WAY 170523 (CAS 307002-73-9)

WAY 170523 is a potent and selective chemical inhibitor of the matrix metalloproteinase-13 (MMP-13), a zinc-dependent enzyme involved in the degradation of extracellular matrix components, primarily type II collagen. The inhibition mechanism of WAY 170523 involves the binding to the catalytic domain of MMP-13, effectively preventing the enzyme′s interaction with its substrates. This specific inhibition is significant in research applications where the pathological overexpression of MMP-13 is a concern, particularly in studies related to joint and cartilage diseases, as well as in the investigation of its role in tissue remodeling and disease progression. By selectively targeting MMP-13, WAY 170523 enables researchers to dissect the enzyme′s specific contributions from those of other matrix metalloproteinases, facilitating a clearer understanding of its unique roles in various biological processes. This specificity is for studying the precise mechanisms of tissue degradation and repair, providing insights into the molecular pathways that underlie these processes without the confounding effects of broader-spectrum MMP inhibitors.