Lenalidomide CAS: 191732-72-6
MF: C13H13N3O3
MW: 259.26
A thalidomide analog known to have immunomodulatory properties.

Lenalidomide (CAS 191732-72-6)

Lenalidomide | CAS 191732-72-6 is rated 5.0 out of 5 by 1.
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Synonym: (3S)-3-(4-Amino-1-oxo-1,3-dihydro-2H-isoindol-2-yl)piperidine-2,6-dione; Revlimid
Application: A thalidomide analog known to have immunomodulatory properties
CAS Number: 191732-72-6
Purity: ≥99%
Molecular Weight: 259.26
Molecular Formula: C13H13N3O3
* Refer to Certificate of Analysis for lot specific data (including water content).
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Lenalidomide is a thalidomide analog known to inhibit TNF-α secretion and possess immunomodulatory properties.


References

Bartlett, J.B., et al.: Nature Rev., 4, 314 (2004), Mitsiades, C.S., et al.: Curr. Opin. Invest. Drugs, 5, 635 (2004), List, A., et al.: N. Engl. J. Med., 352, 549 (2005),

Physical State :
Solid
Solubility :
Soluble in DMSO (≥52 mg/ml) at 25° C, methanol and water (2: 1), buffered aqueous solvents, water (<1 mg/ml) at 25° C, and ethanol (<1 mg/ml) at 25° C.
Storage :
Store at -20° C
Melting Point :
269-271° C (lit.)
Boiling Point :
613.99° C at 760 mmHg (Predicted)
Density :
1.46 g/cm3 (Predicted)
Refractive Index :
n20D 1.67 (Predicted)
IC50 :
lipopolysaccharide stimulated TNF-alpha release: IC50 = 100 nM (human whole blood)
pK Values :
pKa: 10.75 (Predicted), pKb: 2.77 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
RTECS :
TM7342160
PubChem CID :
216326
MDL Number :
MFCD07772307
SMILES :
C1CC(=O)NC(=O)C1N2CC3=C(C2=O)C=CC=C3N

Download SDS (MSDS)

Certificate of Analysis

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Lenalidomide  Product Citations

See how others have used Lenalidomide. Click on the entry to view the PubMed entry .

Citations 1 to 7 of 7 total

PMID: # 30954557  Brünnert, D.|Kraus, M.|Stühmer, T.|Kirner, S.|Heiden, R.|Goyal, P.|Driessen, C.|Bargou, RC.|Chatterjee, M.| et al. 2019. Biochim Biophys Acta Mol Basis Dis. 1865: 1666-1676.

PMID: # 29296798  Chari, A. et al. 2017. Blood Adv. 1: 1575-1583.

PMID: # 27536332  Osawa, M. et al. 2016. Infect. Agents Cancer. 11: 37.

PMID: # 26790725  Matsumoto, T. et al. 2016. Leukemia research. 41: 103-10.

PMID: # 25617756  Matsushita, M. et al. 2015. PLoS ONE. 10: e0116135.

PMID: # 24973445  Gomez, AM. et al. 2014. Journal of immunology (Baltimore, Md. : 1950). 193: 1055-63.

PMID: # 22766978  Kawano, Y. et al. 2012. Int. J. Oncol. 41: 876-84.

Citations 1 to 7 of 7 total

Can I dissolve the powder to DMSO and store at -80&deg; C for long time use?

Asked by: two2igm05
Thank you for your question. sc-218656 has the following solubility in DMSO: Solubility (25&deg;C) *in vitro 52 mg/mL (200.57 mM). We recommend storing as a powder for long time storage at-20℃, and for up to 6 months at -80℃ in solvent.
Answered by: Technical Support
Date published: 2018-05-16
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Rated 5 out of 5 by from Dong Dong, et. al. (PubMed ID 26255966) investigated the use of lenalidomide as a potential treatment of neovascular ocular diseases. The effect of treatment with this compound was studied on endothelial cell function in vitro and ocular angiogenesis in vivo was studied. -SCBT Publication Review
Date published: 2015-01-14
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