RNF150 Inhibitors
RNF150 operates within the vast ubiquitin-proteasome system (UPS), a key cellular pathway responsible for protein degradation and turnover. By modulating the UPS, it's feasible to indirectly influence the function of E3 ubiquitin ligases such as RNF150. Several inhibitors like MG132, Bortezomib, and Lactacystin are specifically known for their ability to inhibit the proteasome, the primary degradation machinery within the UPS. In doing so, they affect the balance of protein ubiquitination and degradation, which can in turn impact RNF150's role within the system.
Another approach to modulating the UPS is by targeting enzymes upstream of the E3 ligases. Compounds like PYR-41 and MLN4924 (Pevonedistat) inhibit the E1 activating enzyme and the NEDD8-activating enzyme, respectively. By disrupting these early steps in the ubiquitination cascade, the downstream function of E3 ligases like RNF150 can be influenced. Nutlin-3 and RITA, on the other hand, specifically modulate p53 ubiquitination, shedding light on the intricate interplay between different proteins in the UPS.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $60.00 $265.00 $1000.00 | 163 | |
Proteasome inhibitor that affects ubiquitin-proteasome system, potentially influencing RNF150 function. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $135.00 $1085.00 | 115 | |
Proteasome inhibitor that can modify the ubiquitin-proteasome pathway, potentially affecting RNF150 activity. | ||||||
MLN 4924 | 905579-51-3 | sc-484814 | 1 mg | $286.00 | 1 | |
NEDD8-activating enzyme inhibitor; affects neddylation process, potentially impacting RNF150 function. | ||||||
Ubiquitin E1 Inhibitor, PYR-41 | 418805-02-4 | sc-358737 | 25 mg | $360.00 | 4 | |
Inhibits ubiquitin-activating enzyme E1, potentially affecting the ubiquitin pathway and indirectly RNF150. | ||||||
Nutlin-3 | 548472-68-0 | sc-45061 sc-45061A sc-45061B | 1 mg 5 mg 25 mg | $62.00 $225.00 $779.00 | 24 | |
MDM2-p53 interaction disruptor, influencing ubiquitination and potentially RNF150's activity. | ||||||
p53 Activator III, RITA | 213261-59-7 | sc-202753 sc-202753A sc-202753B sc-202753C | 1 mg 10 mg 100 mg 500 mg | $112.00 $273.00 $1564.00 $5205.00 | 9 | |
Binds to p53, preventing its ubiquitination; can indirectly influence ubiquitin ligases like RNF150. | ||||||
Lactacystin | 133343-34-7 | sc-3575 sc-3575A | 200 µg 1 mg | $188.00 $575.00 | 60 | |
Proteasome inhibitor that modulates the ubiquitin-proteasome system and can affect RNF150 function. | ||||||
Thalidomide | 50-35-1 | sc-201445 sc-201445A | 100 mg 500 mg | $111.00 $357.00 | 8 | |
Targets cereblon, affecting ubiquitin ligase activity and potentially influencing RNF150. | ||||||
Lenalidomide | 191732-72-6 | sc-218656 sc-218656A sc-218656B | 10 mg 100 mg 1 g | $50.00 $374.00 $2071.00 | 18 | |
Modulates cereblon E3 ubiquitin ligase activity, potentially impacting RNF150. | ||||||
Carfilzomib | 868540-17-4 | sc-396755 | 5 mg | $41.00 | ||
Proteasome inhibitor; affects the ubiquitin-proteasome system and can influence RNF150. | ||||||