Molecular structure of PD166793, CAS Number: 199850-67-4
PD166793 (CAS 199850-67-4)
See product citations (6)
Alternate Names:
MMP-2/MMP-3 Inhibitor III; (S)-2-(4′-Bromo-biphenyl-4-sulfonylamino-3-methylbutyric acid)
Application:
PD166793 is a potent MMP-2, MMP-3, and MMP-13 inhibitor
CAS Number:
199850-67-4
Purity:
>99%
Molecular Weight:
412.30
Molecular Formula:
C17H18BrNO4S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
PD166793 is a cell-permeable compound that strongly inhibits MMP (matrix metalloproteinase) -2, -3, and -13, and weakly inhibits AMP deaminase, MMP-1, -7, -9, and -14. The compound has been used to study MMP′s contribution to the dilation of the left ventricle, that results in left ventricle dysfunction. The MMP inhibitor has demonstrated countering of high energy phosphate depletion in subacute heart failure models.
PD166793 (CAS 199850-67-4) References
- Matrix metalloproteinase inhibition during the development of congestive heart failure : effects on left ventricular dimensions and function. | Spinale, FG., et al. 1999. Circ Res. 85: 364-76. PMID: 10455065
- Angiotensin-converting enzyme and matrix metalloproteinase inhibition with developing heart failure: comparative effects on left ventricular function and geometry. | McElmurray, JH., et al. 1999. J Pharmacol Exp Ther. 291: 799-811. PMID: 10525103
- Matrix metalloproteinase inhibition attenuates left ventricular remodeling and dysfunction in a rat model of progressive heart failure. | Peterson, JT., et al. 2001. Circulation. 103: 2303-9. PMID: 11342481
- Matrix metalloproteinase-2 mediates cytokine-induced myocardial contractile dysfunction. | Gao, CQ., et al. 2003. Cardiovasc Res. 57: 426-33. PMID: 12566115
- Myocardial infarct expansion and matrix metalloproteinase inhibition. | Mukherjee, R., et al. 2003. Circulation. 107: 618-25. PMID: 12566376
- Matrix metalloproteinase abundance in human myocardial fibroblasts: effects of sustained pharmacologic matrix metalloproteinase inhibition. | Chapman, RE., et al. 2003. J Mol Cell Cardiol. 35: 539-48. PMID: 12738235
- Matrix metalloproteinases contribute to insulin insufficiency in Zucker diabetic fatty rats. | Zhou, YP., et al. 2005. Diabetes. 54: 2612-9. PMID: 16123349
- Metalloproteinase inhibitor counters high-energy phosphate depletion and AMP deaminase activity enhancing ventricular diastolic compliance in subacute heart failure. | Paolocci, N., et al. 2006. J Pharmacol Exp Ther. 317: 506-13. PMID: 16436497
- Inhibiting metalloproteases with PD 166793 in heart failure: impact on cardiac remodeling and beyond. | Kaludercic, N., et al. 2008. Cardiovasc Ther. 26: 24-37. PMID: 18466418
- Inhibition of matrix metalloproteinases improves left ventricular function in mice lacking osteopontin after myocardial infarction. | Krishnamurthy, P., et al. 2009. Mol Cell Biochem. 322: 53-62. PMID: 18979185
- Loss of interstitial collagen causes structural and functional alterations of cardiomyocyte subsarcolemmal mitochondria in acute volume overload. | Ulasova, E., et al. 2011. J Mol Cell Cardiol. 50: 147-56. PMID: 21059354
- Matrix metalloproteinase-2 stimulates collagen-I expression through phosphorylation of focal adhesion kinase in rat cardiac fibroblasts. | Hori, Y., et al. 2012. Am J Physiol Cell Physiol. 303: C947-53. PMID: 22914642
- Early citalopram treatment increases mortality due to left ventricular rupture in mice after myocardial infarction. | Frey, A., et al. 2016. J Mol Cell Cardiol. 98: 28-36. PMID: 27397875
- 4-Hexylresorcinol and silk sericin increase the expression of vascular endothelial growth factor via different pathways. | Jo, YY., et al. 2019. Sci Rep. 9: 3448. PMID: 30837602
Inhibitor of:
ADAM20, ADAM23, ADAM24, ADAM25, ADAM26, ADAM26B, ADAM29, ADAM34, ADAM38, ADAMTS-19, ADAMTS-9, ADAMTS-L5, COL6A4, EG384813, EGFL11, EGFL8, Fibulin-7, MCC, MMP-13, MMP-2, MMP-3, MMP-8, MT-MMP-1, MXRA5, MXRA7, Ninjurin-2, PF4V1, SSc5D, TIMP-2, TIN-Ag, TLL1, TLL2, TNFa-IP 8, and WECHE.Activator of:
ADAM18, CMG1, and MT-MMP-6.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PD166793, 5 mg | sc-202709 | 5 mg | $150.00 |