Rad23A Inhibitors
Rad23A inhibitors are a class of chemical compounds designed to target and inhibit the function of Rad23A, a protein involved in DNA repair and protein degradation pathways. Rad23A plays a critical role in the nucleotide excision repair (NER) mechanism, where it helps recognize and repair damaged DNA by interacting with other repair proteins. Additionally, Rad23A is involved in the ubiquitin-proteasome system (UPS), where it functions as a ubiquitin receptor that helps shuttle polyubiquitinated proteins to the proteasome for degradation. By inhibiting Rad23A, these compounds can interfere with both the repair of damaged DNA and the regulated degradation of proteins, making Rad23A a central player in maintaining cellular homeostasis.
Chemically, Rad23A inhibitors are designed to target specific domains of the protein, such as its ubiquitin-associated (UBA) domains or ubiquitin-like (UBL) domain. These domains are essential for Rad23A's interactions with polyubiquitinated proteins and other components of the DNA repair and degradation machinery. Inhibitors may act by binding to these domains, preventing Rad23A from performing its role in substrate recognition or protein-protein interactions. Structure-based drug design and high-throughput screening are typically used to identify and optimize inhibitors that selectively target Rad23A without affecting related proteins. By inhibiting Rad23A, researchers can study its involvement in DNA repair processes, protein degradation pathways, and how its inhibition affects cellular responses to DNA damage and protein turnover. These inhibitors serve as valuable tools for understanding the molecular mechanisms of Rad23A in regulating genomic stability and protein quality control within the cell.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin may downregulate RAD23A transcription by altering the activity of specific transcription factors or by changing the methylation status of the RAD23A promoter region. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol has the potential to decrease RAD23A expression through the inhibition of transcription factor binding or by inducing histone modifications at the RAD23A gene locus. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin could reduce RAD23A mRNA levels by inhibiting kinase enzymes that are upstream of the transcriptional machinery responsible for RAD23A gene expression. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid can lead to the reduced expression of RAD23A by binding to retinoic acid receptors that interact with the RAD23A gene promoter, thereby repressing its transcription. | ||||||
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $51.00 $231.00 $523.00 | 63 | |
Etoposide may inhibit RAD23A expression by inducing DNA strand breaks and triggering a DNA damage response that can lead to the repression of non-essential DNA repair genes, including RAD23A. | ||||||
Fluorouracil | 51-21-8 | sc-29060 sc-29060A | 1 g 5 g | $37.00 $152.00 | 11 | |
By inhibiting thymidylate synthase, 5-Fluorouracil causes DNA damage and may lead to a decrease in RAD23A expression as part of the cellular response to genotoxic stress. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin can inhibit RAD23A protein synthesis by directly inhibiting the mTOR pathway, which is critical for cap-dependent translation initiation of many mRNAs, including RAD23A. | ||||||
Doxorubicin | 23214-92-8 | sc-280681 sc-280681A | 1 mg 5 mg | $176.00 $426.00 | 43 | |
Doxorubicin can downregulate RAD23A expression through DNA intercalation and inhibition of topoisomerase II, which can prompt a reduction in the transcription of certain repair genes. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
Sodium butyrate can decrease RAD23A expression by inhibiting histone deacetylases, which increases acetylation of histones and alters the expression of specific genes including RAD23A. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 may lead to the reduced expression of RAD23A by inhibiting PI3K, thereby obstructing the AKT signaling pathway that is involved in the transcription of RAD23A. | ||||||