Molecular structure of Lactacystin, CAS Number: 133343-34-7
Lactacystin (CAS 133343-34-7)
See product citations (60)
Alternate Names:
N-Acetyl-S-{[(2R,3S,4R)-3-hydroxy-2-(1-hydroxy-2-methylpropyl)-4-methyl-5-oxo-2-pyrrolidinyl]carbonyl}-L-cysteine
Application:
Lactacystin is a proteasome inhibitor and cathepsin A inhibitor.
CAS Number:
133343-34-7
Purity:
>98%
Molecular Weight:
376.43
Molecular Formula:
C15H24N2O7S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Product Citations
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
Lactacystin is a potent and selective irreversible proteasome inhibitor and cathepsin A inhibitor. Additionally, it is a microbial metabolite found in Streptomyces first characterized by its ability to induce differentiation and inhibit cell cycle progression in several tumor cell lines. Lactacystin irreversibly alkylates subunit X of the 20S proteasome. The concomitant inhibition of proteasome peptidase activity results in the accumulation of a variety of ubiquitinated proteins. Thus, the effects of this substance are pleiotropic and depend substantially on the expression pattern of signaling proteins within the treated cell. It is shown to inhibit cell proliferation and to induce neurite outgrowth in murine neuroblastoma cell lines such as Neuro 2a.
Lactacystin (CAS 133343-34-7) References
- Differential effects of lactacystin on cytokine production in activated Jurkat cells and murine splenocytes. | Rockwell, CE. and Qureshi, N. 2010. Cytokine. 51: 12-7. PMID: 20427199
- Lactacystin, a proteasome inhibitor, enhances BMP-induced osteoblastic differentiation by increasing active Smads. | Ito, Y., et al. 2011. Biochem Biophys Res Commun. 407: 225-9. PMID: 21377449
- Different effects of intranigral and intrastriatal administration of the proteasome inhibitor lactacystin on typical neurochemical and histological markers of Parkinson's disease in rats. | Lorenc-Koci, E., et al. 2011. Neurochem Int. 58: 839-49. PMID: 21419185
- [Effect of epigallocatechin gallate on lactacystin-induced PC12 cell injury]. | Dai, MF., et al. 2011. Zhongguo Zhong Xi Yi Jie He Za Zhi. 31: 672-5. PMID: 21812272
- The proteasome inhibitor lactacystin exerts its therapeutic effects on glioma via apoptosis: an in vitro and in vivo study. | Wang, H., et al. 2013. J Int Med Res. 41: 72-81. PMID: 23569132
- Presence of proNGF-sortilin signaling complex in nigral dopamine neurons and its variation in relation to aging, lactacystin and 6-OHDA insults. | Xia, Y., et al. 2013. Int J Mol Sci. 14: 14085-104. PMID: 23880857
- Proteasome inhibitor lactacystin enhances cisplatin cytotoxicity by increasing endoplasmic reticulum stress-associated apoptosis in HeLa cells. | Xu, Y., et al. 2015. Mol Med Rep. 11: 189-95. PMID: 25323748
- Streptomyces lactacystinicus sp. nov. and Streptomyces cyslabdanicus sp. nov., producing lactacystin and cyslabdan, respectively. | Také, A., et al. 2015. J Antibiot (Tokyo). 68: 322-7. PMID: 25491896
- Application of two direct C(sp3)-H functionalizations for total synthesis of (+)-lactacystin. | Yoshioka, S., et al. 2015. Org Lett. 17: 90-3. PMID: 25526222
