Molecular structure of BAPTA/AM, CAS Number: 126150-97-8
BAPTA/AM (CAS 126150-97-8)
See product citations (61)
Alternate Names:
BAPTA/AM is also known as BAPTA Acetoxymethyl ester.
Application:
BAPTA/AM is a membrane-permeable, selective, Ca2+-chelating analog of BAPTA that has antithrombotic activity in vitro.
CAS Number:
126150-97-8
Molecular Weight:
764.68
Molecular Formula:
C34H40N2O18
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
BAPTA/AM [1,2-Bis(2-aminophenoxy)ethane-N,N,N′,N′-tetraacetic acid tetrakis(acetoxymethyl ester)] is a non-fluorescent, membrane-permeable form of BAPTA. Whereas the BAPTA, Free acid (sc-201508) is not cell permeable and is only useful for manipulating extracellular Ca2+ levels, BAPTA/AM can be used with a wide variety of cells, where it is hydrolyzed by cytosolic esterases and trapped intracellularly. Experiments have shown that BAPTA/AM abolishes vitamin D3-induced increase in intracellular Ca2+, and may induce inactivation of protein kinase C. BAPTA/AM has also been shown to inhibit thapsigargin-induced apoptosis in rat thymocytes. BAPTA/AM is a high quality and sensitive compound for calcium signaling studies, investigation of signal transduction and apoptotic cascades, and neuroscience research. Additional BAPTA chelators available: BAPTA, Free Acid (sc-201508) BAPTA tetrapotassium salt (sc-202076) BAPTA-APM (sc-206966) BAPTA-TMFM (sc-212043) 5,5i difluoro Bapta(AM) (sc-217247) 5,5i difluoro Bapta(K+ Salt) (sc-217248) Bapta-FF (AM) (sc-217696) BAPTA, Tetrasodium Salt (sc-278716)
BAPTA/AM (CAS 126150-97-8) References
- Elevation of resting mitochondrial membrane potential of neural cells by cyclosporin A, BAPTA-AM, and bcl-2. | Kowaltowski, AJ., et al. 2000. Am J Physiol Cell Physiol. 279: C852-9. PMID: 10942734
- BAPTA/AM, an intracellular calcium chelator, induces delayed necrosis by lipoxygenase-mediated free radicals in mouse cortical cultures. | Wie, MB., et al. 2001. Prog Neuropsychopharmacol Biol Psychiatry. 25: 1641-59. PMID: 11642660
- Loading neurons with BAPTA-AM activates xbp1 processing indicative of induction of endoplasmic reticulum stress. | Paschen, W., et al. 2003. Cell Calcium. 33: 83-9. PMID: 12531184
- BAPTA-AM, an intracellular calcium chelator, inhibits RANKL-induced bone marrow macrophages differentiation through MEK/ERK, p38 MAPK and Akt, but not JNK pathways. | Zhou, S., et al. 2010. Cytokine. 52: 210-4. PMID: 20667748
- Calcium ion regulation by BAPTA-AM and ruthenium red improved the fertilisation capacity and developmental ability of vitrified bovine oocytes. | Wang, N., et al. 2017. Sci Rep. 7: 10652. PMID: 28878377
