Molecular structure of A-769662, CAS Number: 844499-71-4
A-769662 (CAS 844499-71-4)
See product citations (23)
Alternate Names:
A-769662 is known as a direct AMPK activator.
Application:
A-769662 is an AMPK activator which induces PI3-kinase-dependent glucose uptake and inhibits AMPK dephosphorylation.
CAS Number:
844499-71-4
Purity:
≥98%
Molecular Weight:
360.39
Molecular Formula:
C20H12N2O3S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
A-769662 is an AMP-activated protein kinase (AMPK) activator that mimics the function of AMP on AMPK β-1 by allosteric activation and the inhibition of dephosphorylation of AMPK. In the prescence of both LKB1 and A-769662, the phosphorylation of AMPK is suppressed. In addition, A-769662 is not effected by upstream kinases such as calmodulin-dependent protein kinase kinase-β when phosphorylating AMPK beta-1. In vitro tests indicate A-769662 suppresses the activity of Sodium-Potassium Adenosine Triphosphatase by inhibiting the α(1)-isoform of the pump and decreasing the cell surface abundance of the protein complex in skeletal muscle cells and induces glucose uptake through a PI3-kinase-dependent pathway.
A-769662 (CAS 844499-71-4) References
- Defining the mechanism of activation of AMP-activated protein kinase by the small molecule A-769662, a member of the thienopyridone family. | Sanders, MJ., et al. 2007. J Biol Chem. 282: 32539-48. PMID: 17728241
- Mechanism of action of A-769662, a valuable tool for activation of AMP-activated protein kinase. | Göransson, O., et al. 2007. J Biol Chem. 282: 32549-60. PMID: 17855357
- Inhibitory effects of A-769662, a novel activator of AMP-activated protein kinase, on 3T3-L1 adipogenesis. | Zhou, Y., et al. 2009. Biol Pharm Bull. 32: 993-8. PMID: 19483304
- A-769662 activates AMPK beta1-containing complexes but induces glucose uptake through a PI3-kinase-dependent pathway in mouse skeletal muscle. | Treebak, JT., et al. 2009. Am J Physiol Cell Physiol. 297: C1041-52. PMID: 19657063
- AMP-activated protein kinase activator A-769662 is an inhibitor of the Na(+)-K(+)-ATPase. | Benziane, B., et al. 2009. Am J Physiol Cell Physiol. 297: C1554-66. PMID: 19828836
- Escherichia coli expression, purification and characterization of functional full-length recombinant alpha2beta2gamma3 heterotrimeric complex of human AMP-activated protein kinase. | Rajamohan, F., et al. 2010. Protein Expr Purif. 73: 189-97. PMID: 20451617
- Small molecule drug A-769662 and AMP synergistically activate naive AMPK independent of upstream kinase signaling. | Scott, JW., et al. 2014. Chem Biol. 21: 619-27. PMID: 24746562
- A-769662 potentiates the effect of other AMP-activated protein kinase activators on cardiac glucose uptake. | Timmermans, AD., et al. 2014. Am J Physiol Heart Circ Physiol. 306: H1619-30. PMID: 24748590
- A-769662 protects osteoblasts from hydrogen dioxide-induced apoptosis through activating of AMP-activated protein kinase (AMPK). | Zhu, Y., et al. 2014. Int J Mol Sci. 15: 11190-203. PMID: 24960362
- AMPK Activation by A-769662 Controls IL-6 Expression in Inflammatory Arthritis. | Guma, M., et al. 2015. PLoS One. 10: e0140452. PMID: 26474486
- AMP-activated protein kinase (AMPK) activator A-769662 increases intracellular calcium and ATP release from astrocytes in an AMPK-independent manner. | Vlachaki Walker, JM., et al. 2017. Diabetes Obes Metab. 19: 997-1005. PMID: 28211632
- A-769662 inhibits adipocyte glucose uptake in an AMPK-independent manner. | Kopietz, F., et al. 2021. Biochem J. 478: 633-646. PMID: 33493298
