Quercetin, one of the main flavonoids that exists in galangal (Zingiberaceae), is a hydroxylated flavanoid that has been shown to cause potent reversible inhibition of fatty-acid synthase. It possesses potential antiinflammatory properties. Quercetin also inhibits Trk (tyrosine protein kinase), phospholipase A2, PDE (phosphodiesterases), mitochondrial ATPase, PI 3-kinase and PKC (protein kinase C). It has been reported that the competitive inhibition of FASN by quercetin leads to apoptotic cell death which results in inhibition of cell proliferation. Quercetin also behaves as a GPR30 activator and calcium channel protein inhibitor.
1. Li, B.H. and Tian, W.X. 2003. J Enzyme Inhib Med Chem. 18: 349-356. PMID: 14567550 2. Lupu, R. and Menendez, J.A. 2006. Curr Pharm Biotechnol. 7: 483-493. PMID: 17168665 3. Tiong, K.H., et al. 2010. Xenobiotica. 40: 458-466. PMID: 20402563
Soluble in DMSO (30 mg/ml), DMF (~30 mg/ml), and ethanol (~2 mg/ml).
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Tiong et alTiong et al. (PubMed ID 20402563) found that quercetin competitively inhibited Coumarin 7-hydroxylase activity via cytochrome P450 2A6 (CYP2A6). -SCBT Publication Review
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