Molecular structure of Tyrphostin B42, CAS Number: 133550-30-8
Tyrphostin B42 (CAS 133550-30-8)
See product citations (4)
Application:
Tyrphostin B42 is a potent JAK2 inhibitor
CAS Number:
133550-30-8
Molecular Weight:
294.30
Molecular Formula:
C17H14N2O3
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Tyrphostin B42 is a tyrosine kinase inhibitor of JAK2, EGFR, and Neu that belongs to the family of tyrphostins. In acute lymphoblastic leukemia studies the compound has been reported to inhibit JAK2 from B cell precursors. Additionally, Tyrphostin B42 has been observed to block cytokine-induced activation of JAK2 in eosinophils and STAT3 activation in T cell lymphoma cells. Unlike other kinase inhibitors, Tyrphostin B42 does not inhibit JAK1, Lck, Btk, Tyk2, Syk, Lyn, and Src. Research indicates that Tyrphostin B42 inhibits IL-7 mediated proliferation. Inhibition of Jak kinase activity by Tyrphostin B42 leads to lower levels of p85 phosphorylation and p-13 kinase activation.
Tyrphostin B42 (CAS 133550-30-8) References
- Tyrphostin B42 inhibits IL-12-induced tyrosine phosphorylation and activation of Janus kinase-2 and prevents experimental allergic encephalomyelitis. | Bright, JJ., et al. 1999. J Immunol. 162: 6255-62. PMID: 10229872
- Cardiotoxicity of de Gramont's regimen: incidence, clinical characteristics and long-term follow-up. | Meydan, N., et al. 2005. Jpn J Clin Oncol. 35: 265-70. PMID: 15855175
- The tyrphostin B42 inhibits cell proliferation and HER-2 autophosphorylation in cervical carcinoma cell lines. | Soto-Cruz, I., et al. 2008. Cancer Invest. 26: 136-44. PMID: 18259943
- Antiapoptotic properties of erythropoiesis-stimulating proteins in models of cisplatin-induced acute kidney injury. | Salahudeen, AK., et al. 2008. Am J Physiol Renal Physiol. 294: F1354-65. PMID: 18385271
- [Diagnostic and prognostic significance of anti-HBCAG IgM in hepatitis B and its outcomes]. | Fedorchenko, SV. 1991. Klin Med (Mosk). 69: 66-8. PMID: 1865655
- Tyrphostins I: synthesis and biological activity of protein tyrosine kinase inhibitors. | Gazit, A., et al. 1989. J Med Chem. 32: 2344-52. PMID: 2552117
- Tyrphostin B42 attenuates trichostatin A-mediated resistance in pancreatic cancer cells by antagonizing IL-6/JAK2/STAT3 signaling. | Zhang, X., et al. 2018. Oncol Rep. 39: 1892-1900. PMID: 29393444
- Activation of phosphatidylinositol-3 kinase by ligation of the interleukin-7 receptor is dependent on protein tyrosine kinase activity. | Dadi, H., et al. 1994. Blood. 84: 1579-86. PMID: 7520779
- JAK3 protein tyrosine kinase mediates interleukin-7-induced activation of phosphatidylinositol-3' kinase. | Sharfe, N., et al. 1995. Blood. 86: 2077-85. PMID: 7662955
- Inhibition of acute lymphoblastic leukaemia by a Jak-2 inhibitor. | Meydan, N., et al. 1996. Nature. 379: 645-8. PMID: 8628398
