Molecular structure of ARP 100, CAS Number: 704888-90-4
ARP 100 (CAS 704888-90-4)
See product citations (26)
Alternate Names:
ARP 100 is also known as Matrix Metalloproteinase-2 Inhibitor III.
Application:
ARP 100 is a biphenylsulfonamide and selective inhibitor of MMP-2, also capable of suppressing the invasive behavior of HT1080 tumor cells.
CAS Number:
704888-90-4
Purity:
≥98%
Molecular Weight:
364.42
Molecular Formula:
C17H20N2O5S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
ARP 100 is a selective inhibitor of MMP-2 (IC50 = 12 nM). ARP 100 displays selectivity over MMP-9, MMP-3, MMP-1 and MMP-7 (IC50 values are 200, 4500, > 50000 and > 50000 nM respectively). ARP 100 exhibits anti-invasive properties in HT1080 fibrosarcoma cells.
ARP 100 (CAS 704888-90-4) References
- MMP-2 alters VEGF expression via alphaVbeta3 integrin-mediated PI3K/AKT signaling in A549 lung cancer cells. | Chetty, C., et al. 2010. Int J Cancer. 127: 1081-95. PMID: 20027628
- Tumor necrosis factor-α induces aortic intima-media thickening via perivascular adipose tissue inflammation. | Moe, KT., et al. 2013. J Vasc Res. 50: 228-37. PMID: 23711955
- Inhibitory effects of caspase inhibitors on the activity of matrix metalloproteinase-2. | Castro, MM., et al. 2013. Biochem Pharmacol. 86: 469-75. PMID: 23774623
- Matrix metalloproteinase-2 in oncostatin M-induced sarcomere degeneration in cardiomyocytes. | Fan, X., et al. 2016. Am J Physiol Heart Circ Physiol. 311: H183-9. PMID: 27199120
- Adrenomedullin promotes the growth of pancreatic ductal adenocarcinoma through recruitment of myelomonocytic cells. | Xu, M., et al. 2016. Oncotarget. 7: 55043-55056. PMID: 27391260
- Doxorubicin induces de novo expression of N-terminal-truncated matrix metalloproteinase-2 in cardiac myocytes. | Chan, BYH., et al. 2018. Can J Physiol Pharmacol. 96: 1238-1245. PMID: 30308129
- Myocardial MMP-2 contributes to SERCA2a proteolysis during cardiac ischaemia-reperfusion injury. | Roczkowsky, A., et al. 2020. Cardiovasc Res. 116: 1021-1031. PMID: 31373602
- Junctophilin-2 is a target of matrix metalloproteinase-2 in myocardial ischemia-reperfusion injury. | Chan, BYH., et al. 2019. Basic Res Cardiol. 114: 42. PMID: 31506724
- Pyridine-Containing Macrocycles Display MMP-2/9 Inhibitory Activity and Distinct Effects on Migration and Invasion of 2D and 3D Breast Cancer Models. | Proença, S., et al. 2019. Int J Mol Sci. 20: PMID: 31618886
- Matrix Metalloproteinases Repress Hypertrophic Growth in Cardiac Myocytes. | Euler, G., et al. 2021. Cardiovasc Drugs Ther. 35: 353-365. PMID: 33400052
- Staurosporine-induced cleavage of apoptosis-inducing factor in human fibrosarcoma cells is independent of matrix metalloproteinase-2. | Bassiouni, W., et al. 2022. Can J Physiol Pharmacol. 100: 184-191. PMID: 34597523
- Naringin dihydrochalcone potentially binds to catalytic domain of matrix metalloproteinase-2: molecular docking, MM-GBSA, and molecular dynamics simulation approach. | Singh, AK. and Kumar, S. 2022. Nat Prod Res. 1-5. PMID: 36047975
- The ACE Inhibitor Lisinopril Stimulates Melanoma Cell Invasiveness by Inducing MMP2 Secretion. | Becker, Y. and Stock, C. 2022. Cell Physiol Biochem. 56: 457-483. PMID: 36057984
Inhibitor of:
ADAM21, ADAM26B, ADAMTS-17, ADAMTS-19, ADAMTS-8, COL6A4, Fibulin-7, ITFG2, M-ficolin, MCC, MMP, MMP-12, MMP-2, MMP-7, MMP-9, TIMP-2, TIMP-3, TIMP-4, TIN-Ag, TLL1, TLL2, and TTC30A2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ARP 100, 5 mg | sc-203522 | 5 mg | $121.00 |