RNF150 Activators
RNF150 Activators refers to compounds that indirectly enhance the functional activity of RNF150, a protein involved in ubiquitination and proteasomal degradation. These activators do not directly interact with RNF150 but influence cellular pathways and processes that indirectly necessitate or enhance the ubiquitin ligase activity of RNF150. For instance, compounds like EGF and PMA activate signaling pathways (EGFR and PKC, respectively) that affect cellular processes involving protein regulation, leading to increased demand for RNF150's ubiquitin ligase function. EGF, through its effect on the EGFR pathway, alters downstream signaling cascades, indirectly necessitating enhanced RNF150 activity for protein ubiquitination and regulation.
Similarly,LY294002 and Rapamycin, targeting the PI3K/AKT/mTOR and mTOR pathways respectively, influence cell growth and proliferation. The inhibition of these pathways can lead to alterations in protein turnover, increasing the requirement for RNF150's role in protein ubiquitination and degradation. Forskolin, through its activation of adenylyl cyclase and subsequent elevation of cAMP levels, affects various signaling pathways. This alteration in cellular signaling dynamics could enhance the demand for RNF150-mediated ubiquitination in regulating protein function. Ionomycin, by increasing intracellular calcium levels, influences pathways such as NF-κB signaling, which can modulate protein degradation pathways, indirectly enhancing RNF150's function in ubiquitin-mediated degradation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA is known to activate Protein Kinase C (PKC), which is involved in a wide range of cellular processes including cell cycle regulation and apoptosis. PKC activation can lead to changes in cellular signaling that may require increased ubiquitination activity, potentially enhancing RNF150 function. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylyl cyclase, leading to an increase in cAMP levels. Elevated cAMP can affect various signaling pathways, potentially increasing the demand for ubiquitination and degradation of regulatory proteins, indirectly enhancing RNF150's ubiquitin ligase activity. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular calcium levels, influencing pathways like NF-κB signaling. This alteration can modulate protein degradation pathways, indirectly enhancing RNF150's role in ubiquitin-mediated degradation. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin can modulate various signaling pathways, including those involved in inflammation and apoptosis. By altering these pathways, curcumin may indirectly enhance RNF150 activity, as changes in cellular signaling could necessitate increased ubiquitination and proteasomal activity. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor that affects the PI3K/AKT/mTOR pathway. Inhibition of this pathway can lead to changes in cellular signaling dynamics, potentially enhancing RNF150's role in protein ubiquitination and degradation. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin is an mTOR inhibitor that affects cell growth and proliferation pathways. Inhibition of mTOR signaling can lead to alterations in protein turnover and degradation, potentially necessitating enhanced RNF150 activity in protein ubiquitination. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is a p38 MAPK inhibitor. Inhibition of the p38 MAPK pathway can alter cellular stress responses and apoptosis signaling, potentially increasing the need for RNF150-mediated ubiquitination in protein regulation. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is another MEK inhibitor affecting the MAPK/ERK pathway. By modulating this pathway, it could indirectly enhance the activity of RNF150, as altered signaling dynamics may increase the requirement for ubiquitin-mediated protein regulation. | ||||||
BAY 11-7082 | 19542-67-7 | sc-200615B sc-200615 sc-200615A | 5 mg 10 mg 50 mg | $61.00 $83.00 $349.00 | 155 | |
BAY 11-7082 inhibits NF-κB activation, which can affect various cellular processes including inflammation and cell survival. This inhibition might enhance RNF150 activity indirectly by altering the ubiquitination and degradation patterns of proteins involved in these pathways. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is a JNK inhibitor that affects stress response and apoptosis pathways. Inhibiting JNK signaling could indirectly enhance RNF150's activity, as changes in cellular signaling may necessitate increased ubiquitin ligase function. | ||||||