Inhibitor of:
β-sarcoglycan, 1700022P22Rik, 1700029I01Rik, 2010305A19Rik, ACTA2, AI428936, AMIGO1, AMIGO2, AMMECR1, Ang-1, ANKTM1, Arp-T1, BAI-2, BC002230, BC052484, BC055107, BC1D14, betaKlotho, Bex2, Bpifa6, BSMAP, C/EBP ε, C11orf65, C17orf63, C19orf47, C1orf177, C1QTNF (C1q and TNF related), C230057M02Rik, C230097I24Rik, C3orf34_1500031L02Rik, C5orf45, C9orf64, Cactin, CAGE, calmin, CCDC126, CCDC155, CDKL5, CEACAM1, Cldn27, CNTF, CNTNAP3, COL20A1, CRLF1, cryptdin 17, CTRP6, Cypt3, Cypt4, Cypt6, D530049N12Rik, D630037F22Rik, Dab1, DCI, DCST1, Deltex-3, Dppa1, Draxin, DRP2, DUB1A, DUB2, DUB2A, E130120F12Rik, EAT-2B, EG229879, EG243866, EG625424, EGFR, Endoglycan, EPCR, Exo1, FAM181B, FAM208A, FLJ39639, GalNAc-T7, GCP-2, GFRα-4, GFRαL, gp130, GRB14, GRB7, GRXCR2, H60a, HCF1, HEG1, HePTP, HIP-55, HIPK2, HNF-3β, HNF-3γ, HOP-1, HOXA3, HRASLS3, IFN-α1, IFN-α8, IFN-δ, IFN-γ, IFN-γRα, IL-17RA, IL-27Rα, IL-29, IL-3R, IL-3Rα, IL-6Rα, IL-7, IRS-3, ISG43, JAK2, JAM-C, JAM4, K12, KCP3, Keratocan, KIAA1683, KIAA1731, KLRG1, KNDC1, KRTAP4-5, KSHV K8α, LAT, LEPROT, LIF, LIFR, LILRC1, LMO2, LMO4, LOC100041377, LOC388279, LOC644070, LOC728504, LOC728734, LRIG1, LRRC54, LYPD4, LZP, Makorin-3, MIST1, Mx2, MYH7B, NCOAT, Neu, NF-1C, NKTR, NOR-1, nov, NXNL2, NYD-SP21, OC-STAMP, Odf4, Olfr484, Olfr510, Olfr512, Olfr513, Olfr514, Olfr516, Olfr517, Olfr538, Olfr553, Olfr691, Olfr692, Olfr693, Olfr694, Olfr697, Olfr698, Olfr699, Olfr700, Olfr843, Olfr876, Olfr877, Olfr878, Olfr90, Olfr908, Olfr909, Olfr91, Olfr910, Olfr912, Olfr913, Olfr914, Olfr915, Olfr916, Olfr917, Olfr918, Olfr919, Olfr92, Olfr921, Olfr922, Olfr974, Olfr975, Olfr993, Olfr994, Olfr995, Olfr996, Olfr998, ORMDL3, Otolin-1, OTTMUSG00000007521, OTTMUSG00000007655, OTTMUSG00000011269, OTTMUSG00000011270, OTTMUSG00000011272, OTTMUSG00000011273, OTTMUSG00000011275, OTTMUSG00000011285, OTTMUSG00000011289, OTTMUSG00000016780, PB1, PC-PLD2, PC-PLD4, PDAP1, PDLIM5, Pellino 1, Pira11, Pirb, Pitx1, plakophilin 1, Podocan, PTD015, PTH/PTHrP-R, QIP1, QKI, Reg IIIγ, RESP18, RIBC1, S-100A10, SARP3, SCA11, SCARA3, SH2-B, SH2D (SH2 domain containing protein), SIM1, SOCS-1, SOCS-4, SOCS-6, SSB-3, SSH2, Stat, Stat1, Stat3, STC2, Suppressor of Hairless, T1R2, TAGAP1, TESK1, THAP10, THSD3, TIPUH1, TMC5, TMEM134, TMEM43, TNK1, TNRC6B, TREX-1, TSARG1, TSLPR, UL16 binding protein (ULBP), ULBP2, USH3A, V1RE10, V1RH14, V1RH8, VIPL, Vmn1r12, WDR87, WFDC1A, ZC3H12D, and ZNF347.Activator of:
ADAM15, APS, Artn, BC053393, BCA3, BCAM, C16orf72, C2CD4A, C330019L16Rik, CD79B, CIS, Fer, GTPBP9, HHV-8 K14, HoxA1, IL-3Rβ, Integrin αX, JAK1, karyopherin α, KIR2DS4, Nek5, Ob-R, PLP-L, POU3F3 (Brn-1), Rak, SOCS-3, Sprouty 4, SR-5A, syntenin-1, THAP9, Tom1, and ZNF585A.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Tyrphostin B42, 5 mg | sc-3556 | 5 mg | $26.00 |