TIN-Ag Inhibitors
Chemical inhibitors of TIN-Ag function by interfering with the protein's interaction with the extracellular matrix and related cellular processes. Marimastat is one such inhibitor, acting broadly against matrix metalloproteinases (MMPs) to hinder the remodeling activities that TIN-Ag may be involved in. Similarly, GM6001, or Ilomastat, functions as a potent inhibitor, targeting MMPs to stabilize the extracellular matrix, thus affecting the matrix-associated functionality of TIN-Ag. TAPI-0, which inhibits ADAM17, can affect TIN-Ag's role in proteolytic cleavage of membrane proteins, altering its function in cell-matrix interactions. SB-3CT, with its selectivity for inhibiting MMPs 2 and 9, reduces the degradation of the matrix that could be essential for TIN-Ag's role in tissue remodeling.
Further influencing TIN-Ag's interaction with the extracellular matrix, NSC 405020 specifically targets MMP-14, which is a key player in the degradation of the matrix and potentially affects TIN-Ag function. ARP 100, as a selective MMP-2 inhibitor, also contributes to the stabilization of the extracellular environment, influencing TIN-Ag's activity. Batimastat, another broad-spectrum MMP inhibitor, impacts the extracellular matrix remodeling, which is a process where TIN-Ag is thought to play a part. PD166793 extends this effect as a broad-spectrum inhibitor, further contributing to the stability of the matrix and, consequently, the functions of TIN-Ag. Ro 32-3555 and WAY-170523, targeting MMP-9 and MMP-13 respectively, contribute to the inhibition of the breakdown of matrix components, which can alter the functional landscape for TIN-Ag. Finally, Prinomastat, an MMP inhibitor, prevents the degradation of the matrix, thereby influencing TIN-Ag's role in cell-matrix interactions. Through the combined actions of these chemical inhibitors, the extracellular matrix is stabilized, which in turn affects the functionality of TIN-Ag in processes dependent on cell-matrix dynamics.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Marimastat | 154039-60-8 | sc-202223 sc-202223A sc-202223B sc-202223C sc-202223E | 5 mg 10 mg 25 mg 50 mg 400 mg | $168.00 $218.00 $404.00 $629.00 $4900.00 | 19 | |
Marimastat is a broad-spectrum matrix metalloproteinase inhibitor. TIN-Ag is implicated in cellular adhesion and extracellular matrix interactions. Marimastat can inhibit the remodeling of the extracellular matrix, which TIN-Ag may interact with, thus potentially leading to the functional inhibition of TIN-Ag's role in cell-matrix adhesion processes. | ||||||
GM 6001 | 142880-36-2 | sc-203979 sc-203979A | 1 mg 5 mg | $77.00 $270.00 | 55 | |
GM6001, also known as Ilomastat, is a potent inhibitor of matrix metalloproteinases. Since TIN-Ag is associated with the extracellular matrix, GM6001 can inhibit the degradation of the matrix, thereby potentially inhibiting the functionality of TIN-Ag in processes like cell migration and adhesion. | ||||||
SB-3CT | 292605-14-2 | sc-205847 sc-205847A | 1 mg 5 mg | $102.00 $388.00 | 15 | |
SB-3CT is a selective inhibitor of matrix metalloproteinases 2 and 9. By inhibiting these MMPs, SB-3CT can reduce the degradation of the extracellular matrix which is potentially required for TIN-Ag's function in tissue remodeling and cellular adhesion. | ||||||
NSC 405020 | 7497-07-6 | sc-477738 | 10 mg | $105.00 | ||
NSC 405020 is a selective non-peptidic inhibitor of MMP-14, a membrane-anchored matrix metalloproteinase. TIN-Ag, which could be functionally related to the extracellular matrix, may have its function inhibited by NSC 405020 through the stabilization of the matrix, interfering with TIN-Ag's potential role in matrix degradation or cell-matrix interactions. | ||||||
ARP 100 | 704888-90-4 | sc-203522 | 5 mg | $208.00 | 26 | |
ARP 100 is a selective MMP-2 inhibitor. By specifically targeting MMP-2 activity, ARP 100 can inhibit the breakdown of the extracellular matrix, potentially inhibiting TIN-Ag's function if TIN-Ag's activity involves interaction with or modulation of the extracellular matrix. | ||||||
Batimastat | 130370-60-4 | sc-203833 sc-203833A | 1 mg 10 mg | $179.00 $377.00 | 24 | |
Batimastat is a potent matrix metalloproteinase inhibitor. By inhibiting MMPs, Batimastat could inhibit the extracellular matrix remodeling, which is necessary for TIN-Ag's putative functions related to cell migration and adhesion. | ||||||
PD166793 | 199850-67-4 | sc-202709 | 5 mg | $150.00 | 6 | |
PD166793 is a broad-spectrum MMP inhibitor. It can inhibit the extracellular matrix degradation, possibly leading to the inhibition of TIN-Ag's involvement in cell-matrix interactions, potentially influencing processes like angiogenesis and tissue repair where TIN-Ag may play a role. | ||||||
Ro 32-3555 | 190648-49-8 | sc-296277 | 10 mg | $413.00 | 2 | |
Ro 32-3555 is an MMP inhibitor with specificity towards MMP-9. By inhibiting MMP-9, this chemical can prevent the breakdown of the extracellular matrix components, potentially inhibiting the functional role of TIN-Ag in cellular processes that require matrix remodeling, such as cell migration. | ||||||
WAY 170523 | 307002-73-9 | sc-361402 sc-361402A | 1 mg 10 mg | $275.00 $595.00 | 1 | |
WAY-170523 is a selective inhibitor of MMP-13. The inhibition of MMP-13 can lead to reduced extracellular matrix degradation, which could hinder TIN-Ag's function in cell-matrix interactions and tissue repair processes. | ||||||
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $82.00 $216.00 $416.00 | 48 | |
(R)-SM-19712 is an MMP inhibitor that can prevent the degradation of the extracellular matrix. This could inhibit TIN-Ag's function by stabilizing the matrix environment that TIN-Ag may interact with during cell adhesion or migration processes. | ||||||