Molecular structure of Ro 32-3555, CAS Number: 190648-49-8
Ro 32-3555 (CAS 190648-49-8)
See product citations (2)
Alternate Names:
Cipemastat
Application:
Ro 32-3555 is a potent, collagenase-selective MMP inhibitor
CAS Number:
190648-49-8
Purity:
≥97%
Molecular Weight:
436.55
Molecular Formula:
C22H36N4O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Available in US only.
Available in US only.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Ro 32-3555 is a compound that has been the subject of various studies due to its biological activity. It is primarily utilized in biochemical research where it serves as a tool for understanding cellular processes. The compound is often used to investigate the signaling pathways and molecular mechanisms within cells. Research involving Ro 32-3555 contributes to the broader knowledge of cellular responses under different conditions. It is also used in the study of enzyme inhibition, where it helps in identifying the role of specific enzymes in metabolic pathways. Additionally, Ro 32-3555 is valuable for studying protein interactions and the modulation of biological systems.
Ro 32-3555 (CAS 190648-49-8) References
- Matrix metalloproteinase inhibitors in rheumatic diseases. | Close, DR. 2001. Ann Rheum Dis. 60 Suppl 3: iii62-7. PMID: 11890658
- A novel matrix metalloproteinase inhibitor, FYK-1388 suppresses tumor growth, metastasis and angiogenesis by human fibrosarcoma cell line. | Shinoda, K., et al. 2003. Int J Oncol. 22: 281-8. PMID: 12527923
- Matrix metalloproteinase inhibitors. | Brown, PD. 1998. Angiogenesis. 1: 142-54. PMID: 14517381
- Understanding the role of tissue degrading enzymes and their inhibitors in development and disease. | Cawston, TE. and Wilson, AJ. 2006. Best Pract Res Clin Rheumatol. 20: 983-1002. PMID: 16980219
- MMP-1 drives immunopathology in human tuberculosis and transgenic mice. | Elkington, P., et al. 2011. J Clin Invest. 121: 1827-33. PMID: 21519144
- Matrix metalloproteinase inhibition lowers mortality and brain injury in experimental pneumococcal meningitis. | Liechti, FD., et al. 2014. Infect Immun. 82: 1710-8. PMID: 24491581
- Low-Dose and Short-Duration Matrix Metalloproteinase 9 Inhibition Does Not Affect Adhesion Formation during Murine Flexor Tendon Healing. | Orner, CA., et al. 2016. Plast Reconstr Surg. 137: 545e-553e. PMID: 26910699
- Tumor cell density regulates matrix metalloproteinases for enhanced migration. | Jayatilaka, H., et al. 2018. Oncotarget. 9: 32556-32569. PMID: 30220965
- Endogenous Collagenases Regulate Osteoclast Fusion. | Kim, HJ. and Lee, Y. 2020. Biomolecules. 10: PMID: 32370054
- Ro 32-3555, an orally active collagenase inhibitor, prevents cartilage breakdown in vitro and in vivo. | Lewis, EJ., et al. 1997. Br J Pharmacol. 121: 540-6. PMID: 9179398
- Cartilage protective agent (CPA) Ro 32-3555, a new matrix metalloproteinase inhibitor for the treatment of rheumatoid arthritis. | Wood, ND., et al. 1998. Agents Actions Suppl. 49: 49-55. PMID: 9426828
- Ro 32-3555, an orally active collagenase selective inhibitor, prevents structural damage in the STR/ORT mouse model of osteoarthritis. | Brewster, M., et al. 1998. Arthritis Rheum. 41: 1639-44. PMID: 9751097
- Alkylation of succinates: synthesis of Ro 32-3555. | McClure, KF. and Axt, MZ. 1998. Bioorg Med Chem Lett. 8: 143-6. PMID: 9871642
Inhibitor of:
ADAM20, ADAM21, ADAM25, ADAM26, ADAM26B, ADAM29, ADAM34, ADAM38, ADAM39, ADAMTS-20, ADAMTS-L5, BMP-1, C8γ, Ddc8, EGFL11, Enzyme, Fibulin-7, Filamin β, Mast Cell Chymase, Mast Cell Protease 4, METH-1, MMP, MMP-1b, MMP-7, Ninjurin-2, OTTMUSG00000008561, SSc5D, TIMP-2, TIN-Ag, TNFa-IP 8, and WECHE.Activator of:
ADAM8.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Ro 32-3555, 10 mg | sc-296277 | 10 mg | $413.00 | |||
| US: Only available in the US | ||||||