Molecular structure of Nutlin-3, CAS Number: 548472-68-0
Nutlin-3 (CAS 548472-68-0)
See product citations (24)
Alternate Names:
Nutlin-3 is also known as the p53/MDM2 Agonist.
Application:
Nutlin-3is an apoptosis inducer and disruptor of MDM2-p53 interaction, inhibiting with a IC50 of 0.09 µM.
CAS Number:
548472-68-0
Purity:
≥98%
Molecular Weight:
581.49
Molecular Formula:
C30H30Cl2N4O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
The most used form of nutlin, Nutlin-3 inhibits p53-Mdm2 interaction and the growth of human tumor xenografts in nude mice. Nutlin-3 has shown to induce the expression of p53-regulated genes and exhibits potent antiproliferative activity in cells with functional p53, but not in cells with mutated p53. When Nutlin-3 is in combination with perifosine, anti-leukaemic activity has been observed. High N-Myc (N-Myc) expression has been induced in non-N-MYC-amplified neuroblastoma cells when treated with the combination of Nutlin-3 and doxorubicin (sc-200923).
Nutlin-3 (CAS 548472-68-0) References
- In vivo activation of the p53 pathway by small-molecule antagonists of MDM2. | Vassilev, LT., et al. 2004. Science. 303: 844-8. PMID: 14704432
- Reactivation of the p53 pathway as a treatment modality for KSHV-induced lymphomas. | Sarek, G., et al. 2007. J Clin Invest. 117: 1019-28. PMID: 17364023
- Small-molecule inhibitors of the MDM2-p53 protein-protein interaction to reactivate p53 function: a novel approach for cancer therapy. | Shangary, S. and Wang, S. 2009. Annu Rev Pharmacol Toxicol. 49: 223-41. PMID: 18834305
- A function for the RING finger domain in the allosteric control of MDM2 conformation and activity. | Wawrzynow, B., et al. 2009. J Biol Chem. 284: 11517-30. PMID: 19188367
- Perifosine plus nutlin-3 combination shows a synergistic anti-leukaemic activity. | Voltan, R., et al. 2010. Br J Haematol. 148: 957-61. PMID: 19958355
- Protection of p53 wild type cells from taxol by nutlin-3 in the combined lung cancer treatment. | Tokalov, SV. and Abolmaali, ND. 2010. BMC Cancer. 10: 57. PMID: 20178585
- Inactivation of p53 signaling by p73 or PTEN ablation results in a transformed phenotype that remains susceptible to Nutlin-3 mediated apoptosis. | Cipriano, R., et al. 2010. Cell Cycle. 9: 1373-9. PMID: 20305378
- Nutlin-3 induces HO-1 expression by activating JNK in a transcription-independent manner of p53. | Choe, YJ., et al. 2014. Int J Oncol. 44: 761-8. PMID: 24366007
- Nutlin-3 induces BCL2A1 expression by activating ELK1 through the mitochondrial p53-ROS-ERK1/2 pathway. | Lee, SY., et al. 2014. Int J Oncol. 45: 675-82. PMID: 24867259
