Rad23A Activators are chemical compounds that directly or indirectly stimulate the functional activity of Rad23A, which is a key player in the proteasome pathway. Rad23A acts as a shuttle protein, participating in the delivery ofubiquitinated proteins to the proteasome for degradation. This set of compounds primarily consists of proteasome inhibitors, which act by impeding the degradation of ubiquitinated proteins. By inhibiting the proteasome, these compounds effectively increase the workload for Rad23A, amplifying its protein delivery function and thus enhancing its activity. Examples of these compounds include MG-132, Lactacystin, and Bortezomib, all of which are potent proteasome inhibitors that can lead to an accumulation of ubiquitinated proteins, necessitating a greater involvement of Rad23A in protein trafficking.
The proteasome inhibitors that act as Rad23A activators are structurally diverse, ranging from peptide aldehydes (MG-132) to β-lactones (Lactacystin) and boronic acids (Bortezomib). Despite their structural differences, these compounds share a common mechanism of action: they inhibit the proteolytic activities of the proteasome, leading to an accumulation of ubiquitinated proteins. This accumulation enhances the role of Rad23A in protein delivery to the proteasome. Other proteasome inhibitors such as Carfilzomib, Marizomib, and Ixazomib follow a similar mechanism of action. They block the degradation of ubiquitinated proteins, thereby indirectly enhancing the functional activity of Rad23A. The collective action of these Rad23A activators underscores the importance of the proteasome pathway and Rad23A's role within it, offering valuable insights into the cellular processes of protein degradation and recycling.
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Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
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MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $56.00 $260.00 $980.00 | 163 | |
MG-132 is a potent, reversible proteasome inhibitor. It acts by preventing the degradation of ubiquitinated proteins. Rad23A, as a component of the proteasome pathway, is involved in the delivery of ubiquitinated proteins to the proteasome. Therefore, the use of MG-132 can lead to an accumulation of ubiquitinated proteins, enhancing the function of Rad23A in protein trafficking. | ||||||
Lactacystin | 133343-34-7 | sc-3575 sc-3575A | 200 µg 1 mg | $165.00 $575.00 | 60 | |
Lactacystin is a specific inhibitor of the proteasome. By inhibiting the proteasome, it prevents the degradation of ubiquitinated proteins and enhances the delivery function of Rad23A by increasing the need for protein trafficking. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $132.00 $1064.00 | 115 | |
Bortezomib is a selective inhibitor of the 26S proteasome. By inhibiting the proteasome, it increases the demand for Rad23A's protein delivery function, thus enhancing its activity. | ||||||
Epoxomicin | 134381-21-8 | sc-201298C sc-201298 sc-201298A sc-201298B | 50 µg 100 µg 250 µg 500 µg | $134.00 $215.00 $440.00 $496.00 | 19 | |
Epoxomicin is a selective proteasome inhibitor. It inhibits the degradation of ubiquitinated proteins, thus enhancing Rad23A's role in protein delivery to the proteasome. | ||||||
Carfilzomib | 868540-17-4 | sc-396755 | 5 mg | $40.00 | ||
Carfilzomib is a selective proteasome inhibitor. It prevents the degradation of ubiquitinated proteins, enhancing Rad23A's role in protein delivery to the proteasome. | ||||||
Ixazomib | 1072833-77-2 | sc-489103 sc-489103A | 10 mg 50 mg | $311.00 $719.00 | ||
Ixazomib is a selective inhibitor of the 26S proteasome. By inhibiting the proteasome, it increases the demand for Rad23A's protein delivery function, thus enhancing its activity. | ||||||
Oprozomib | 935888-69-0 | sc-477447 | 2.5 mg | $280.00 | ||
Oprozomib is a proteasome inhibitor. It acts by preventing the degradation of ubiquitinated proteins. As a result, the function of Rad23A in the delivery of ubiquitinated proteins to the proteasome is enhanced. | ||||||
Delanzomib, free base | 847499-27-8 | sc-396774 sc-396774A | 5 mg 10 mg | $160.00 $300.00 | ||
Delanzomib is a selective proteasome inhibitor. It prevents the degradation of ubiquitinated proteins, enhancing Rad23A's role in protein delivery to the proteasome. |