Batimastat CAS: 130370-60-4
MF: C23H31N3O4S2
MW: 477.64
A broad spectrum matrix metalloprotease (MMP) inhibitor.

Batimastat (CAS 130370-60-4)

Batimastat | CAS 130370-60-4 is rated 5.0 out of 5 by 1.
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Alternate Names: BB-94
Application: Batimastat is a broad spectrum MMP (matrix metalloprotease) inhibitor
CAS Number: 130370-60-4
Purity: ≥98%
Molecular Weight: 477.64
Molecular Formula: C23H31N3O4S2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

Batimastat is a potent, broad spectrum matrix metalloprotease (MMP) inhibitor, with IC50 values of 3, 4, 4, 6 and 20 nM for MMP-1, MMP-2, MMP-9, MMP-7 and MMP-3 respectively, that has demonstrated antiproliferative, anti-invasive and antimetastatic activity. Batimastat also demonstrated the ability to reduce tumor size and inhibit metastasis in mice implanted with human colon carcinoma cells.


References

1. Davies, B., et al. 1993. Cancer Res. 53: 2087-2091. PMID: 8347186
2. Wang, X., et al. 1994. Cancer Res. 54: 4726-4728. PMID: 8062271
3. Kohn, E.C. and Liotta, L.A. 1995. Cancer Res. 55: 1856-1862. PMID: 7728753

Physical State :
Solid
Solubility :
Soluble in DMSO (100 mM).
Storage :
Store at -20° C
Melting Point :
340.21° C (Predicted)
Boiling Point :
773.20° C (Predicted)
Density :
1.26 g/cm3 (Predicted)
Refractive Index :
n20D 1.61 (Predicted)
IC50 :
MMP -1: IC50 = 3 nM; MMP -2: IC50 = 4 nM; MMP -9: IC50 = 4 nM; MMP -7: IC50 = 6 nM; MMP -3: IC50 = 20 nM
Ki Data :
Matrix metalloproteinase-1: Ki= 0.5 nM (human)
pK Values :
pKa: 9.04
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
EJ6675000
PubChem CID :
5362422
MDL Number :
MFCD00866533
SMILES :
CC(C)C[[email protected]]([[email protected]](CSC1=CC=CS1)C(=O)NO)C(=O)N[[email protected]@H](CC2=CC=CC=C2)C(=O)NC

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Certificate of Analysis

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Batimastat (CAS 130370-60-4)  Product Citations

See how others have used Batimastat (CAS 130370-60-4). Click on the entry to view the PubMed entry .

Citations 1 to 10 of 22 total

PMID: # 30320377  Lu, H.|Chen, J.|Luo, Y.|Xu, H.|Xiong, L.|Fu, J.| et al. 2018. Int. J. Oncol. 53: 2695-2704.

PMID: # 29279286  Segawa, R. et al. 2018. J. Dermatol. Sci. 89: 290-298.

PMID: # 30217259  Fu, J. et al. 2018. Phytomedicine. 49: 23-31.

PMID: # 28070797  Cepeda, MA. et al. 2017. J Cell Commun Signal. 11: 167-179.

PMID: # 27889376  Cepeda, MA. et al. 2017. Exp. Cell Res. 350: 169-183.

PMID: # 26549400  Fu, J. et al. 2016. Oncol. Rep. 35: 117-26.

PMID: # 27756325  Cepeda, MA. et al. 2016. Mol. Cancer. 15: 65.

PMID: # 27080375  Amer, LD. et al. 2016. Ann Biomed Eng. 44: 1959-69.

PMID: # 27297104  Okoro, EU. et al. 2016. Biochemical and biophysical research communications.

PMID: # 27022018  Braley, A. et al. 2016. J. Biol. Chem. 291: 12057-73.

Citations 1 to 10 of 22 total
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Rated 5 out of 5 by from Jim nez Jim nez, N. et al. (PubMed 18449209) used batimastat, a broad spectrum MMP inhibitor, in mice ears that were injected with MMP BaP1 (isolated from B. asper) to understand the pathological alterations induced by snake venom. The main pathological features, hemorrhage and blistering, were nullified when BaP1 was incubated with batimastat indicating these effects were dependent on the proteolytic activity of BaP1. -SCBT Publication Review
Date published: 2015-05-24
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