- Nutlin-3 sensitizes nasopharyngeal carcinoma cells to cisplatin-induced cytotoxicity. | Voon, YL., et al. 2015. Oncol Rep. 34: 1692-700. PMID: 26252575
- Oridonin synergizes with Nutlin-3 in osteosarcoma cells by modulating the levels of multiple Bcl-2 family proteins. | Wang, XH., et al. 2017. Tumour Biol. 39: 1010428317701638. PMID: 28618955
- Synergistic effect of Nutlin-3 combined with MG-132 on schwannoma cells through restoration of merlin and p53 tumour suppressors. | Chen, H., et al. 2018. EBioMedicine. 36: 252-265. PMID: 30274821
- Resistance of human primary mesenchymal stem cells to cytotoxic effects of nutlin-3 in vitro. | Bajelan, B., et al. 2020. J Cell Biochem. 121: 788-796. PMID: 31452266
Inhibitor of:
ΔN p63, 1700065O13Rik, 1700066B19Rik, 1700066C05Rik, 2510049J12Rik, 3830417A13Rik, 4921511H03Rik, 4930422I07Rik, 4930430D24Rik, 4930435E12Rik, 4930546H06Rik, 4931440F15Rik, 4933402E13Rik, 4933403O08Rik, 4933439F11Rik, 53BP2, A1-c, Abp ζ, ALS2CR4, ANKRD31, ANKRD38, ARID1A, ASB-11, AVEN, BANP, BAT2L, BAT3, BC057079, BCLAF1, BEAN, Bex4, Bles03, BNIPL-2, Brp16, BTBD12, BTG4, C10orf46, C10orf71_3425401B19Rik, C12orf24, C12orf34, C14orf131, C14orf56, C17orf47, C17orf89, C19orf39, C22orf31, C2orf15, C2orf29_D1Bwg0212e, C3orf24, C9orf25, C9orf30_5730528L13Rik, Cactin, Cardiotrophin-1, CBLL1, CCDC16, CCDC41, CCDC6, Cdc27, Cdk11, CDKN2AIPNL, Cdt2, cep-1, CHD (chromodomain helicase), CHD7, Cig2, CKAP2, CNOT2, CRF21, Crk I, CTGLF6, CUEDC1, CUL-3, CUL-4B, DCAMKL2, Dcun1D4, DEPDC1B, DFF-45, DMRTC1, Dmrtc1b, DR1, DTX3L, DUX5, dystrotelin, E2F-6, E47, ECOP, EG236663, EG545802, EG546325, EG666209, EHZF, EndoV, EWS, F8A2, FAM111A, FAM131B, FAM131C, FAM195A, FAM196B, Fbxo12, Fbxo12J, FBXO38, FBXW10, Fbxw13, Fbxw16, FBXW17, FBXW18, Fbxw19, Fbxw21, FBXW24, FBXW28, FBXW5, FBXW9, fizzy-related protein, FLJ10357, FLJ13611, FOP, FOXK1, FOXR2, GAGE12C, GBDR1, GCFC1, GDF-8, Gm44, Gm757, GTPBP4, H2-M11, Hct1, HEATR7A, HECTD3, HELZ, Herc4, HIC-1, HORMAD2, HoxB13, HoxD4, HSFY2, HSPC038, Hus1B, IBRDC1, IBRDC2, ING1, ING3, INSM1, JTB, KIAA1462, KLHDC5, KLHL38, KLHL6, KRBA2, KRBOX1, LARP6, LHX1, Limd2, Lin-7Bb, LIN-9, Lipocalin-11, LNX2, LOC100039815, LOC100039946, LOC100040524, LOC100041238, LOC100041280, LOC100041317, LOC285191, LOC342918, LOC644695, LOC646012, LOC729729, LOC729886, LOC730018, LRIG2, LYAR, LZIC, MAGE, MAGE-A10, MAGE-A12, MAGE-A8, MAGE-B10, MAGE-B17, MAGE-G1, Makorin-2, Max, MDM-2, MDM2, Mi2-β, Midline-2, MSP58, MTBP, NARF, NBPF14, NBPF16, NBPF3, NCYM, Ndn, Npl1, Olr264, P15RS, p19 