- The effect of temperature and ionic strength on the apparent Ca-affinity of EGTA and the analogous Ca-chelators BAPTA and dibromo-BAPTA. | Harrison, SM. and Bers, DM. 1987. Biochim Biophys Acta. 925: 133-43. PMID: 3113491
- Mechanisms of arrhythmogenic delayed and early afterdepolarizations in ferret ventricular muscle. | Marban, E., et al. 1986. J Clin Invest. 78: 1185-92. PMID: 3771791
- New calcium indicators and buffers with high selectivity against magnesium and protons: design, synthesis, and properties of prototype structures. | Tsien, RY. 1980. Biochemistry. 19: 2396-404. PMID: 6770893
- A non-disruptive technique for loading calcium buffers and indicators into cells. | Tsien, RY. 1981. Nature. 290: 527-8. PMID: 7219539
- 1,25(OH)2 vitamin D3 activates PKC-alpha in Caco-2 cells: a mechanism to limit secosteroid-induced rise in [Ca2+]i. | Bissonnette, M., et al. 1994. Am J Physiol. 267: G465-75. PMID: 7943245
- Molecular cloning of TPAR1, a gene whose expression is repressed by the tumor promoter 12-O-tetradecanoylphorbol 13-acetate (TPA). | Jiang, W., et al. 1994. Exp Cell Res. 215: 284-93. PMID: 7982471
- Intracellular calcium chelator, BAPTA-AM, prevents cocaine-induced ventricular fibrillation. | Billman, GE. 1993. Am J Physiol. 265: H1529-35. PMID: 8238564
- BAPTA induces a decrease of intracellular free calcium and a translocation and inactivation of protein kinase C in macrophages. | Dieter, P., et al. 1993. Biol Chem Hoppe Seyler. 374: 171-4. PMID: 8387795
Inhibitor of:
β-defensin 46, 1700067K01Rik, 1700067P10Rik, 1700069P05Rik, 1700071A11Rik, 1700071K01Rik, 1700072E05Rik, 1700072O05Rik, 1700074I03Rik, 1700074P13Rik, 1700080E11Rik, 1700080G18Rik, 1700080N15Rik, 1700080O16Rik, 1700081L11Rik, 1700084C01Rik, 1700084D21Rik, 1700084E18Rik, 1700085B13Rik, 1700086D15Rik, 1700086L19Rik, 1700088E04Rik, 1700091H14Rik, 1700092M07Rik, 4922505G16Rik, 4930408G06Rik, 4931407G18Rik, 4933412E24Rik, 5730419I09Rik, adseverin, AHCYL2, ALG-2, ALS2CR11, AMIGO1, ANKRD25, ANKS3, Annexin A9, Annexin IV, Annexin VIII, APBA2BP, APR3, BC024139, BTBD3, Bu-1a, C11orf20, C14orf39, C15orf59, C16orf61, C16orf89, C17orf61, C17orf85, C1orf158_1700012P22Rik, C1orf163, C1orf174_A430005L14Rik, C1orf185, C1orf21, C1QTNF (C1q and TNF related), C2CD4D, C2orf55, C3orf30, C3orf33, C5orf30, C6orf105, C6orf203, C6orf211, C8β, C8orf31, CAB39L, CaBP1, CaBP7, cadherin-28, Calgizzarin, CALHM3, calsequestrin 1, calsyntenin-2, cAMP, CAPS2, CASPR3, CatSperγ2, CCDC17, CCDC23, CCDC24, CCDC49, CDH20, CDRT1, CGREF1, CHL1, CHP, CIB, claudin-2, Cntnap5c, copine 3, copine 7, copine 9, CPO, CRHSP-24, CRISP-2, CTRP2, CUTA, Cypher, Cypt15, DOC2A, DRIM, E230019M04Rik, EG667094, EG667472, EG667512, EG667599, EMR3, Enkurin, ERICH2, Fam148b, FAM161B, FAM166A, FAM181B, FAM188B2, FAM62B, FAM62C, FAM69A, FATE1, FER1L5, FHL-4, FLJ39779, FNDC3A, Galanin, GALP, Gcap14, Gm5849, Golgin 