Molecular structure of Ubiquitin E1 Inhibitor, PYR-41, CAS Number: 418805-02-4
Ubiquitin E1 Inhibitor, PYR-41 (CAS 418805-02-4)
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Application:
Ubiquitin E1 Inhibitor, PYR-41 is a cell-permeable pyrazone that irreversibly inhibits ubiquitin-activating enzyme E1 activity
CAS Number:
418805-02-4
Purity:
≥90% (sum of two isomers)
Molecular Weight:
425.35
Molecular Formula:
C17H13N3O7•3H2O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Ubiquitin E1 Inhibitor, PYR-41 is a cell-permeable pyrazone compound that is reported to irreversibly inhibit UBE1 (ubiquitin-activating enzyme E1) activity, in addition to exhibiting little or no activity against E3, E2, or caspase enzymatic activity. Ubiquitin E1 Inhibitor, PYR-41 is also reported to block ubiquitination-dependent protein degradation and other ubiquitination-mediated cellular activities. E1 inactivation by PYR-41 or other means has been shown to result in an overall elevation of sumoylation.
Ubiquitin E1 Inhibitor, PYR-41 (CAS 418805-02-4) References
- Inhibitors of ubiquitin-activating enzyme (E1), a new class of potential cancer therapeutics. | Yang, Y., et al. 2007. Cancer Res. 67: 9472-81. PMID: 17909057
- Regulation of Sperm Capacitation by the 26S Proteasome: An Emerging New Paradigm in Spermatology. | Kerns, K., et al. 2016. Biol Reprod. 94: 117. PMID: 27053366
- Ubiquitin-activating enzyme E1 inhibitor PYR-41 retards sperm enlargement after fusion to the egg. | Yoshida, K., et al. 2018. Reprod Toxicol. 76: 71-77. PMID: 29355596
- PYR-41 and Thalidomide Impair Dendritic Cell Cross-Presentation by Inhibiting Myddosome Formation and Attenuating the Endosomal Recruitments of p97 and Sec61 via NF-κB Inactivation. | You, X., et al. 2018. J Immunol Res. 2018: 5070573. PMID: 30069488
- Administration of ubiquitin-activating enzyme UBA1 inhibitor PYR-41 attenuates angiotensin II-induced cardiac remodeling in mice. | Shu, Q., et al. 2018. Biochem Biophys Res Commun. 505: 317-324. PMID: 30249396
- Inhibition of the Ubiquitin-Activating Enzyme UBA1 Suppresses Diet-Induced Atherosclerosis in Apolipoprotein E-Knockout Mice. | Liao, J., et al. 2020. J Immunol Res. 2020: 7812709. PMID: 32258175
- UBE1a Suppresses Herpes Simplex Virus-1 Replication. | Ikeda, M., et al. 2020. Viruses. 12: PMID: 33291814
- Cross-species identification of PIP5K1-, splicing- and ubiquitin-related pathways as potential targets for RB1-deficient cells. | Parkhitko, AA., et al. 2021. PLoS Genet. 17: e1009354. PMID: 33591981
- PYR-41, an inhibitor of ubiquitin-activating enzyme E1, attenuates 2,4-dinitrochlorobenzene-induced atopic dermatitis-like skin lesions in mice. | Yang, L., et al. 2023. FASEB J. 37: e23210. PMID: 37738047
- The Ubiquitin-Proteasome System Facilitates Membrane Fusion and Uncoating during Coronavirus Entry. | Yuan, X., et al. 2023. Viruses. 15: PMID: 37896778
Inhibitor of:
4732471D19Rik, 4930444G20Rik, 4930524E20Rik, 9930039A11Rik, APC10, APC2, ARIH1, ASB-11, ASB-12, ASB-3, ASB-7, ASXL2, BTBD2, BTBD6, C12orf51, C3orf16, CBLL1, Cdc34B, CG018, Dcun1D5, Deltex (DTX; E3 ubiquitin ligase), Dorfin, DTWD1, EAP1, EG546638, EG665802, EG668359, EULIR, Fbxo12, Fbxo12J, FBXO21, FBXO38, FBXO41, FBXO48, FBXW10, Fbxw12, Fbxw13, Fbxw16, FBXW17, Fbxw19, FBXW2, FBXW23, FBXW5, FBXW9, G2E3, Gm410, Gm514, HECTD1, HECTD2, HECTD3, HECTD4, Herc2, Herc6, IBRDC1, IQUB, KBTBD11, KBTBD13, KBTBD4, KBTBD5, KLHDC10, KLHDC2, KLHDC5, KLHDC8B, KLHL21, KLHL38, KLHL6, LNX1, LRSAM1, MAGE-L2, MARCH (membrane associated ring-CH-type finger), mKIAA1530, MOZ, MuRF2, NEDL1, NEURL4, NHLRC3, Nulp1, OTC, OTUD2, OTUD7A, PBF, Pellino 3, PJA2, PLAA, QPCTL, Rfp2, RFPL4A, RING1B, RLIM, RMND5A, RMND5B, RNF10, RNF103, RNF113A, RNF113A1, RNF113A2, RNF115, RNF138, RNF145, RNF148, RNF150, RNF151, RNF184, RNF214, RNF220, RNF222, RNF26, RNF32, RNF38, RNF39, RNF40, RNF44, Rsp5, Rub1, STAMBP, SUMO-1, SUMO-3, TMEM129, TRIM11, TRIM4, TRIM41, TRIM58, UBC, UBC2, UBC9, UBCE7IP4, UBE1, UBE1L2, UBE2C, UBE2CBP, UBE2D1, UBE2G1, UBE2G2, UBE2H, UBE2J1, UBE2Q1, UBE2QL1, UBE2Z, UBE3C, UBE4A, Ubp-M, UBQLNL, Ubr1, Ubr7, UBTD1, UBTD2, USP17L, USP27X, USP29, USP40, USP50, USP52, WISP-3, ZFAND2B, and ZSWIM1.Activator of:
APC11, ARKL1_Arkadia 2, ASB-1, ASB-13, ASB-17, ASB-5, Axotrophin, C19orf62_5430437P03Rik, Cdc34, Cdc53, CSN7b, CUL-7, Dcun1D3, FBX23, FBXO11, Fbxo12J, FBXO18, FBXO29, FBXO39, Fbxw13, Gm410, Gm514, HAUSP, HIV-1 Vif, KLHL10, KLHL11, KLHL24, KLHL36, KLHL4, LNX3, LNX4, MARCH6, Ndfip1, OTUB2, OTUD4, OTUD5, OTUD6A, OTUD6B, Pin4, PSMD13, Rbx1, Rbx2, RFFL, RFPL1, RFPL2, RNF122, RNF149, RNF166, RNF186, RNF222, RNF23, RNF4, Rpn11, SENP5, SUMO-4, TIP120A, TRIM42, TRIM54, UBC2, UBE1Y1, UBE2B, UBE2D4, UBE2E3, UBE2J2, UBE2L3, UBE2Q2, UBE2QL1, UBE2U, UBE2W, UBE2Z, UBE4A, UBL3, UBL5, UBPY, UCH-L4, UFD2, USP10, USP17L29, USP17L4, USP17L7, USP17L8, USP25, USP31, USP47, USP48, USP6, USP9Y, USPL1, v-SNARE Vti1p, ZMAT2, and ZNRF2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Ubiquitin E1 Inhibitor, PYR-41, 25 mg | sc-358737 | 25 mg | $360.00 |