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Cyclosporin A (CAS 59865-13-3)

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Alternate Names:
Cyclosporin A is also known as CsA.
Application:
Cyclosporin A is a fungal metabolite calcineurin and mitochondrial permeability transition pore opening inhibitor.
CAS Number:
59865-13-3
Purity:
≥98%
Molecular Weight:
1202.60
Molecular Formula:
C62H111N11O12
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Cyclosporin A (CsA) is a metabolite of the fungi Tolypocladium inflatum and a cyclic polypeptide consisting of 9 amino-acids to inhibit nitric oxide synthesis induced by interleukin 1alpha, lipopolysaccharides and TNFα. Studies in animals indicate that Cyclosporin A inhibits the development of cell-mediated reactions, including allograft immunity, delayed cutaneous hypersensitivity, experimental allergic encephalomyelitis, Freund′s adjuvant arthritis, graft-versus-host disease and also T-cell dependent antibody production. Cyclosporin A also inhibits lymphokine production and release and appears to block resting lymphocytes in the G0 or G1 phase of the cell cycle. Cyclosporin A binds to cyclophilin and inhibits the T-cell receptor signal transduction pathway via the formation of Cyclosporin A-cyclophilin complex. The CsA-cyclophilin complex inhibits calcineurin, a type 2B phosphatase. Furthermore, Cyclosporin A inhibits mitochondrial permeability transition pore opening, staurosporin-induced apoptosis in cultured neural cells, and rotenone-induced apoptosis in PC-12 cells.


Cyclosporin A (CAS 59865-13-3) References

  1. Cyclosporine for SJS/TEN: a case series and review of the literature.  |  Reese, D., et al. 2011. Cutis. 87: 24-9. PMID: 21323097
  2. Colon salvage therapy for acute severe colitis: cyclosporine or infliximab?  |  Burger, DC. and Travis, S. 2011. Curr Opin Gastroenterol. 27: 358-62. PMID: 21423006
  3. Acute severe colitis: infliximab and/or cyclosporine?  |  Fabro, M., et al. 2011. Curr Drug Targets. 12: 1448-53. PMID: 21466485
  4. Cyclosporine monotherapy in cardiac transplantation: review of the literature.  |  Sansone, F. and Rinaldi, M. 2011. Transplant Rev (Orlando). 25: 131-5. PMID: 21514135
  5. Mechanisms of renal cell apoptosis induced by cyclosporine A: a systematic review of in vitro studies.  |  Xiao, Z., et al. 2011. Am J Nephrol. 33: 558-66. PMID: 21613783
  6. [Treatment of rheumatic diseases: current status and future prospective. Topics: II. Immunosuppressant/antirheumatic drugs; 7. Cyclosporine].  |  Yamaji, K. 2011. Nihon Naika Gakkai Zasshi. 100: 2942-7. PMID: 22175135
  7. Cyclosporine in transplantation - a history of converging timelines.  |  Colombo, D. and Ammirati, E. 2011. J Biol Regul Homeost Agents. 25: 493-504. PMID: 22217983
  8. MG-160. A novel sialoglycoprotein of the medial cisternae of the Golgi apparatus [published eeratum appears in J Biol Chem 1989 Mar 5;264(7):4264].  |  Gonatas, JO., et al. 1989. J Biol Chem. 264: 646-53. PMID: 2909545
  9. Mitochondria-targeted cyclosporin A delivery system to treat myocardial ischemia reperfusion injury of rats.  |  Zhang, CX., et al. 2019. J Nanobiotechnology. 17: 18. PMID: 30683110
  10. FK506 and ciclosporin: molecular probes for studying intracellular signal transduction.  |  Liu, J. 1993. Trends Pharmacol Sci. 14: 182-8. PMID: 7692652
  11. Cyclosporin A, FK506 and rapamycin: more than just immunosuppression.  |  Kunz, J. and Hall, MN. 1993. Trends Biochem Sci. 18: 334-8. PMID: 7694398
  12. Modulation of the mitochondrial cyclosporin A-sensitive permeability transition pore. I. Evidence for two separate Me2+ binding sites with opposing effects on the pore open probability.  |  Bernardi, P., et al. 1993. J Biol Chem. 268: 1005-10. PMID: 8419309
  13. Inhibition of the mitochondrial permeability transition by cyclosporin A during long time frame experiments: relationship between pore opening and the activity of mitochondrial phospholipases.  |  Broekemeier, KM. and Pfeiffer, DR. 1995. Biochemistry. 34: 16440-9. PMID: 8845372
  14. Cyclosporin inhibition of apoptosis induced by mitochondrial complex I toxins.  |  Seaton, TA., et al. 1998. Brain Res. 809: 12-7. PMID: 9795106
  15. Pivotal role of mitochondrial calcium uptake in neural cell apoptosis and necrosis.  |  Kruman, II. and Mattson, MP. 1999. J Neurochem. 72: 529-40. PMID: 9930724

