ARP 100 CAS: 704888-90-4
MF: C17H20N2O5S
MW: 364.42
A selective inhibitor of MMP-2.

ARP 100 (CAS 704888-90-4)

ARP 100 | CAS 704888-90-4 is rated 5.0 out of 5 by 1.
  • y_2020, m_7, d_4, h_15
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.10
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_203522, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 132ms
  • REVIEWS, PRODUCT
5
1
4
0
3
0
2
0
1
0
Alternate Names: MMP-2 Inhibitor III
Application: ARP 100 is a selective inhibitor of MMP-2
CAS Number: 704888-90-4
Purity: ≥98%
Molecular Weight: 364.42
Molecular Formula: C17H20N2O5S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

ARP 100 is a selective inhibitor of MMP-2 (IC50 = 12 nM); displays selectivity over MMP-9, MMP-3, MMP-1 and MMP-7 (IC50 values are 200, 4500, > 50000 and > 50000 nM respectively). ARP 100 exhibits anti-invasive properties in HT1080 fibrosarcoma cells.


References

1. Rossello, Armando., et al., 2004. New N-arylsulfonyl-N-alkoxyaminoacetohydroxamic acids as selective inhibitors of gelatinase A (MMP-2). Bioorganic & medicinal chemistry. 12(9): 2441-50. PMID: 15080939
2. Tuccinardi, Tiziano., et al., 2006. Amber force field implementation, molecular modelling study, synthesis and MMP-1/MMP-2 inhibition profile of (R)- and (S)-N-hydroxy-2-(N-isopropoxybiphenyl-4-ylsulfonamido)-3-methylbutanamides. Bioorganic & medicinal chemistry. 14(12): 4260-76. PMID: 16483784
3. Lauer-Fields, Janelle L., et al., 2008. Screening of potential a disintegrin and metalloproteinase with thrombospondin motifs-4 inhibitors using a collagen model fluorescence resonance energy transfer substrate. Analytical biochemistry. 373(1): 43-51. PMID: 17949675

Physical State :
Solid
Solubility :
Soluble in DMSO (100 mM), 1:10 EtOH:PBS(PH 7.2) (0.1 mg/ml), DMF (25 mg/ml), and ethanol (25 mg/ml).
Storage :
Store at -20° C
Density :
~1.30 g/cm3 (Predicted)
Refractive Index :
n20D 1.59 (Predicted)
IC50 :
MMP-2: IC50 = 12 nM; MMP-9: IC50 = 200 nM; MMP-13: IC50 = 25 nM (human)
Ki Data :
MMP-2: Ki= 13 nM (human); MMP-13: Ki= 20 nM (human)
pK Values :
pKa: 8.98 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
10044321
MDL Number :
MFCD09971105
SMILES :
CC(C)ON(CC(=O)NO)S(=O)(=O)C1=CC=C(C=C1)C2=CC=CC=C2

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

ARP 100 (CAS 704888-90-4)  Product Citations

See how others have used ARP 100 (CAS 704888-90-4). Click on the entry to view the PubMed entry .

Citations 1 to 10 of 16 total

PMID: # 30497805  Roncevic, J.|Djoric, I.|Selemetjev, S.|Jankovic, J.|Dencic, TI.|Bozic, V.|Cvejic, D.| et al. 2019. Pathology. 51: 55-61.

PMID: # 31105008  Cho, S.|Vashisth, M.|Abbas, A.|Majkut, S.|Vogel, K.|Xia, Y.|Ivanovska, IL.|Irianto, J.|Tewari, M.|Zhu, K.|Tichy, ED.|Mourkioti, F.|Tang, HY.|Greenberg, RA.|Prosser, BL.|Discher, DE.| et al. 2019. Dev. Cell. 49: 920-935.e5.

PMID: # 29573200  Higuchi, T.|Takeuchi, A.|Munesue, S.|Yamamoto, N.|Hayashi, K.|Kimura, H.|Miwa, S.|Inatani, H.|Shimozaki, S.|Kato, T.|Aoki, Y.|Abe, K.|Taniguchi, Y.|Aiba, H.|Murakami, H.|Harashima, A.|Yamamoto, Y.|Tsuchiya, H.| et al. 2018. Cancer Med. 7: 1944-1954.

PMID: # 28785738  Lim, Y. et al. 2017. Dev Reprod. 21: 167-180.

PMID: # 28205580  Jo, YY.|Kweon, H.|Kim, DW.|Kim, MK.|Kim, SG.|Kim, JY.|Chae, WS.|Hong, SP.|Park, YH.|Lee, SY.|Choi, JY.| et al. 2017. Sci Rep. 7: 42441.

PMID: # 29102636  Deiana, M.|Calfapietra, S.|Incani, A.|Atzeri, A.|Rossin, D.|Loi, R.|Sottero, B.|Iaia, N.|Poli, G.|Biasi, F.| et al. 2017. Free Radic. Biol. Med. 113: 539-550.

PMID: # 28633655  Webb, AH. et al. 2017. BMC Cancer. 17: 434.

PMID: # 29137358  Song, DG. et al. 2017. Oncotarget. 8: 83480-83494.

PMID: # 26503968  Romero, D. et al. 2016. Carcinogenesis. 37: 18-29.

PMID: # 27345135  Yan, Y.|Bejoy, J.|Xia, J.|Guan, J.|Zhou, Y.|Li, Y.| et al. 2016. Acta Biomater. 42: 114-126.

Citations 1 to 10 of 16 total

What is the working concentration of this product for primary fibroblasts?

Asked by: Baltanas
Thank you for your question. Unfortunately we do not have this information, so we are unable to provide it for you.
Answered by: Tech Service
Date published: 2019-10-14

Has ARP100(sc-203522) been tested or shown to be effective in-vivo? If so do you know the suggested dosage and route of delivery (IV, IP, SC...etc)?

Asked by: CLab
Unfortunately we are not able to provide that information. Our compounds are not pharmaceutical grade and not manufactured under GMP guidelines. Please consult your principal investigator and your animal care and use committee (ACUC) regarding the use of our compounds.
Answered by: Technical Support
Date published: 2018-11-30

Is ARP 100 a reversible inhibitor?

Asked by: ChemSynth123
Thank you for your question. ARP 100 (CAS 704888-90-4): sc-203522 does seem to be a reversible inhibitor of matrix metalloproteinases. (Lauer-Fields, Janelle L., et al., 2008. Analytical biochemistry. 373(1): 43-51. PMID: 17949675)
Answered by: Chemical Support 7
Date published: 2017-03-02

Is sc-203522 cell-impermeable?

Asked by: Chemsynth123
Thank you for your question. ARP 100, sc-203522, is cell-permeable.
Answered by: TechService7
Date published: 2017-02-10
  • y_2020, m_7, d_4, h_15CST
  • bvseo_bulk, prod_bvqa, vn_bulk_3.0.10
  • cp_1, bvpage1
  • co_hasquestionsanswers, tq_4
  • loc_en_US, sid_203522, prod, sort_[SortEntry(order=LAST_APPROVED_ANSWER_SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 155ms
  • QUESTIONS, PRODUCT
Rated 5 out of 5 by from Castro Castro, et al. (PubMed ID 23774623) found that ARP 100 and Ac-LEHD-cmk blocked troponin I (Tnl) degradation (due to hypoxia-reoxygenation) in neonatal cardiomyocytes. -SCBT Publication Review
Date published: 2015-06-14
  • y_2020, m_7, d_4, h_15
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.10
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_203522, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 26ms
  • REVIEWS, PRODUCT

Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2020 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.