45, GPR128, GPR144, GPR155, GPR63, GPR89A, Grancalcin, GRIP2, Harmonin, HCC-4, HEATR4, HECA, HEPACAM2, HIP3, HIT-40, hnRNP UL2, HRASLS3, HS1BP3, ICA69, IGSF4C, Ik1, IP3KC, IQCE, ISLR2, ITFG2, ITPRIPL1, ITPRIPL2, JKTBP, Junctophilin-3, K-cadherin, KCP3, Keratocan, KRTAP7-1, Kua, lacritin, LAIR-2, Laminin β-2, Laminin-5, LEREPO4, LIN-2, Lingo-2, Lipocalin-14, LOC100041249, LOC100042603, LOC388284, LOC391356, LOC646960, LOC647194, LOC651033, LOC728085, LOC728261, LOC729928, LOC729966, LRFN3, LRFN4, LRRC20, LRRC21, LRRC28, LRRC37B, LRRC54, LRTM2, Lutropin β, LYPD3, LYPD6B, M6B, MAGI-1, MAWDBP, MCTP2, MDGA1, Mg29, MORN4, MORN5, MPP9, MRTF-B, MS4A4C, Mucin 20, MYH3, MYL10, myomesin-2, Myopodin, NE-dlg, NEPH3, Neudesin, NGL-1, NHLRC4, Nicalin, NPS, NrCAM, NRN1L, NTT4, nucleobindin, NUDT8, NYAP2, NYD-SP21, Olfr1051, Olfr1099, Olfr370, Olfr373, Olfr374, Olfr376, Olfr378, Olfr38, Olfr393, Olfr438, Olfr446, Olfr447, Olfr455, Olfr457, Olfr458, Olfr46, Olfr460, Olfr461, Olfr463, Olfr464, Olfr466, Olfr467, Olfr469, Olfr47, Olfr485, Olfr486, Olfr487, Olfr488, Olfr491, Olfr522, Olfr523, Olfr524, Olfr525, Olfr527, Olfr53, Olfr544, Olfr560, Olfr64, Olfr648, Olfr713, Olfr715, Olfr716, Olfr748, Olfr749, Olfr750, Olfr76, Olfr761, Olfr763, Olfr779, Olfr819, Olfr837, Olfr871, Olfr872, Olfr889, Olfr90, Olfr900, Olr22, Olr286, OR1J2, OR1L8, Otospiralin, OTTMUSG00000010136, p-Thr, PAP21, PAT3, PAWP, PCDHA8, PCDHB6, PCDHBPcdhb22, Pcdhgb8, PCNXL2, PCNXL3, PDI1 ER and Nuclear Envelope Marker, PDZ-GEF1, PDZK4, Pet2, PLAC8L1, Platelet receptor Gi24, PLEKHH2, PLEKHH3, PLEKHJ1, PLSCR1, PMCA3, PNMA5, Polycystin-1L3, promethin, Protamine 2, Protein S, PRRT1, QSER1, RASEF, RasGRP, RBJ, RBMX, Relaxin 2, reticulocalbin-3, S-100, S-100A2, S-100A3, S-100A5, S-100P, S-100Z, SAPCD2, SCAMP5, SCRN3, Secretoneurin, Sectm1b, SEMA7A, Skint2, Slfn12L, Slfn8, Slfn9, SNT-2, spectrin β II, spectrin β IV, SPEM1, SPINT4, SPNS3, Stomatin, striatin, Synaptotagmin IV, Synaptotagmin XV, syncytin, syncytin-2, syncytin-B, SYNPO2L, T2R5, TANC2, TAP26, TAPP2, Tas2r103, TBC1D28, Tescalcin, THA1P, TIGD7, Titin, TM9SF3, TMCO5, TMEM125, TMEM154, TMEM160, TMEM171, TMEM184B, TMEM185A, TMEM199, TMEM201, TMEM229B, TMEM24, TMEM66, Tom22, Troponin C, TSGA13, TSPAN8, TTYH2, UCH-L1, V1RA2, V1RB9, V1rc1, V1RC3, V1rc31, V1RD1, V1RD11, V1RG4, V1RG5, V1RH2, V1RH4, V1RI7, VILIP-2, VLP, Vmn1r114, Vmn1r116, Vmn1r118, Vmn1r126, Vmn1r129, Vmn1r149, Vmn1r158, Vmn1r159, Vmn1r161, Vmn1r169, Vmn1r20, Vmn1r224, Vmn1r31, Vmn1r60, Vmn2r10, Vmn2r102, Vmn2r11, Vmn2r114, Vmn2r116, Vmn2r18, Vmn2r66, Vmn2r72, Vmn2r8, Vmn2r85, Vmn2r86, Vmn2r87, Vmn2r9, Vmn2r98, WDR88, XKR5, XPR, Zap3, ZC3HDC3, ZFP101, ZPBP1, and ZUD_UNC5CL.Activator of:
