Date published: 2026-5-5

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Complement Pathway Protein Antibodies

Santa Cruz Biotechnology features a diverse variety of Complement Pathway Protein monoclonal antibodies for researchers studying the complement system's role in immune response and inflammation. Complement Pathway Protein Antibodies are compatible with multiple techniques, including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), flow cytometry (FCM), and enzyme-linked immunosorbent assay (ELISA). The complement pathway is a crucial component of the innate immune system, playing a significant role in pathogen recognition, opsonization, and the promotion of inflammation. By facilitating the clearance of pathogens and damaged cells, complement proteins help maintain homeostasis and protect against infections. Dysregulation of the complement system has been implicated in various diseases, including autoimmune disorders and chronic inflammatory conditions. Researchers can explore the complex interactions between complement proteins and their binding partners through detailed molecular analyses. Advanced imaging techniques combined with specific monoclonal antibodies enable visualization of complement protein distribution in various tissues and cellular compartments. Understanding complement pathway regulation and activation mechanisms provides valuable insights into potential therapeutic targets. Santa Cruz Biotechnology monoclonal antibodies for complement pathway proteins support researchers worldwide in advancing our understanding of immune system function and disease treatment strategies.

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Complement Pathway Protein Antibodies

Empty Table HeaderProduct NameCATALOG #ISOTYPEEPITOPEAPPLICATIONSSpeciesCitationsRATING

Activated C3 Antibody (I3/15)

sc-47687mouse IgG1 κFL (h)WB, IPh
3
(1)

C3 Antibody (B-9)

sc-28294mouse IgG1 κ541-840 (h)WB, IP, IF, IHC(P), ELISAm, r, h
59
(16)

C3 Antibody (2898)

sc-52629mouse IgG1C-Terminal (h)WB, IPh
3
(1)

C3 Antibody (A-4)

sc-55458mouse IgG1 κ541-840 (h)WB, IP, IF, ELISAh
1
(4)

C3 Antibody (C-4)

sc-25298mouse IgG2a κ541-840 (h)WB, IP, IF, ELISAh
1
(3)

C3 Antibody (11H9)

sc-58926rat IgG2a(m)WB, IP, IF, FCMm
19
(3)

C3a Antibody (K13/16)

sc-47688mouse IgG1 κFL (h)WB, IP, IF, IHC(P)h
4
(3)

C3a Antibody (D17/1)

sc-47689mouse IgG1 κFL 21038(h)WB, IPh

new

(1)

C3aR Antibody (D-12)

sc-133172mouse IgG2a κ183-482 (h)WB, IP, IF, ELISAm, r, h
27
(7)

C3aR Antibody (17)

sc-53782mouse IgG2b κ(h)WB, IP, IF, FCMh
4
(1)

C3aR Antibody (74)

sc-53785mouse IgG1 κ(r)IF, FCMm, r
2
(1)

C4 Antibody (16D2)

sc-58930rat IgG2a(m)WB, IP, IF, FCMm
4
(3)

C4α Antibody (C-2)

sc-271181mouse IgG1 κ1146-1300 (h)WB, IP, IF, ELISAm, r, h
5
(3)

C4β Antibody (D-12)

sc-74524mouse IgG2a κ376-675 (h)WB, IP, IF, ELISAm, r, h
2
(3)

C5β Antibody (E-8)

sc-398247mouse IgG2a κ562-589 (h)WB, IP, IF, ELISAm, r, h
4
(3)

C5b-9 Antibody (2A1)

sc-66190mouse IgG1 κ(r)WB, IFm, r
12
(3)

C5L2 Antibody (E-8)

sc-515734mouse IgG1 κ2-26 (h)WB, IP, IF, ELISAm, r, h
1
(2)

C6 Antibody (D-8)

sc-390735mouse IgG2b κ118-360 (h)WB, IP, IF, ELISAh
1
(1)

C6 Antibody (B-3)

sc-390716mouse IgG1 κ(h)WB, IP, IF, ELISAh

new

(1)