- Increasing SnRK1 activity with the AMPK activator A-769662 accelerates seed germination in rice. | Hu, Y., et al. 2022. Plant Physiol Biochem. 185: 155-166. PMID: 35696890
Inhibitor of:
β-defensin 21, β-defensin 22, β-defensin 26, β-tectorin, 2900097C17Rik, 9130008F23Rik, ACCβ, ACOT9, AIP2, AMMECR1, AMPKβ2, AMPKγ1, ANKRD44, ATF-5, BC066028, BTG2, C030037F17Rik, C130074G19Rik, C19orf21, C20orf19, C22orf32, C230052I12Rik, C230072F16Rik, C2orf73, C2orf79, C330006A16Rik, C330006K01Rik, C330013F16Rik, C3orf43, C3orf72, C6orf183, C9orf69, CAGE, ChREBP, CILP-2, claudin-3, CRB3, D5Ertd577e, DHRS6, E130120F12Rik, EG270499, EG432838, EG436188, EG622744, EG627094, EG627352, Esp34, Esp36, Esp8, Extensin, FAM75A1, FNDC1, GP-39, IFFO2, KIAA1107, Klp3, KRI1, KRTAP25-1, Laminin α-4, LANCL1, LHPP, LRP2BP, LRRTM1, Mimp, MKS1, MO25, MrgA7, muscle FBPase, NBR1, NK homeobox (NKX), NP220, Nuak1, OCR1, Olfr477, Olfr48, Olfr480, Olfr553, Olfr584, Olfr586, Olfr589, Olfr59, Olfr591, Olfr592, Olfr594, Olfr804, Olfr830, Oma1, OTTMUSG00000012817, OTTMUSG00000016607, OTTMUSG00000016611, Podocin, Protein tyrosine phosphatase (PRL1, PRL2 ,PRL3) inhibitors, PTP22, Radixin, REDD-1, RPGRIP1L, SGTB, SIK2, syntenin-1, T1R2, TAP, Tom22, TREML6, UPLP, V5-Probe, and Zfp13.Activator of:
1700052N19Rik, 4930404A10Rik, 4932411N23Rik, ACOX1, ACTR-I, ADAM12, ADCK1, AFX1, AI462493, AK1, AK5, AMDHD1, AMPK, AMPKα1, AMPKγ3, Ang-1, ANKRD16, ANKRD50, ANT2, apoD, ARK-2, ARK5, ARMC5, ATPIF1, ATXN2L, Bag-3, BC030396, BC052486, BEND2, Bex6, Bob 1, BTG4, C/EBP α, C11orf74, C16orf61, C17orf63, C21orf59_1110004E09Rik, C2CD4A, C7orf50, C920016K16Rik, CAB39L, CALR4, CaMKIIγ, CaMKKα, CARD 12, CARP, cathepsin M, CCDC40, CCDC55, CCDC61, CD2, Cdk11, CENP-VL1, CGGBP1, citrate synthase, CMV pp65, CNOT8, CRIK, CRX, cryptdin 26, CT45-2, CTMP, CTRP3, Cypt3, Cypt6, D3Ertd254e, D6Mm5e, DDX41, DEC2, Dengue Virus, DEPDC7, DP58, DUB1, Dynlt3, EAAT5, Eapa2, EBV EBNA-3A, ECHDC3, EG231736, EG236749, EG330305, EG381582, EG382639, EG384585, EG432995, EG434729, EG434881, EG545802, EG546400, EG622744, EG624918, EG625591, EG627352, EG627821, Elongin A, EMBP, ENSA, ephrin-B1, ER81, Factor B, FADS2, FAIM2, FAS, FDXACB1, FGF-15, FHL-2, Fibulin-1, FNIP1, Fsbp, GABP-β2, Giantin, girdin, GITRL, Glut11, Gm6772, Grpa, HAPSTR2, HB9, HDA2, HNF-3γ, hnRNP F, hnRNP U, HS3ST2, HSV-1 gD, ICF45, IDE, IFN-δ, IGFBP4, KBP, KCC3, KCC4, KILLIN, KNDC1, Krox-26, LDHA, LDHB, LI-cadherin, LOC388284, LOC644070, LOC727954, LRRC57, MA1, MACROD2, Mad 1, Maestro, MARCO, MARVELD3, MAST3, MBNL1, MBP, MCT4, METTL21A, MFSD6, Mig-6, MP68, MRP-L47, MRS2L, MXL-1, Myelin P2, Myf-5, Myf-6, MYG1, myocilin, NAB2, NARC-1, NDRG2, NDRG3, NDUFA10, NFAT5, Nix, Nkx-2.5, NOL6, NPIP, NT-3, NTR3, Nur77, OAS1, OTTMUSG00000013284, OTTMUSG00000016789, OTTMUSG00000016790, p14 ARF/p16, P23, PDC-E2, Pdcd-1L1, PDGF-C, PDGF-D, PHKG1, PRAMEF8, PSPC1, PYGL, Rad21, Rheb, Ribosomal Protein L14, Rsk, SAGE1, SAP 14_SF3B14, SBNO2, SDSL, Serine racemase, SH3TC1, Shank 2, SIK1, SLTM, Sos 2, SPANX-N, SPNS2, ST2, STK40, STPG2, STRAD, SUCLA2, SUSD3, Synaptotagmin XIV, TAF II p250, Tap42, TBC1D1, TEF-3, TEX13A, TFIIE-β, THAP2, Thrombospondin 4, Tie-2, TIGD3, TIM-1, Tim10, Titin, TMEM156, TMEM170, TPR, Treslin, TRIML2, Trk A, TSSK 2, UKHC, VSTM1, WBP5, WDFY2, WDR34, WDR87, XTRP2, ZC3H12D, ZC3H7A, Zfp866, and ZNF642.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
A-769662, 10 mg | sc-203790 | 10 mg | $180.00 | |||
A-769662, 50 mg | sc-203790A | 50 mg | $726.00 | |||
A-769662, 100 mg | sc-203790B | 100 mg | $1055.00 | |||
A-769662, 500 mg | sc-203790C | 500 mg | $3350.00 | |||
A-769662, 1 g | sc-203790D | 1 g | $5200.00 |