Molecular structure of VX-11e, CAS Number: 896720-20-0
VX-11e (CAS 896720-20-0)
CAS Number:
896720-20-0
Molecular Weight:
500.35
Molecular Formula:
C24H20Cl2FN5O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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VX-11e (CAS 896720-20-0) References
- Involvement of FAK-ERK2 signaling pathway in CKAP2-induced proliferation and motility in cervical carcinoma cell lines. | Guo, QS., et al. 2017. Sci Rep. 7: 2117. PMID: 28522860
- Isoform-selective activity-based profiling of ERK signaling. | Shin, M., et al. 2018. Chem Sci. 9: 2419-2431. PMID: 29732117
- Vx-11e protects against titanium-particle-induced osteolysis and osteoclastogenesis by supressing ERK activity. | Li, C., et al. 2019. Biochem Biophys Res Commun. 514: 1244-1250. PMID: 31109651
- Combination of ERK2 inhibitor VX-11e and voreloxin synergistically enhances anti-proliferative and pro-apoptotic effects in leukemia cells. | Jasek-Gajda, E., et al. 2019. Apoptosis. 24: 849-861. PMID: 31482470
- Combination of ERK2 and STAT3 Inhibitors Promotes Anticancer Effects on Acute Lymphoblastic Leukemia Cells. | Jasek-Gajda, E., et al. 2020. Cancer Genomics Proteomics. 17: 517-527. PMID: 32859630
- High WHSC1L1 Expression Reduces Survival Rates in Operated Breast Cancer Patients with Decreased CD8+ T Cells: Machine Learning Approach. | Kim, HS., et al. 2021. J Pers Med. 11: PMID: 34357103
- Blockage of Extracellular Signal-Regulated Kinase Exerts an Antitumor Effect via Regulating Energy Metabolism and Enhances the Efficacy of Autophagy Inhibitors by Regulating Transcription Factor EB Nuclear Translocation in Osteosarcoma. | Zhang, M., et al. 2021. Front Cell Dev Biol. 9: 650846. PMID: 34414176
- The T-type Calcium Channel Cav3.1 in Y79 Retinoblastoma Cells is Regulated by the Epidermal Growth Factor Receptor via the MAPK Signaling Pathway. | Banderali, U., et al. 2022. Curr Eye Res. 47: 426-435. PMID: 34674590
- VX-11e protects articular cartilage and subchondral bone in osteoarthritis by inhibiting the RIP1/RIP3/MLKL and MAPK signaling pathways. | Zhang, W., et al. 2022. Bioorg Chem. 120: 105632. PMID: 35074577
- Identification of cell type-specific correlations between ERK activity and cell viability upon treatment with ERK1/2 inhibitors. | Lebedev, TD., et al. 2022. J Biol Chem. 298: 102226. PMID: 35787369
Inhibitor of:
ASCC1, C030046E11Rik, C22orf32, C6orf106_D17Wsu92e, CASC1, CD300LD, Cldn27, Cypt2, D6Mm5e, D830030K20Rik, EG231736, EG434396, EG626456, ERK 1, ERK 2, ERK 5, FBXW22, Gα i-3, IDAS, LMO2, Ly6G6f, M13 Major Coat Protein, MAP3K3, MIS12, MLTK, NBR1, Olfr54, Olfr971, PAK4, Pericentrin 2, PHTF2, Rad17, Reptin 52, Rsk-4, Srb10, syntenin-1, TIP120A, TREX-1, USH3A, and ZMAT4.Activator of:
FAM128B, FRMD6, and MAP-1B.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
VX-11e, 10 mg | sc-507301 | 10 mg | $180.00 |