C6 Antibody (3G11)

sc-66191mouse IgG1 κ(r)WBm, r

new

(1)

C8γ Antibody (H-10)

sc-515150mouse IgG2b κ138-202 (h)WB, IP, IF, ELISAh

new

(1)

C9 Antibody (E-3)

sc-390000mouse IgG1 κ350-559 (h)WB, IP, IF, IHC(P), ELISAh
7
(4)

Complement Pathway Protein CRISPR Knockout, HDR and Double Nickase Plasmids

Empty Table HeaderProduct NameCATALOG #SpeciesAPPLICATIONSMARKERCitationsRATING

C3 CRISPR/Cas9 KO Plasmid (h)

sc-400622hGene KnockoutGFP0
(0)

C3 HDR Plasmid (h)

sc-400622-HDRhHomology Directed RepairPuromycin0
(0)

C3 Double Nickase Plasmid (h)

sc-400622-NIChGene KnockoutPuromycin0
(0)

C3 Double Nickase Plasmid (h2)

sc-400622-NIC-2hGene KnockoutPuromycin0
(0)

C3 CRISPR/Cas9 KO Plasmid (m)

sc-419391mGene KnockoutGFP0
(0)

C3 HDR Plasmid (m)

sc-419391-HDRmHomology Directed RepairPuromycin0
(0)

C3 Double Nickase Plasmid (m)

sc-419391-NICmGene KnockoutPuromycin0
(0)

C3aR CRISPR/Cas9 KO Plasmid (h)

sc-401448hGene KnockoutGFP0
(0)

C3aR HDR Plasmid (h)

sc-401448-HDRhHomology Directed RepairPuromycin0
(0)

C3aR Double Nickase Plasmid (h)

sc-401448-NIChGene KnockoutPuromycin0
(0)

C3aR Double Nickase Plasmid (h2)

sc-401448-NIC-2hGene KnockoutPuromycin0
(0)

C3aR CRISPR/Cas9 KO Plasmid (m)

sc-419392mGene KnockoutGFP0
(0)

C4a CRISPR/Cas9 KO Plasmid (h)

sc-402428hGene KnockoutGFP0
(0)

C4a Double Nickase Plasmid (h)

sc-402428-NIChGene KnockoutPuromycin0
(0)

C4a Double Nickase Plasmid (h2)

sc-402428-NIC-2hGene KnockoutPuromycin0
(0)

C4b Double Nickase Plasmid (h)

sc-416372-NIChGene KnockoutPuromycin0
(0)

C4b Double Nickase Plasmid (h2)

sc-416372-NIC-2hGene KnockoutPuromycin0
(0)

C4b CRISPR/Cas9 KO Plasmid (m)

sc-419393mGene KnockoutGFP0
(0)

C4b HDR Plasmid (m)

sc-419393-HDRmHomology Directed RepairPuromycin0
(0)

C5 HDR Plasmid (h)

sc-401533-HDRhHomology Directed RepairPuromycin0
(0)

C5 Double Nickase Plasmid (h)

sc-401533-NIChGene KnockoutPuromycin0
(0)

C5 Double Nickase Plasmid (h2)

sc-401533-NIC-2hGene KnockoutPuromycin0
(0)

C5 CRISPR/Cas9 KO Plasmid (m)

sc-420806mGene KnockoutGFP0
(0)

C5 HDR Plasmid (m)

sc-420806-HDRmHomology Directed RepairPuromycin0
(0)

C6 Double Nickase Plasmid (h)

sc-404236-NIChGene KnockoutPuromycin0
(0)

C6 Double Nickase Plasmid (h2)

sc-404236-NIC-2hGene KnockoutPuromycin0
(0)

C6 CRISPR/Cas9 KO Plasmid (m)

sc-419396mGene KnockoutGFP0
(0)

C7 Double Nickase Plasmid (h)

sc-404773-NIChGene KnockoutPuromycin0
(0)

C7 Double Nickase Plasmid (h2)

sc-404773-NIC-2hGene KnockoutPuromycin0
(0)

