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MG-132 [Z-Leu- Leu-Leu-CHO] (CAS 133407-82-6)

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Alternate Names:
MG-132 [Z-Leu- Leu-Leu-CHO] also known as (S)-MG132; Z-LLL-al; Carbobenzoxy-L-leucyl-L-leucyl-L-leucinal; N-CBZ-leucine-leucine-leucinal; Z-Leu-Leu-Leu-CHO; Z-Leu-Leu-Leu-al; MG132; MG-132; S)-MG132
Application:
MG-132 [Z-Leu- Leu-Leu-CHO] is a proteasome and NF-κB inhibitor which is used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins
CAS Number:
133407-82-6
Purity:
>98%
Molecular Weight:
475.62
Molecular Formula:
C26H41N3O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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MG-132 [Z-Leu- Leu-Leu-CHO] is a potent, reversible, and cell-permeable proteasome inhibitor. MG-132 [Z-Leu- Leu-Leu-CHO] is used as a tool for perturbing the proteasome-regulated degradation of intracellular proteins. These proteins processed by the proteasome are involved in inflammatory processes and cell cycle regulation, presenting broad relevance for aldehydic proteasome inhibitors of this type. For instance, MG-132 [Z-Leu- Leu-Leu-CHO] suppresses NF-kappaB activation (at 10 muM) by preventing IkappaB degradation (IC50=3 muM), which blocks the transcription factor from providing chemoresistance to cancer cells. Also, MG-132 [Z-Leu- Leu-Leu-CHO] may act to prevent beta-secretase cleavage of amyloid precursor protein (APP). Additionally, MG-132 [Z-Leu- Leu-Leu-CHO] is an inhibitor of 26S Proteasome and calpain, as well as, an activator of JNK1, c-Jun and c-Fos.Related products include sc-351846 (sc-351846).


MG-132 [Z-Leu- Leu-Leu-CHO] (CAS 133407-82-6) References

  1. The protease inhibitor, MG132, blocks maturation of the amyloid precursor protein Swedish mutant preventing cleavage by beta-Secretase.  |  Steinhilb, ML., et al. 2001. J Biol Chem. 276: 4476-84. PMID: 11084038
  2. Inhibition of NF-kappaB sensitizes human pancreatic carcinoma cells to apoptosis induced by etoposide (VP16) or doxorubicin.  |  Arlt, A., et al. 2001. Oncogene. 20: 859-68. PMID: 11314019
  3. Proteasome inhibition: a new anti-inflammatory strategy.  |  Elliott, PJ., et al. 2003. J Mol Med (Berl). 81: 235-45. PMID: 12700891
  4. Synthesis, radiosynthesis, and biological evaluation of new proteasome inhibitors in a tumor targeting approach.  |  Vivier, M., et al. 2008. J Med Chem. 51: 1043-7. PMID: 18237109
  5. [Effect of proteasome inhibitor MG-132 on L1210 cell apoptosis and its mechanism].  |  Li, XH., et al. 2010. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 18: 321-5. PMID: 20416160
  6. DJ-1 protein protects dopaminergic neurons against 6-OHDA/MG-132-induced neurotoxicity in rats.  |  Sun, SY., et al. 2012. Brain Res Bull. 88: 609-16. PMID: 22664331
  7. Proteasome inhibitor MG-132 induces MCPIP1 expression.  |  Skalniak, L., et al. 2013. FEBS J. 280: 2665-74. PMID: 23551903
  8. The role of Src protein in the process formation of PC12 cells induced by the proteasome inhibitor MG-132.  |  Tarjányi, O., et al. 2013. Neurochem Int. 63: 413-22. PMID: 23911694
  9. Coxsackievirus-induced miR-21 disrupts cardiomyocyte interactions via the downregulation of intercalated disk components.  |  Ye, X., et al. 2014. PLoS Pathog. 10: e1004070. PMID: 24722419
  10. Nigrostriatal pathway degeneration in rats after intraperitoneal administration of proteasome inhibitor MG-132.  |  Wójcik, S., et al. 2014. Folia Neuropathol. 52: 41-55. PMID: 24729342
  11. MCPIP1 contributes to the toxicity of proteasome inhibitor MG-132 in HeLa cells by the inhibition of NF-κB.  |  Skalniak, L., et al. 2014. Mol Cell Biochem. 395: 253-63. PMID: 24992982
  12. Upregulated ROS production induced by the proteasome inhibitor MG-132 on XBP1 gene expression and cell apoptosis in Tca-8113 cells.  |  Chen, HY., et al. 2014. Biomed Pharmacother. 68: 709-13. PMID: 25092240
  13. Chemically assisted somatic cell nuclear transfer without micromanipulator in the goat: effects of demecolcine, cytochalasin-B, and MG-132 on the efficiency of a manual method of oocyte enucleation using a pulled Pasteur pipette.  |  Hosseini, SM., et al. 2015. Anim Reprod Sci. 158: 11-8. PMID: 25956201
  14. Inhibition of autophagy promotes cell apoptosis induced by the proteasome inhibitor MG-132 in human esophageal squamous cell carcinoma EC9706 cells.  |  Liu, D., et al. 2015. Oncol Lett. 9: 2278-2282. PMID: 26137056
  15. Proteasome inhibitors: valuable new tools for cell biologists.  |  Lee, DH. and Goldberg, AL. 1998. Trends Cell Biol. 8: 397-403. PMID: 9789328

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

MG-132 [Z-Leu- Leu-Leu-CHO], 5 mg

sc-201270
5 mg
$60.00

MG-132 [Z-Leu- Leu-Leu-CHO], 25 mg

sc-201270A
25 mg
$265.00

MG-132 [Z-Leu- Leu-Leu-CHO], 100 mg

sc-201270B
100 mg
$1000.00