Date published: 2025-10-23

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Rad23A Activators

Rad23A Activators are chemical compounds that directly or indirectly stimulate the functional activity of Rad23A, which is a key player in the proteasome pathway. Rad23A acts as a shuttle protein, participating in the delivery ofubiquitinated proteins to the proteasome for degradation. This set of compounds primarily consists of proteasome inhibitors, which act by impeding the degradation of ubiquitinated proteins. By inhibiting the proteasome, these compounds effectively increase the workload for Rad23A, amplifying its protein delivery function and thus enhancing its activity. Examples of these compounds include MG-132, Lactacystin, and Bortezomib, all of which are potent proteasome inhibitors that can lead to an accumulation of ubiquitinated proteins, necessitating a greater involvement of Rad23A in protein trafficking.

The proteasome inhibitors that act as Rad23A activators are structurally diverse, ranging from peptide aldehydes (MG-132) to β-lactones (Lactacystin) and boronic acids (Bortezomib). Despite their structural differences, these compounds share a common mechanism of action: they inhibit the proteolytic activities of the proteasome, leading to an accumulation of ubiquitinated proteins. This accumulation enhances the role of Rad23A in protein delivery to the proteasome. Other proteasome inhibitors such as Carfilzomib, Marizomib, and Ixazomib follow a similar mechanism of action. They block the degradation of ubiquitinated proteins, thereby indirectly enhancing the functional activity of Rad23A. The collective action of these Rad23A activators underscores the importance of the proteasome pathway and Rad23A's role within it, offering valuable insights into the cellular processes of protein degradation and recycling.

SEE ALSO...

Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

MG-132 [Z-Leu- Leu-Leu-CHO]

133407-82-6sc-201270
sc-201270A
sc-201270B
5 mg
25 mg
100 mg
$56.00
$260.00
$980.00
163
(3)

MG-132 is a potent, reversible proteasome inhibitor. It acts by preventing the degradation of ubiquitinated proteins. Rad23A, as a component of the proteasome pathway, is involved in the delivery of ubiquitinated proteins to the proteasome. Therefore, the use of MG-132 can lead to an accumulation of ubiquitinated proteins, enhancing the function of Rad23A in protein trafficking.

Lactacystin

133343-34-7sc-3575
sc-3575A
200 µg
1 mg
$165.00
$575.00
60
(2)

Lactacystin is a specific inhibitor of the proteasome. By inhibiting the proteasome, it prevents the degradation of ubiquitinated proteins and enhances the delivery function of Rad23A by increasing the need for protein trafficking.

Bortezomib

179324-69-7sc-217785
sc-217785A
2.5 mg
25 mg
$132.00
$1064.00
115
(2)

Bortezomib is a selective inhibitor of the 26S proteasome. By inhibiting the proteasome, it increases the demand for Rad23A's protein delivery function, thus enhancing its activity.

Epoxomicin

134381-21-8sc-201298C
sc-201298
sc-201298A
sc-201298B
50 µg
100 µg
250 µg
500 µg
$134.00
$215.00
$440.00
$496.00
19
(2)

Epoxomicin is a selective proteasome inhibitor. It inhibits the degradation of ubiquitinated proteins, thus enhancing Rad23A's role in protein delivery to the proteasome.

Carfilzomib

868540-17-4sc-396755
5 mg
$40.00
(0)

Carfilzomib is a selective proteasome inhibitor. It prevents the degradation of ubiquitinated proteins, enhancing Rad23A's role in protein delivery to the proteasome.

Ixazomib

1072833-77-2sc-489103
sc-489103A
10 mg
50 mg
$311.00
$719.00
(0)

Ixazomib is a selective inhibitor of the 26S proteasome. By inhibiting the proteasome, it increases the demand for Rad23A's protein delivery function, thus enhancing its activity.

Oprozomib

935888-69-0sc-477447
2.5 mg
$280.00
(0)

Oprozomib is a proteasome inhibitor. It acts by preventing the degradation of ubiquitinated proteins. As a result, the function of Rad23A in the delivery of ubiquitinated proteins to the proteasome is enhanced.

Delanzomib, free base

847499-27-8sc-396774
sc-396774A
5 mg
10 mg
$160.00
$300.00
(0)

Delanzomib is a selective proteasome inhibitor. It prevents the degradation of ubiquitinated proteins, enhancing Rad23A's role in protein delivery to the proteasome.