C8β CRISPR/Cas9 KO Plasmid (h)

sc-408409hGene KnockoutGFP0
(0)

C8A CRISPR/Cas9 KO Plasmid (h)

sc-406590hGene KnockoutGFP0
(0)

C5L2 CRISPR/Cas9 KO Plasmid (h)

sc-410578hGene KnockoutGFP
1
(0)

Complement Pathway Protein CRISPR Activation Products

Empty Table HeaderProduct NameCATALOG #SpeciesAPPLICATIONSMARKERCitationsRATING

C3 CRISPR Activation Plasmid (h)

sc-400622-ACThGene ActivationPuro, Blast, Hygro0
(0)

C3 CRISPR Activation Plasmid (m2)

sc-419391-ACT-2mGene ActivationPuro, Blast, Hygro0
(0)

C3 Lentiviral Activation Particles (m2)

sc-419391-LAC-2mGene ActivationPuro, Blast, Hygro0
(0)

C3aR CRISPR Activation Plasmid (h)

sc-401448-ACThGene ActivationPuro, Blast, Hygro0
(0)

C3aR CRISPR Activation Plasmid (h2)

sc-401448-ACT-2hGene ActivationPuro, Blast, Hygro0
(0)

C4a CRISPR Activation Plasmid (h)

sc-402428-ACThGene ActivationPuro, Blast, Hygro0
(0)

C5 CRISPR Activation Plasmid (h)

sc-401533-ACThGene ActivationPuro, Blast, Hygro0
(0)

C5 Lentiviral Activation Particles (h)

sc-401533-LAChGene ActivationPuro, Blast, Hygro0
(0)

C7 CRISPR Activation Plasmid (h)

sc-404773-ACThGene ActivationPuro, Blast, Hygro0
(0)

Complement Pathway Protein siRNA, shRNA Plasmid and shRNA Lentiviral Particle Gene Silencers

Empty Table HeaderProduct NameCATALOG #SpeciesAPPLICATIONSMARKERCitationsRATING

C1rL siRNA (h)

sc-96010hGene SilencingN/A0
(0)

C1rL shRNA Plasmid (h)

sc-96010-SHhGene SilencingPuromycin0
(0)

C1rL shRNA (h) Lentiviral Particles

sc-96010-VhGene SilencingPuromycin0
(0)

C3 siRNA (h)

sc-37068hGene SilencingN/A0
(0)

C3 shRNA Plasmid (h)

sc-37068-SHhGene SilencingPuromycin0
(0)

C3 shRNA (h) Lentiviral Particles

sc-37068-VhGene SilencingPuromycin0
(0)

C3 siRNA (m)

sc-37069mGene SilencingN/A
3
(0)

C3 shRNA Plasmid (m)

sc-37069-SHmGene SilencingPuromycin
3
(0)

C3 shRNA (m) Lentiviral Particles

sc-37069-VmGene SilencingPuromycin
3
(0)

C3aR siRNA (h)

sc-42840hGene SilencingN/A
2
(0)

C3aR shRNA Plasmid (h)

sc-42840-SHhGene SilencingPuromycin
2
(0)

C3aR shRNA (h) Lentiviral Particles

sc-42840-VhGene SilencingPuromycin
2
(0)

C3aR siRNA (m)

sc-42841mGene SilencingN/A0
(0)

C3aR shRNA Plasmid (m)

sc-42841-SHmGene SilencingPuromycin0
(0)

C3aR shRNA (m) Lentiviral Particles

sc-42841-VmGene SilencingPuromycin0
(0)

C4 siRNA (h)

sc-42844hGene SilencingN/A0
(0)

C4 shRNA Plasmid (h)

sc-42844-SHhGene SilencingPuromycin0
(0)

C4 shRNA (h) Lentiviral Particles

sc-42844-VhGene SilencingPuromycin0
(0)

C4 siRNA (m)

sc-42845mGene SilencingN/A0
(0)

C4 shRNA Plasmid (m)

sc-42845-SHmGene SilencingPuromycin0
(0)