- The proteasome inhibitor lactacystin enhances GSH synthesis capacity by increased expression of antioxidant components in an Nrf2-independent, but p38 MAPK-dependent manner in rat colorectal carcinoma cells. | Huseby, NE., et al. 2016. Free Radic Res. 50: 1-13. PMID: 26530909
- Associated degeneration of ventral tegmental area dopaminergic neurons in the rat nigrostriatal lactacystin model of parkinsonism and their neuroprotection by valproate. | Harrison, IF., et al. 2016. Neurosci Lett. 614: 16-23. PMID: 26742637
- Early increase in dopamine release in the ipsilateral striatum after unilateral intranigral administration of lactacystin produces spontaneous contralateral rotations in rats. | Konieczny, J., et al. 2016. Neuroscience. 324: 92-106. PMID: 26964686
- Inhibition of proteasome activities and subunit-specific amino-terminal threonine modification by lactacystin. | Fenteany, G., et al. 1995. Science. 268: 726-31. PMID: 7732382
- A beta-lactone related to lactacystin induces neurite outgrowth in a neuroblastoma cell line and inhibits cell cycle progression in an osteosarcoma cell line. | Fenteany, G., et al. 1994. Proc Natl Acad Sci U S A. 91: 3358-62. PMID: 8159752
- Mechanistic studies on the inactivation of the proteasome by lactacystin: a central role for clasto-lactacystin beta-lactone. | Dick, LR., et al. 1996. J Biol Chem. 271: 7273-6. PMID: 8631740
Inhibitor of:
α2ML1, 20S Proteasome, 20S Proteasome α2, 20S Proteasome α8, 20S Proteasome β1, 20S Proteasome β3, 20S Proteasome β5, 20S Proteasome β7, 26S Proteasome α, 26S Proteasome p50, 26S Proteasome p58, 2900016B01Rik, 2B28, 4930524E20Rik, 4931431F19Rik, 4933402E13Rik, 4933422H20Rik, 5430419D17Rik, 8030411F24Rik, 9930039A11Rik, ACP2, ALS2CR16, ANKRD13A, APC10, APC11, APC2, APC4, apoL10a, apoL10b, ARIH1, ARRDC5, ASB-1, ASB-11, ASB-12, ASB-3, ASB-9, ASXL2, AUTS2, AV320801, B020004J07Rik, BLM hydrolase, BTBD2, BTBD6, C12orf51, C2orf53, C4orf30, C6orf113, CacyBP, Calpain 15_Solh, cathepsin A, CBLL1, Cdc23, Cdc26, Cdt2, CG018, CLAP, CLPSL1, CLPX, CPA5, CPAMD8, CSN3, CSN7a, CSN7b, CST, CSTL1, CUL-7, cystatin 10, cystatin 9, Dcun1D5, Dda1, DDI2, Derlin-1, DET1, Dorfin, DPH5, DsRed2, DTD2, DTWD1, E2ig5, EG382106, EG382156, EG639396, EG665802, EG667977, EG668359, EMC (ER Membrane Protein Complex), EndoV, ERAP1, ERp27, EULIR, FAM162B, FBL17, Fbxo12, Fbxo12J, FBXO21, FBXO38, FBXO41, FBXO48, FBXW10, Fbxw12, Fbxw13, Fbxw16, FBXW17, Fbxw19, FBXW2, FBXW23, FBXW9, G2E3, Gigaxonin, Glomulin, Gm410, Gm514, GMCL1L, GP78-1, H2-Aa, H2-Db, H2-M9, H2-Q1, H2-Q10, H2-Q8, H2-T10, H2-T22, H2-T9, HAPSTR2, HECTD1, HECTD2, HECTD3, HECTD4, Herc1, Herc2, Herc4, Herc6, HES1, HKIB9, HLA-B, HLA-B7, HLA-DX, IDE, Igkv1-117, INTS7, IQCJ, IQUB, ITM2B, Jade-1, Josephin-2, Josephin-3, Kap95, KBTBD11, KBTBD12, KBTBD13, KBTBD4, KBTBD5, KBTBD7, KCMF1, Kex2, KIAA1984, KLHDC10, KLHDC2, KLHDC3, KLHDC4, KLHDC7A, KLHDC7B, KLHDC8B, KLHL32, KLHL33, KLHL35, KLHL8, LANPL, LAP3, Legumain, LOC100040307, LOC728369, LOC728379, LOC728393, LOC728400, LONRF1, LONRF2, LONRF3, LRRC31, LRRC41, LRRC42, LRRC43, LRRC66, LRSAM1, LYZL1, MAGE-L2, Makorin-2, MECL-1, Midline-1, Mill1, Mill2, mKIAA1530, MRFAP1L1, MTP18, MuRF2, murinoglobulin 