1600002K03Rik, 1600021P15Rik, 1700001C02Rik, 1700008O03Rik, 1700008P02Rik, 1700022C21Rik, 2310066E14Rik, 3110001D03Rik, 3200002M19Rik, 4932418E24Rik, 5430413K10Rik, 5730419I09Rik, 5730508B09Rik, 5830403L16Rik, 5830411N06Rik, 6430537H07Rik, 9130409J20Rik, 9230107M04Rik, 9230110C19Rik, ABHD7, Abi-2, ACAP2, ACRC, ADAM33, AGP-3, AGPHD1, ALG2, Annexin VII, Bestrophin-1, BLOS1, BMP-1, BTN2A1, C11orf74, C130079G13Rik, C14orf1_0610007P14Rik, C15orf58, C17orf57, C17orf85, C330006A16Rik, C6orf65, Cactin, cadherin-18, CALHM2, CALM, calmodulin, Calpain 14, CALR3, Calretinin, calsyntenin-1, Calumenin, CaM V, CaMKIδ, CaMKIγ, CaMKV, CANT1, CAPSL, CASKIN1, CBARA1, CCDC109B, CCDC150, CCDC155, CDRT15, Centrin-4, CHERP, CIB, CIB2, CIN85, Cingulin, Clca6, CLRN2, CMV gH, copine 7, CRAMP1L, cryptdin 5, CT120, D630042P16Rik, DEPDC7, DPCR1, DREAM, EAT-2, EF-CAB3, EF-CAB7, EF-HC1, EG546488, EG624918, ELKS, FAM136A, FAM47A, FAM70A, FBXW2, FGF-16, Formin 1, Fsbp, GAAP, gasdermin A2, gasdermin C, GKAP, GKAP1, Gm12, Gm5849, GPR8, hole, HoxB9, IL-12Rβ2, IMPA3, IP3R-I, IP3R-III, IPMK, IQCC, IQCJ, ISLR, ITI-H3, ITPK1, Jaw1, JP-45, KCTD13, KIAA1683, KIR2DL3, KLHL38, LGICZ1, LOC644361, LOC645722, LOC646037, LOC85449, LRRC1, LRRC10B, LRRC44, LRRC55, LRRN2, LRRTM1, LRRTM4, Lsk_Ctk, LURAP1L, LYPD4, MA2, MAGIX, MASS1, MBLAC1, MEPE, MIER1, Mitsugumin23, MLEC, Moesin, MRS2L, Munc13-2, Munc13-3, NBEAL2, NCKX4, NCS-1, neurocalcin δ, NgR3, NKR-P1F, NKTR, NUDT6, OBSL1, Odf1, Olfr1055, Opalin, OR13C5, OR13D1, OR1G1, OR4D1, OR4D2, Otoferlin, Otolin-1, OTTMUSG00000019786, Pannexin-3, PCDHB4, PEF, PIPK I γ, plakophilin 4, PLC δ3, PLC γ2, PLCδ1, Pma2, PMCA4b, Pol III RPC62, PP2B-Aβ, PP2B-B1, Pre-TCRα, RasGRP4, RDC-1, RFX-B, RGD1560436, RIBC2, Rim3, RNF11, RY1, S-100A14, SBK1, SCaMC-1, SFXN3, Shigatoxin 2, Slac2-b, SPAG8, SPUVE, SSB-2, SVOP, Swiprosin-2, Synapsin IIa, Synaptogyrin-3, Synaptotagmin I/II, Synaptotagmin II, Synaptotagmin III, Synaptotagmin VI, Synaptotagmin VII, Synaptotagmin X, Synaptotagmin XI, Synaptotagmin XII, Synaptotagmin XIII, Synaptotagmin XV, Synaptotagmin XVII, Syne-3, Syntaxin 11, Syntaxin 19, T2R29, TCR δ, Tctex1, TECPR2, Themis, TMCC2, TMCO2, TMEM110, TMEM12, TMEM155, TMEM16E, TMEM16F, TMEM16H, TMEM174, TMEM178, TMEM202, TMEM22, TMEM225, TMEM231, TMEM32, TMEM38A, TMEM63B, TMEM69, TorsinA, TorsinB, Trim12c, Troponin I-FS, TRPC4AP, TRPC7, TTYH3, TyrRS, ULBP3, UNQ9438, v-SNARE Vti1a, V1RE10, V1RE11, V1RH14, VAP-A, Vmn1r118, Vmn1r128, Vmn2r19, Vmn2r20, Vmn2r21, Vmn2r22, VZV Major Capsid Protein, WDR18, WDR37, WDR49, WDR7, WDR87, ZC3H7A, ZCCHC18, ZCCHC9, ZDHHC1, ZNF239, ZNF518, and ZnT-4.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
BAPTA/AM, 25 mg | sc-202488 | 25 mg | $138.00 | |||
BAPTA/AM, 100 mg | sc-202488A | 100 mg | $449.00 |