Molecular structure of Salinomycin, CAS Number: 53003-10-4
Salinomycin (CAS 53003-10-4)
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Alternate Names:
Salinomycin is also known as Antibiotic 61477.
Application:
Salinomycin is a coccidiostat and carboxylic polyether potassium ionophore with antibiotic and anti-cancer properties.
CAS Number:
53003-10-4
Purity:
≥95%
Molecular Weight:
751.00
Molecular Formula:
C42H70O11
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Salinomycin is a polyether potassium ionophore antibiotic. Salinomycin promotes cation movement across biological membranes via exchange-diffusion. As a result of the cation exchange via Salinomycin, the transmembrane gradients are altered, which leads to changes in cellular function and metabolism. In addition, Salinomycin acts as a chelating agent towards monovalent cations such as sodium and potassium ions. Alternate studies suggest that Salinomycin selectively inhibits cancer stem-like cells.
Salinomycin (CAS 53003-10-4) References
- Effects of salinomycin on cancer stem cell in human lung adenocarcinoma A549 cells. | Wang, Y. 2011. Med Chem. 7: 106-11. PMID: 21222617
- Salinomycin selectively targets 'CD133+' cell subpopulations and decreases malignant traits in colorectal cancer lines. | Dong, TT., et al. 2011. Ann Surg Oncol. 18: 1797-804. PMID: 21267784
- Monitoring of autophagy is complicated--salinomycin as an example. | Jangamreddy, JR., et al. 2015. Biochim Biophys Acta. 1853: 604-10. PMID: 25541282
- Salinomycin radiosensitizes human nasopharyngeal carcinoma cell line CNE-2 to radiation. | Zhang, Y., et al. 2016. Tumour Biol. 37: 305-11. PMID: 26209294
- Inhibition of Autophagy Promotes Salinomycin-Induced Apoptosis via Reactive Oxygen Species-Mediated PI3K/AKT/mTOR and ERK/p38 MAPK-Dependent Signaling in Human Prostate Cancer Cells. | Kim, KY., et al. 2017. Int J Mol Sci. 18: PMID: 28524116
- Salinomycin-loaded Nanofibers for Glioblastoma Therapy. | Norouzi, M., et al. 2018. Sci Rep. 8: 9377. PMID: 29925966
- Salinomycin ameliorates oxidative hepatic damage through AMP-activated protein kinase, facilitating autophagy. | Kim, KY., et al. 2018. Toxicol Appl Pharmacol. 360: 141-149. PMID: 30290169
- Salinomycin: Anti-tumor activity in a pre-clinical colorectal cancer model. | Klose, J., et al. 2019. PLoS One. 14: e0211916. PMID: 30763370
- Salinomycin triggers endoplasmic reticulum stress through ATP2A3 upregulation in PC-3 cells. | Zhang, Y., et al. 2019. BMC Cancer. 19: 381. PMID: 31023247
- Salinomycin exerts anti-colorectal cancer activity by targeting the β-catenin/T-cell factor complex. | Wang, Z., et al. 2019. Br J Pharmacol. 176: 3390-3406. PMID: 31236922
- Salinomycin Suppresses Tumorigenicity of Liver Cancer Stem Cells and Wnt/Beta-catenin Signaling. | Liu, Q., et al. 2021. Curr Stem Cell Res Ther. 16: 630-637. PMID: 31971116
- Salinomycin Modulates the Expression of mRNAs and miRNAs Related to Stemness in Endometrial Cancer. | Talkowski, K., et al. 2021. Curr Pharm Biotechnol. 22: 317-326. PMID: 32564748
- Salinomycin mediated therapeutic targeting of circulating stem like cell population in oral cancer. | Patel, S., et al. 2022. J Biomol Struct Dyn. 40: 11141-11153. PMID: 34308783
- Salinomycin alleviates osteoarthritis progression via inhibiting Wnt/β-catenin signaling. | Chen, J., et al. 2022. Int Immunopharmacol. 112: 109225. PMID: 36095950
- Salinomycin-Loaded High-Density Lipoprotein Exerts Promising Anti-Ovarian Cancer Effects by Inhibiting Epithelial-Mesenchymal Transition. | Zou, M., et al. 2022. Int J Nanomedicine. 17: 4059-4071. PMID: 36105618
Inhibitor of:
α-actinin-2, β-TrCP, 2610208M17Rik, ALX3, ARMC5, Bcl-9L, Brn-2, CD133, Chibby 3, claudin-3, CRIF1, Cytokeratin 5, FAM123A, Gas2, GPR177, HE4, ICAT, Kremen-1, LGR5, LOC257407, LOC388963, LRP6, LRRFIP1, Oct-3/4, Oval Cell Marker, pan-Cytokeratin, PCID2, Prominin 2, Pygopus 1, R-Spondin2, SATB1, SIP1, SNAI 1, Soggy-1, SOSTDC1, Sox-2, Sox-21, Sox-22, TCF-1, TMEM9, Tom22, Tom70, USF-1, WISP-2, WNT (Wingless Int-1), Wnt-1, Wnt-15, Wnt-2, Wnt-5b, Wnt-7a, and ZNRF3.Activator of:
ATP6L, C030017K20Rik, Ferroportin-1, golgin 97, RNF43, STI1, and VDAC2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Salinomycin, 5 mg | sc-253530 | 5 mg | $159.00 | |||
Salinomycin, 10 mg | sc-253530C | 10 mg | $236.00 | |||
Salinomycin, 25 mg | sc-253530A | 25 mg | $398.00 | |||
Salinomycin, 100 mg | sc-253530B | 100 mg | $465.00 |