ARF, P2P-R, p53, p53RFP, p73β, PCDH7, Pcdhb22, PCDHGA7_Pcdhga7, PCDHGB5, Pegasus, PIERCE 1, PIG3, PLAC8, Polyoma virus large T antigen, POU2F3, PRAC, PRAME like-3, PRAME like-6, PRAMEF12, PRAMEF16, PRAMEF24, Pramel, PRAP1, PROS-30, PRR15, PRUNE2, QPCTL, R3HDM1, Ran BP-2, Rasl2-9, RASSF2, Rb, RBBP9, RBM46, RBM47, RBPMS2, RBQ-1, RBQ-3, Rbx1, Reprimo, RFC5, Rfp2, RFPL4A, RGAG4, RGPD7, Rhox3c, Rif1, RMND5A, RNF10, RNF113B, RNF126, RNF133, RNF150, RNF165, RNF17, RNF175, RNF184, RNF186, RNF23, RNF26, RNF38, RNF39, RNF6, Rslcan-11, SAPS2, Scand3, SCAPER, SCYL1BP1, SEBOX, SERTAD2, Skeletrophin, Skp2 p45, SLBP, Smac, SNAP 29, SNARK, SorCS3, SPANX-5, SPANX-A, SPANX-A-F, SPANX-E, SPANX-N2, SPINK12, SSH3, SSX2-IP, TBRG4, TERF1P2, TEX16, TEX19.1, TEX22, TMEM14C, Toso, TP53INP2, TP53TG5, Transcription Factor, TRIM17, TRIM2, TRIM26, TRIM36, TRIM4, TRIM43A, TRIM44, TRIM58, TRIM59, TSPY, TUSC1, TUSC2, TXNDC15, UBE1L, UBE2H, UBE2Q1, UBE3C, Ubr7, UBTD1, UBTFL1, USP53, VCX-A, VCX-B1, VDAC3, VE-cadherin-2, WDR40C, WDR62, WDR76, XAGE-1C, XAGE-3, XAGE2B, Xlr3b, YPEL3, ZAR1L, ZBTB1, ZBTB25, ZBTB34, ZBTB8, ZEB2, ZFP3, ZFP319, Zic1, Zimp10, ZNF169, ZNF175, ZNF185, ZNF189, ZNF200, ZNF207, ZNF286, ZNF300, ZNF318, ZNF345, ZNF362, ZNF385C, ZNF397, ZNF41, ZNF452, ZNF454, ZNF512B, ZNF553, ZNF570, ZNF597, ZNF620, ZNF644, ZNF645, ZNF674, ZNF691, ZNF705D, ZNF709, ZNF79, ZNF8, ZNF806, ZNF836, ZNF841, ZNF844, ZNF853, ZNHIT6, ZSCAN18, ZSCAN2, ZSWIM7, ZYG11B, and ZZEF1.Activator of:
ASB-13, ASB-17, ASB-5, ASCC1, ATDC, B23, BC061212, BCL2L12, Bex2, BRIP1, C20orf112, CARF, Cdc34, Cdc4, Cdc6, CDIP, CED-9, CEP72, Ctdp1, CUL-7, DEDD2, Diva, DNA pol λ, DUB3, E2F-3, EG408191, EG621697, EI24, Elongin C, FBXO30, FEM1B, FLASH, FRMD6, FXR1, GCIP, HSP 75, ING4, INTS4, JKTBP, JMY, LARP7, LATS2, LOC641776, LOC643909, MARCH6, MCAF2, MDM-2, MDMX, Mxi1, MYBBP1A, Nucleostemin, Nup155, p107, p19, p53AIP1, p53CSV, p53R2, p55 CDC, Pdcd2L, Perp, pescadillo, PGBD1, PIG-U, PIG11, PRDM5, PTα, PUMA, RAB3IP, RFPL2, Ribosomal Protein S5, Ribosomal Protein S6, RNF149, RNF220, RNF25, RNF4, RYBP, SELH, SENP2, SIAH3, SID-1, SMC1α, ST7, SUMO-2, TIP120A, TIPIN, TP53TG3, TP53TG5, TRIAD1, TRIM49, UBE2E3, UBE2J1, UBE2W, Ubr3, v-SNARE Vti1p, VPRBP, WDR48, Wee 1, Wig-1, Wip1, YPEL, ZW10, and Zwilch.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Nutlin-3, 1 mg | sc-45061 | 1 mg | $62.00 | |||
Nutlin-3, 5 mg | sc-45061A | 5 mg | $225.00 | |||
Nutlin-3, 25 mg | sc-45061B | 25 mg | $779.00 |