Marimastat (BB-2516) is a broad spectrum matrix metalloprotease (MMP) inhibitor with specificity towards MMP-9, MMP-1, MMP-2, MMP-14 and MMP-7 and IC50 values of 3, 5, 6, 9 and 13 nM, respectively. MMPs are a homologous family of enzymes involved in tissue remodeling and morphogenesis. They are collectively capable of degrading all components of the extracellular matrix, and also play an important role in wound healing and other processes involving tissue remodeling. Research shows that marimastat inhibits CD30 shedding in Karpas 299 cells (IC50 = 1 μM) and LPS-induced soluble TNFα production in a dose-dependent manner. The enzyme tumor necrosis factor alpha convertase (TACE), reported to be closely related to matrix metalloproteinases, is responsible for the processing of pro-TNFα to TNFα and is specifically inhibited by marimastat (IC50 = 3.8 nM). Studies show that this peptide hydroxamate compound also inhibits peritoneal dissemination of human gastric cancer cells through tumor angiogenesis inhibition.
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See how others have used Marimastat (CAS 154039-60-8). Click on the entry to view the PubMed entry .
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