PD166793 CAS: 199850-67-4
MF: C17H18BrNO4S
MW: 412.30
A potent MMP-2, MMP-3, and MMP-13 inhibitor.

PD166793 (CAS 199850-67-4)

PD166793 | CAS 199850-67-4 is rated 5.0 out of 5 by 1.
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Alternate Names: MMP-2/MMP-3 Inhibitor III; (S)-2-(4′-Bromo-biphenyl-4-sulfonylamino-3-methylbutyric acid)
Application: PD166793 is a potent MMP-2, MMP-3, and MMP-13 inhibitor
CAS Number: 199850-67-4
Purity: >99%
Molecular Weight: 412.30
Molecular Formula: C17H18BrNO4S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

PD166793 is a cell-permeable compound that strongly inhibits MMP (matrix metalloproteinase) -2 , -3, and -13, and weakly inhibits AMP deaminase, MMP-1, -7, -9, and -14. The compound has been used to study MMP's contribution to the dilation of the left ventricle, that results in left ventricle dysfunction. The MMP inhibitor has demonstrated countering of high energy phosphate depletion in subacute heart failure models.


References

1. Spinale, F.G., et al. 1999. Circ. Res. 85: 364-376. PMID: 10455065
2. Peterson, J.T., et al. 2001. Circulation. 103: 2303-2309. PMID: 11342481
3. Chapman, R.E., et al. 2003. J. Mol. Cell. Cardiol. 35: 539-548. PMID: 12738235
4. Zhou, Y.P., et al. 2005. Diabetes. 54: 2612-2619. PMID: 16123349
5. Paolocci, N., et al. 2006. J. Pharmacol. Exp. Ther. 317: 506-513. PMID: 16436497

Appearance :
Crystalline
Physical State :
Solid
Solubility :
Soluble in DMSO (100 mM), and ethanol (100 mM).
Storage :
Desiccate at 4° C
Melting Point :
194° C
Boiling Point :
562.07° C at 760 mmHg (Predicted)
Density :
1.46 g/cm3 (Predicted)
Refractive Index :
n20D 1.60 (Predicted)
IC50 :
MMP-2: IC50 = 4 nM (human); MMP-3: IC50 = 7 nM (human); MMP-13: IC50 = 8 nM (human)
Ki Data :
MMP-3: Ki= 4.4 nM
pK Values :
pKa: 3.37 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
RTECS :
EK7713965
PubChem CID :
9887870
MDL Number :
MFCD09038565
SMILES :
CC(C)C(C(=O)O)NS(=O)(=O)C1=CC=C(C=C1)C2=CC=C(C=C2)Br

Download SDS (MSDS)

Certificate of Analysis

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PD166793 (CAS 199850-67-4)  Product Citations

See how others have used PD166793 (CAS 199850-67-4). Click on the entry to view the PubMed entry .

Citations 1 to 6 of 6 total

PMID: # 16436497  Paolocci, N. et al. 2006. J. Pharmacol. Exp. Ther. 317: 506-513.

PMID: # 12566115  Gao, CQ. et al. 2003. Cardiovasc. Res. 57: 426-433.

PMID: # 11342481  Peterson, JT. et al. 2001. Circulation. 103: 2303-2309.

PMID: # 10455065  Spinale, FG. et al. 1999. Circ. Res. 85: 364-376.

PMID: # 10521266  Parker, MH. et al. 1999. Biochemistry. 38: 13592-13601.

PMID: # 23175708  Sci Transl Med. 161ra150.

Citations 1 to 6 of 6 total
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Rated 5 out of 5 by from Paolocci et al Paolocci et al. (PubMed ID 16436497) used PD166793 to inhibit cardiac matrix metalloproteinases. -SCBT Publication Review
Date published: 2015-06-03
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