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MG-132 [Z-Leu-Leu-Leu-CHO] is a potent, reversible, and cell-permeable proteasome inhibitor, used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. These proteins processed by the proteasome are involved in inflammatory processes and cell cycle regulation, presenting broad relevance for aldehydic proteasome inhibitors of this type. For instance, MG-132 suppresses NF-κB activation (at 10 μM) by preventing IκB degradation (IC50=3 μM), which blocks the transcription factor from providing chemoresistance to cancer cells. Also, MG-132 has been shown to prevent beta-secretase cleavage of amyloid precursor protein (APP). Additionally, MG-132 is an inhibitor of 26S Proteasome and calpain, as well as, an activator of JNK1, c-Jun and c-Fos.
Related products include sc-351846 (sc-351846).
1. Lee, D.H. and Goldberg, A.L. 1998. Trends Cell Biol. 8: 397-403. PMID: 9789328
2. Arlt, A., et al. 2001. Oncogene. 20: 859-868. PMID: 11314019
3. Steinhilb, M. L., et al. 2001. J Biol Chem. 276(6):4476-4484. PMID: 11084038
4. Elliott, P.J., et al. 2003. J. Mol. Med. 81: 235-245. PMID: 12700891
5. Vivier, M., et al. 2008. J. Med. Chem. 51: 1043-1047. PMID: 18237109
6. Ye, X. et al. 2014. PLoS Pathog. 10(4): e1004070. PMID: 24722419
See how others have used MG-132 [Z-Leu-Leu-Leu-CHO]. Click on the entry to view the PubMed entry .
PMID: # 31086178 Dabral, S. et al. 2019. Nat Commun. 10: 2130.
PMID: # 30849304 Rosas, MG. et al. 2019. Biochem. Pharmacol. 163: 362-370.
PMID: # 31052354 Yang, IH. et al. 2019. Molecules. 24:
PMID: # 31078367 Joa, H. et al. 2019. Phytomedicine. 152938.
PMID: # 31222373 Luo, Y. et al. 2019. Cell. Mol. Life Sci.
PMID: # 30821592 Peng, M.|Wang, J.|Tian, Z.|Zhang, D.|Jin, H.|Liu, C.|Xu, J.|Li, J.|Hua, X.|Xu, J.|Huang, C.|Huang, C.| et al. 2019. Autophagy.
PMID: # 29355525 Kim, JL. et al. 2018. Biochem. Biophys. Res. Commun. 496: 633-640.
PMID: # 29467492 Di Costanzo, A. et al. 2018. Oncogene. 37: 2559-2572.
PMID: # 29884303 Ullah, R. et al. 2018. Placenta. 66: 57-64.
PMID: # 29321329 St Gelais, C. et al. 2018. J. Virol. 92:
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