2, MYEOV2, Ndfip2, NEDL1, NEURL, NEURL4, NHLRC3, NOB1P, Nulp1, OPAL1, ORAOV1, OTC, OTTMUSG00000013284, OTTMUSG00000014862, OTTMUSG00000015173, OTTMUSG00000015220, OTTMUSG00000015279, OTTMUSG00000015337, OTTMUSG00000015417, OTTMUSG00000015643, OTTMUSG00000015752, OTTMUSG00000016293, OTUD2, OTUD6B, OTUD7A, P-Rex2, Paip1, PC5/6, PCIA1, PCID2, Pellino 3, Pi15, PI31, PIH1D2, PJA1, PJA2, PLIC-1, PNAd, PNGase, PNRC2, PRB2, prochymosin, PSMB11, PSMB6, PSMC6, PSMD11, PSMD12, PSMD13, PSMD3, PSMD5, PSMD7, PSMD8, PSME proteasome activator subunits (PA28), Psmg2, PTGES3L-AARSD1, Rad23, Rbx2, Reticulon, Rfp2, RFPL4A, RHBDD1, RHBDL1, RHBDL2, Rhomboid, RING1B, RLIM, RMND5A, RMND5B, RNF103, RNF113A, RNF113A1, RNF113A2, RNF115, RNF121, RNF126, RNF130, RNF133, RNF138, RNF145, RNF148, RNF150, RNF151, RNF152, RNF166, RNF167, RNF180, RNF181, RNF182, RNF183, RNF184, RNF187, RNF214, RNF219, RNF220, RNF222, RNF24, RNF26, RNF32, RNF38, RNF39, RNF44, Rpn11, Rsp5, Rub1, SEC11A, SEL-10, Sel-1L2, Sel-1L3, SerpinA1d, SerpinA3g, SerpinB1b, Serpinb6d, SerpinB6e, SHFM3, Slimb, SPINK10, SPPL2b, STAMBP, SUG1, SVIP, TAPBPL, TEX261, TIP120, TIP120B, TMEM129, TMEM155, TMEM179B, TOPORS, TPCK, TPPII, TRIM11, Trim12c, TRIM23, Trim29, TRIM30B, TRIM31, TRIM37, TRIM40, TRIM41, TRIM43, TRIM43B, TRIM44, TRIM45, TRIM47, TRIM49B, TRIM50, TRIM58, TRIM6, TRIM6-TRIM34, TRIM64B, TRIM64C, TRIM79, TRIP12, TRIP15, UBAP2, UBC, UBC2, UBCE7IP4, UBE1L2, UBE2CBP, UBE2QL1, UBE2Z, UBE3B, UBE3C, UBE4A, UBL7, UBQLN3, UBQLNL, Ubr1, Ubr2, Ubr3, Ubr7, UBTD1, UBTD2, UBXD7, UCH-L1, UFD1, UIP5, USP10, USP17L, USP21, USP26, USP28, USP29, USP41, USP50, UXT, Vrho, Vta1, VWA9, WAC, WDR20a, WDR61, WDYHV1, WFDC17, WSB1, ZFAND1, ZFAND2B, ZFP30, Zimp7, ZNF114, ZNF121, ZNF213, ZNF216, ZNF228, ZNF506, ZSWIM1, ZUFSP, and ZYG11B.Activator of:
β-1,4-GalNAc-T4, 20S Proteasome α1, 20S Proteasome α3, 20S Proteasome α4, 20S Proteasome α5, 20S Proteasome α6, 20S Proteasome α7, 4933402E13Rik, A1Up, ADRM1, APEH, Arkadia, ASB-1, ASB-13, ASB-17, ASB-2, ASB-5, ASB-7, ASB-8, Axotrophin, BTBD14B, BTBD18, CCP2, Cdc34, Cdc34B, CLN1, COP1, CRLF3, CT45-1, CUEDC2, cystatin 11, cystatin B, DCAF16, Dcun1D3, Derlin-3, ECM29, EG229571, Elongin C, ENGase, FBL12, FBL13, FBL3A, FBX23, FBXO11, Fbxo12J, FBXO24, FBXO29, FBXO35, FBXO39, FBXO7, Fbxw13, FBXW17, Fbxw19, Gap 1, Gm514, Herc5, HLA-A2, IFRG15, Josephin-1, KIAA0776, KIAA1468, KLF16, KLHL10, KLHL11, KLHL15, KLHL23, KLHL24, KLHL36, KLHL5, KLHL9, LNX3, LONRF1, MAN1B1, MARCH4, MARCH8, MECL-1, Neuralized-2, Npl4, Nup107, OTUD4, PCNP, PIASy, PLIC-2, POH1, PROS-30, PSMC1, PSMC4, PSMD1, PSMD2, PSMD7, PSMD8, Rad23A, RAI15, Rbx1, RFPL1, RNF122, RNF13, RNF141, RNF149, RNF165, RNF23, RNF4, Rotavirus, Rpn11, SENP8, SIAH3, stefin A1, stefin A2, TAP1, TAP2, TRC8, TRIM42, TRIM54, TRIM7, TRIM75, TRIP12, tsg 101, Ub-RPS27A, UBAP1, UBC12, UBC2, UBE1L, UBE2B, UBE2D1, UBE2E3, UBE2L3, UBE2Q1, UBE2Q2, UBE2QL1, UBE2U, UBE2W, UBE3C, UBL3, UBPY, Ubr1, UBXD4, UBXN2B, UCH-L3, UFD2, USP47, USPL1, v-SNARE Vti1p, VCPIP1, VPS37, and WSB2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Lactacystin, 200 µg | sc-3575 | 200 µg | $165.00 | |||
Lactacystin, 1 mg | sc-3575A | 1 mg | $575.00 |