C3aR Antibody (17): sc-53782

C3aR Antibody (17) is a mouse monoclonal IgG2b antibody that detects C3aR in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and flow cytometry (FCM). C3aR, or complement component 3a receptor, plays a crucial role in the immune response by mediating the effects of the anaphylatoxin C3a, which is released during complement activation. Anti-C3aR antibody (17) recognizes receptors primarily located on the surface of myeloid leukocytes, including activated B-lymphocytes and certain brain cells, where C3aR triggers proinflammatory responses essential for pathogen elimination. The binding of C3a to C3aR activates various intracellular signaling pathways, leading to cellular degranulation, smooth muscle contraction, and the release of cytokines, which are vital for orchestrating an effective immune response. C3aR undergoes rapid phosphorylation and internalization upon activation, a process that regulates signaling capacity and ensures appropriate modulation of inflammatory responses. C3aR′s influence on leukocyte activation and chemotaxis underscores its significance in both normal immune function and in the pathophysiology of conditions such as asthma and bacterial infections, making C3aR monoclonal antibody (17) an invaluable tool for researchers studying these processes.

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C3aR Antibody (17) References:

1. Complement C3aR Inactivation Attenuates Tau Pathology and Reverses an Immune Network Deregulated in Tauopathy Models and Alzheimer's Disease.  |  Litvinchuk, A., et al. 2018. Neuron. 100: 1337-1353.e5. PMID: 30415998
2. Microglia exacerbate white matter injury via complement C3/C3aR pathway after hypoperfusion.  |  Zhang, LY., et al. 2020. Theranostics. 10: 74-90. PMID: 31903107
3. The complement C3-C3aR pathway mediates microglia-astrocyte interaction following status epilepticus.  |  Wei, Y., et al. 2021. Glia. 69: 1155-1169. PMID: 33314324
4. C3aR plays both sides in regulating resistance to bacterial infections.  |  Corcoran, JA. and Napier, BA. 2022. PLoS Pathog. 18: e1010657. PMID: 35925892
5. Helicobacter pylori-derived outer membrane vesicles contribute to Alzheimer's disease pathogenesis via C3-C3aR signalling.  |  Xie, J., et al. 2023. J Extracell Vesicles. 12: e12306. PMID: 36792546
6. Cntnap4 partial deficiency exacerbates α-synuclein pathology through astrocyte-microglia C3-C3aR pathway.  |  Zhang, W., et al. 2023. Cell Death Dis. 14: 285. PMID: 37087484
7. Complement C3aR depletion reverses HIF-1α-induced metabolic impairment and enhances microglial response to Aβ pathology.  |  Gedam, M., et al. 2023. J Clin Invest. 133: PMID: 37317973
8. C3a/C3aR synergies with TGF-β to promote epithelial-mesenchymal transition of renal tubular epithelial cells via the activation of the NLRP3 inflammasome.  |  You, D., et al. 2023. J Transl Med. 21: 904. PMID: 38082306
9. C3aR-initiated signaling is a critical mechanism of podocyte injury in membranous nephropathy.  |  Zhang, Q., et al. 2024. JCI Insight. 9: PMID: 38227377
10. An NFAT1-C3a-C3aR Positive Feedback Loop in Tumor-Associated Macrophages Promotes a Glioma Stem Cell Malignant Phenotype.  |  Zhang, Y., et al. 2024. Cancer Immunol Res. 12: 363-376. PMID: 38289255

The preferred C3aR antibody is C3aR Antibody (D-12): sc-133172.