IHCP), flow cytometry (FCM), and enzyme-linked immunosorbent assay (ELISA). SH-PTP1 Antibody (D-11) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. SH-PTP1, also known as protein tyrosine phosphatase non-receptor type 6, plays a crucial role in regulating cellular signaling pathways by dephosphorylating tyrosine residues on target proteins, which is essential for maintaining the balance of tyrosine phosphorylation in cells. This regulation is particularly important in hematopoietic cells, where SH-PTP1 modulates the activity of various signaling pathways involved in cell growth, differentiation, and immune responses. The presence of two SH2 domains in SH-PTP1 enables interaction with specific phosphotyrosine-containing sites on autophosphorylated receptors, thereby influencing the downstream signaling events that are critical for cellular function. Understanding the role of SH-PTP1 in these processes can provide insights into potential implications in diseases such as cancer and autoimmune disorders, making SH-PTP1 (D-11) antibody a valuable tool for researchers studying these conditions.

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SH-PTP1 Antibody (D-11) References:

1. Identification of a human src homology 2-containing protein-tyrosine-phosphatase: a putative homolog of Drosophila corkscrew.  |  Freeman, RM., et al. 1992. Proc Natl Acad Sci U S A. 89: 11239-43. PMID: 1280823
2. Characterization of hematopoietic intracellular protein tyrosine phosphatases: description of a phosphatase containing an SH2 domain and another enriched in proline-, glutamic acid-, serine-, and threonine-rich sequences.  |  Matthews, RJ., et al. 1992. Mol Cell Biol. 12: 2396-405. PMID: 1373816
3. A protein-tyrosine phosphatase with sequence similarity to the SH2 domain of the protein-tyrosine kinases.  |  Shen, SH., et al. 1991. Nature. 352: 736-9. PMID: 1652101
4. Protein tyrosine phosphatase containing SH2 domains: characterization, preferential expression in hematopoietic cells, and localization to human chromosome 12p12-p13.  |  Yi, TL., et al. 1992. Mol Cell Biol. 12: 836-46. PMID: 1732748
5. Isolation of a src homology 2-containing tyrosine phosphatase.  |  Plutzky, J., et al. 1992. Proc Natl Acad Sci U S A. 89: 1123-7. PMID: 1736296
6. Cloning of a cDNA for a major human protein-tyrosine-phosphatase.  |  Chernoff, J., et al. 1990. Proc Natl Acad Sci U S A. 87: 2735-9. PMID: 2157211
7. Valproic acid increases NO production via the SH-PTP1-CDK5-eNOS-Ser(116) signaling cascade in endothelial cells and mice.  |  Cho, DH., et al. 2014. Free Radic Biol Med. 76: 96-106. PMID: 25150199
8. Intramolecular regulation of protein tyrosine phosphatase SH-PTP1: a new function for Src homology 2 domains.  |  Pei, D., et al. 1994. Biochemistry. 33: 15483-93. PMID: 7528537
9. Activation of a phosphotyrosine phosphatase by tyrosine phosphorylation.  |  Vogel, W., et al. 1993. Science. 259: 1611-4. PMID: 7681217
10. SH2-containing phosphotyrosine phosphatase as a target of protein-tyrosine kinases.  |  Feng, GS., et al. 1993. Science. 259: 1607-11. PMID: 8096088
11. Lck-dependent tyrosyl phosphorylation of the phosphotyrosine phosphatase SH-PTP1 in murine T cells.  |  Lorenz, U., et al. 1994. Mol Cell Biol. 14: 1824-34. PMID: 8114715
12. Differential functions of the two Src homology 2 domains in protein tyrosine phosphatase SH-PTP1.  |  Pei, D., et al. 1996. Proc Natl Acad Sci U S A. 93: 1141-5. PMID: 8577729

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-SH-PTP1 Antibody (D-11) has 60 citations in a variety of scientific publications.

Primary antibodies like Anti-SH-PTP1 Antibody (D-11) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

SH-PTP1 Antibody (D-11) Specifications

Alternate Product Name: SHP-1

Product Clone Name: D-11

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₃ kappa light chain

Amino Acids: 576-595

Epitope Target: SH-PTP1

Epitope Species: human

Product Reactivity/Detection: SH-PTP1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: canine and porcine

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), FCM, ELISA

Vialing Information: Each vial contains 200 µg IgG₃ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 60 citations in various scientific publications

Available Conjugates/Forms for SH-PTP1 Antibody (D-11): AC: Agarose, AF488: Alexa Fluor^® 488, AF647: Alexa Fluor^® 647, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin