Tom22 Inhibitors
Tom22 inhibitors represent a collection of chemicals that, while not directly interacting with Tom22, have the potential to modulate its activity through various indirect mechanisms. Mdivi-1, an inhibitor of the mitochondrial fission protein Drp1, indirectly influences Tom22 by impacting mitochondrial dynamics, which can affect the import of proteins into mitochondria. CCCP, a mitochondrial uncoupler, indirectly influences Tom22 by dissipating the mitochondrial membrane potential, impacting overall mitochondrial function and protein transport. Similarly, CsA (Cyclosporin A), an immunosuppressive drug, indirectly affects Tom22 by inhibiting the opening of the mitochondrial permeability transition pore (mPTP), influencing mitochondrial function and protein import. Ru360, a specific inhibitor of the mitochondrial calcium uniporter (MCU), indirectly modulates Tom22 by influencing mitochondrial calcium levels, impacting mitochondrial processes and protein transport. TSA (Trichostatin A), a histone deacetylase (HDAC) inhibitor, indirectly affects Tom22 by modulating acetylation processes, influencing mitochondrial function and protein import.
Rapamycin, an mTOR inhibitor, serves as a potential indirect Tom22 inhibitor by modulating the mTOR signaling pathway, affecting mitochondrial processes and protein import. BAPTA-AM, a calcium chelator, indirectly influences Tom22 by chelating calcium, impacting mitochondrial calcium levels and protein transport. FCCP, another mitochondrial uncoupler similar to CCCP, indirectly affects Tom22 by disrupting the mitochondrial membrane potential and influencing mitochondrial dynamics. A769662, an AMP-activated protein kinase (AMPK) activator, indirectly modulates Tom22 by activating AMPK, impacting cellular energy status and mitochondrial function. Salinomycin, an antibiotic with anti-cancer properties, indirectly influences Tom22 by affecting mitochondrial function and potentially disrupting the mitochondrial membrane potential. In summary, these Tom22 inhibitors offer a diverse array of compounds that, through their indirect mechanisms, have the potential to modulate Tom22 activity, providing valuable tools for understanding mitochondrial dynamics and protein transport processes.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Mdivi-1 | 338967-87-6 | sc-215291 sc-215291B sc-215291A sc-215291C | 5 mg 10 mg 25 mg 50 mg | $67.00 $126.00 $251.00 $465.00 | 13 | |
Mdivi-1 is an inhibitor of the mitochondrial fission protein Drp1. While not directly targeting Tom22, its impact on mitochondrial dynamics may influence Tom22 function indirectly by affecting mitochondrial morphology and protein transport. | ||||||
Carbonyl Cyanide m-Chlorophenylhydrazone | 555-60-2 | sc-202984A sc-202984 sc-202984B | 100 mg 250 mg 500 mg | $77.00 $153.00 $240.00 | 8 | |
CCCP is a mitochondrial uncoupler that dissipates the mitochondrial membrane potential. Indirectly, it may influence Tom22 by affecting the overall mitochondrial environment and membrane potential, impacting the import of proteins into mitochondria. | ||||||
Cyclosporin A | 59865-13-3 | sc-3503 sc-3503-CW sc-3503A sc-3503B sc-3503C sc-3503D | 100 mg 100 mg 500 mg 10 g 25 g 100 g | $63.00 $92.00 $250.00 $485.00 $1035.00 $2141.00 | 69 | |
Cyclosporin A is an immunosuppressive drug that binds to cyclophilin D and inhibits the opening of the mitochondrial permeability transition pore (mPTP). While not a direct Tom22 inhibitor, its impact on mPTP may affect mitochondrial function and protein transport, influencing Tom22 indirectly. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Trichostatin A is a histone deacetylase (HDAC) inhibitor. While not directly targeting Tom22, its impact on acetylation processes within the cell may influence mitochondrial function and protein transport, indirectly affecting Tom22 activity. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin is an mTOR inhibitor. As a potential indirect inhibitor of Tom22, it may modulate the mTOR signaling pathway, influencing mitochondrial processes and protein import into mitochondria, impacting Tom22-associated functions. | ||||||
BAPTA/AM | 126150-97-8 | sc-202488 sc-202488A | 25 mg 100 mg | $138.00 $458.00 | 61 | |
BAPTA-AM is a cell-permeable calcium chelator. While not directly inhibiting Tom22, its ability to chelate calcium may impact mitochondrial calcium levels, indirectly influencing Tom22 function by affecting mitochondrial processes and protein transport. | ||||||
FCCP | 370-86-5 | sc-203578 sc-203578A | 10 mg 50 mg | $94.00 $355.00 | 46 | |
FCCP is a mitochondrial uncoupler similar to CCCP. Indirectly, it may affect Tom22 by disrupting the mitochondrial membrane potential and influencing mitochondrial dynamics, impacting the import of proteins into mitochondria. | ||||||
A-769662 | 844499-71-4 | sc-203790 sc-203790A sc-203790B sc-203790C sc-203790D | 10 mg 50 mg 100 mg 500 mg 1 g | $184.00 $741.00 $1076.00 $3417.00 $5304.00 | 23 | |
A769662 is an AMP-activated protein kinase (AMPK) activator. While not directly inhibiting Tom22, its activation of AMPK may influence cellular energy status and mitochondrial function, indirectly impacting Tom22-associated processes and protein transport into mitochondria. | ||||||
Salinomycin | 53003-10-4 | sc-253530 sc-253530C sc-253530A sc-253530B | 5 mg 10 mg 25 mg 100 mg | $162.00 $241.00 $406.00 $474.00 | 1 | |
Salinomycin is an antibiotic with anti-cancer properties. While not directly inhibiting Tom22, its impact on mitochondrial function and potential disruption of mitochondrial membrane potential may indirectly affect Tom22-associated processes and protein import into mitochondria. | ||||||
BML-275 | 866405-64-3 | sc-200689 sc-200689A | 5 mg 25 mg | $96.00 $355.00 | 69 | |
BML-275 (Compound C) is an AMP-activated protein kinase (AMPK) inhibitor. As a potential indirect inhibitor of Tom22, it may influence cellular energy status and mitochondrial function, impacting Tom22-associated processes and protein transport into mitochondria. | ||||||