C4 shRNA (m) Lentiviral Particles

sc-42845-VmGene SilencingPuromycin0
(0)

C5 siRNA (h)

sc-42848hGene SilencingN/A0
(0)

C5 shRNA Plasmid (h)

sc-42848-SHhGene SilencingPuromycin0
(0)

C5 shRNA (h) Lentiviral Particles

sc-42848-VhGene SilencingPuromycin0
(0)

C5 siRNA (m)

sc-42849mGene SilencingN/A
1
(0)

C5 shRNA Plasmid (m)

sc-42849-SHmGene SilencingPuromycin
1
(0)

C5 shRNA (m) Lentiviral Particles

sc-42849-VmGene SilencingPuromycin
1
(0)

C6 siRNA (h)

sc-72769hGene SilencingN/A0
(0)

C6 shRNA Plasmid (h)

sc-72769-SHhGene SilencingPuromycin0
(0)

C6 shRNA (h) Lentiviral Particles

sc-72769-VhGene SilencingPuromycin0
(0)

C6 siRNA (m)

sc-72770mGene SilencingN/A0
(0)

C6 shRNA Plasmid (m)

sc-72770-SHmGene SilencingPuromycin0
(0)

C6 shRNA (m) Lentiviral Particles

sc-72770-VmGene SilencingPuromycin0
(0)

C7 siRNA (h)

sc-91855hGene SilencingN/A0
(0)

C7 shRNA Plasmid (h)

sc-91855-SHhGene SilencingPuromycin0
(0)

C7 shRNA (h) Lentiviral Particles

sc-91855-VhGene SilencingPuromycin0
(0)

C8α siRNA (h)

sc-88706hGene SilencingN/A0
(0)

C8α shRNA Plasmid (h)

sc-88706-SHhGene SilencingPuromycin0
(0)

C8α shRNA (h) Lentiviral Particles

sc-88706-VhGene SilencingPuromycin0
(0)

C8α siRNA (m)

sc-141941mGene SilencingN/A0
(0)

C8α shRNA Plasmid (m)

sc-141941-SHmGene SilencingPuromycin0
(0)

C8α shRNA (m) Lentiviral Particles

sc-141941-VmGene SilencingPuromycin0
(0)

C8β siRNA (h)

sc-88726hGene SilencingN/A0
(0)

C8β shRNA Plasmid (h)

sc-88726-SHhGene SilencingPuromycin0
(0)

C8β shRNA (h) Lentiviral Particles

sc-88726-VhGene SilencingPuromycin0
(0)

C8β siRNA (m)

sc-141942mGene SilencingN/A0
(0)

C8β shRNA Plasmid (m)

sc-141942-SHmGene SilencingPuromycin0
(0)

C8β shRNA (m) Lentiviral Particles

sc-141942-VmGene SilencingPuromycin0
(0)

C8γ siRNA (h)

sc-92621hGene SilencingN/A0
(0)

C8γ shRNA Plasmid (h)

sc-92621-SHhGene SilencingPuromycin0
(0)

C8γ shRNA (h) Lentiviral Particles

sc-92621-VhGene SilencingPuromycin0
(0)

C8γ siRNA (m)

sc-141933mGene SilencingN/A0
(0)

C8γ shRNA Plasmid (m)

sc-141933-SHmGene SilencingPuromycin0
(0)

C8γ shRNA (m) Lentiviral Particles

sc-141933-VmGene SilencingPuromycin0
(0)

C5L2 siRNA (h)

sc-105165hGene SilencingN/A
3
(0)

C5L2 shRNA Plasmid (h)

sc-105165-SHhGene SilencingPuromycin
3
(0)

C5L2 shRNA (h) Lentiviral Particles

sc-105165-VhGene SilencingPuromycin
3
(0)

C5L2 siRNA (m)

sc-141918mGene SilencingN/A0
(0)

C5L2 shRNA Plasmid (m)

sc-141918-SHmGene SilencingPuromycin0
(0)

C5L2 shRNA (m) Lentiviral Particles

sc-141918-VmGene SilencingPuromycin0
(0)