TREX-1 Inhibitors
TREX-1 inhibitors comprise a diverse array of chemicals that either directly or indirectly modulate the activity of the DNA exonuclease TREX-1. AG-490 indirectly influences TREX-1 through JAK/STAT pathway modulation, while BAY 11-7082 indirectly targets TREX-1 through NF-κB pathway inhibition. 5-Fluorouracil (5-FU) directly inhibits TREX-1 by disrupting DNA synthesis, particularly thymidylate synthase. VX-11e directly inhibits TREX-1 by targeting the DNA repair pathway, specifically inhibiting DNA-PK. ATRA indirectly influences TREX-1 through RAR/RXR pathway modulation, impacting downstream signaling cascades. Cytarabine directly inhibits TREX-1 by incorporating into DNA and disrupting the DNA repair process.
LY294002 indirectly influences TREX-1 through PI3K pathway modulation, while Cisplatin directly inhibits TREX-1 by inducing DNA damage. BMS-345541 indirectly targets TREX-1 through the NF-κB pathway, and SB203580 indirectly influences TREX-1 by modulating the p38 MAPK pathway. Trichostatin A indirectly influences TREX-1 through HDAC inhibition, impacting gene expression. Bafilomycin A1 indirectly influences TREX-1 by targeting the autophagy-lysosome pathway, modulating the degradation of cellular components. These inhibitors provide valuable tools for studying the intricate mechanisms of TREX-1 regulation, shedding light on its role in DNA integrity and implications in various cellular processes.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Tyrphostin B42 | 133550-30-8 | sc-3556 | 5 mg | $26.00 | 4 | |
Tyrphostin B42 (AG-490), a JAK2 inhibitor, indirectly influences TREX-1 by targeting the JAK/STAT pathway. By inhibiting JAK2, AG-490 modulates the downstream signaling cascades connected to TREX-1. This indirect modulation can result in altered expression or activity of TREX-1, categorizing AG-490 as an indirect inhibitor of TREX-1. | ||||||
BAY 11-7082 | 19542-67-7 | sc-200615B sc-200615 sc-200615A | 5 mg 10 mg 50 mg | $62.00 $85.00 $356.00 | 155 | |
BAY 11-7082 is an NF-κB inhibitor that indirectly influences TREX-1. By inhibiting NF-κB, BAY 11-7082 modulates the downstream signaling cascades connected to TREX-1. This indirect modulation can result in altered expression or activity of TREX-1, categorizing BAY 11-7082 as an indirect inhibitor of TREX-1. | ||||||
Fluorouracil | 51-21-8 | sc-29060 sc-29060A | 1 g 5 g | $37.00 $152.00 | 11 | |
5-Fluorouracil (5-FU), an antimetabolite, directly targets DNA synthesis. By inhibiting thymidylate synthase, 5-FU disrupts the DNA repair process involving TREX-1. This direct inhibition interferes with TREX-1's ability to regulate DNA integrity, classifying 5-FU as a direct inhibitor of TREX-1. | ||||||
VX-11e | 896720-20-0 | sc-507301 | 10 mg | $180.00 | ||
VX-11e is a DNA-PK inhibitor that directly targets the DNA repair pathway. By inhibiting DNA-PK, VX-11e disrupts the DNA repair process involving TREX-1. This direct inhibition interferes with TREX-1's ability to regulate DNA integrity, classifying VX-11e as a direct inhibitor of TREX-1. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
ATRA, a retinoid, indirectly influences TREX-1 by targeting the RAR/RXR pathway. By binding to RAR/RXR receptors, ATRA modulates the downstream signaling cascades connected to TREX-1. This indirect modulation can result in altered expression or activity of TREX-1, categorizing ATRA as an indirect inhibitor of TREX-1. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is a PI3-kinase inhibitor that indirectly influences TREX-1 by targeting the PI3K pathway. By inhibiting PI3-kinase, LY294002 modulates the downstream signaling cascades connected to TREX-1. This indirect modulation can result in altered expression or activity of TREX-1, categorizing LY294002 as an indirect inhibitor of TREX-1. | ||||||
Cisplatin | 15663-27-1 | sc-200896 sc-200896A | 100 mg 500 mg | $138.00 $380.00 | 101 | |
Cisplatin, a platinum-containing chemotherapeutic, directly targets DNA by forming DNA adducts. By inducing DNA damage, Cisplatin disrupts the DNA repair process involving TREX-1. This direct inhibition interferes with TREX-1's ability to regulate DNA integrity, classifying Cisplatin as a direct inhibitor of TREX-1. | ||||||
BMS-345541 | 445430-58-0 | sc-221741 | 1 mg | $312.00 | 1 | |
BMS-345541 is an IKK inhibitor that indirectly influences TREX-1 through the NF-κB pathway. By inhibiting IKK, BMS-345541 modulates the downstream signaling cascades connected to TREX-1. This indirect modulation can result in altered expression or activity of TREX-1, categorizing BMS-345541 as an indirect inhibitor of TREX-1. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
SB203580 is a p38 MAPK inhibitor that indirectly influences TREX-1. By inhibiting p38 MAPK, SB203580 modulates the downstream signaling cascades connected to TREX-1. This indirect modulation can result in altered expression or activity of TREX-1, categorizing SB203580 as an indirect inhibitor of TREX-1. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Trichostatin A, an HDAC inhibitor, indirectly influences TREX-1 through epigenetic regulation. By inhibiting HDAC, Trichostatin A modulates the expression of genes related to TREX-1. This indirect modulation can result in altered expression or activity of TREX-1, categorizing Trichostatin A as an indirect inhibitor of TREX-1. | ||||||