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Cyclosporin A, 100 mg

sc-3503
100 mg
$63.00

Cyclosporin A, 100 mg

sc-3503-CW
100 mg
$92.00

Cyclosporin A, 500 mg

sc-3503A
500 mg
$250.00

Cyclosporin A, 10 g

sc-3503B
10 g
$485.00

Cyclosporin A, 25 g

sc-3503C
25 g
$1035.00

Cyclosporin A, 100 g

sc-3503D
100 g
$2141.00

How long cyclosporin is active in cell medium?

Asked by: lara91
Thank you for your question. The time sc-3503 (Cyclosporin A) stays active in cell medium has not been tested, however, there are a lot of published journal articles that reference this chemical. Cyclosporin A has been proven to be active for 18h in cultured rat hepatocytes in the following article. https://www.ncbi.nlm.nih.gov/pubmed/3183963
Answered by: Technical Support
Date published: 2017-08-03

What is the appearance of the compound?

Asked by: two2igm05
This chemical, Cyclosporin A (CAS 59865-13-3), is a powder.
Answered by: Chemical Support 1
Date published: 2017-03-24

Is this product natural or synthetic? If natural, what does it come from?

Asked by: two2igm05
Thank you for your question. The compound, sc-3503, is a synthetic compound. If you have any further questions or concerns, please feel free to contact our Technical Service department by calling 800-457-3801 option 2, emailing scbt@scbt.com, or using the Live Chat function on our website.
Answered by: Tech Service 8
Date published: 2017-01-20

What is the solubility of this chemical?

Asked by: two2igm05
Thank you for your question. This chemical is soluble in acetone and chloroform at 6 mg/ml, DMSO and ethanol at 35 mg/ml, and methanol, ether, and petroleum ether at 10 mg/ml. It is insoluble in water. Please contact Technical Service if you have further questions concerning this product.
Answered by: Tech Service 9
Date published: 2016-12-15
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Rated 5 out of 5 by from Best Source for all of your research needs!Santa Cruz Biotechnology makes the checkout process hassle free and had exactly what I needed for my research needs! I am thankful for their top quality service and wide selection of products! I recommend Santa Cruz Biotechnology above all other similar companies!
Date published: 2021-07-30
Rated 5 out of 5 by from works as expectedworks as expected
Date published: 2015-11-19
Rated 5 out of 5 by from Farrow etFarrow et. al. used cyclosporin A, product sc-3503, to confirm the significance of A3G regulation by the binding of NFAT and IRF-4 to the A3G promoter. Cyclosporin A directly inhibits calcineurin, thus inhibiting NFAT nuclear translocation (PubMed ID 21078663). -SCBT Publication Review
Date published: 2015-04-11
Rated 5 out of 5 by from The cyclosporin seems to be workingThe cyclosporin seems to be working, we haven't done any quantification so can't say for sure.
Date published: 2015-03-30
Rated 5 out of 5 by from No commentNo comment
Date published: 2015-03-25
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Cyclosporin A is rated 5.0 out of 5 by 5.
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