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Doxorubicin (CAS 23214-92-8)

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Alternate Names:
Adriamycin
Application:
Doxorubicin is an immunosuppresive antineoplastic antibiotic
CAS Number:
23214-92-8
Purity:
≥95%
Molecular Weight:
543.52
Molecular Formula:
C27H29NO11
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Doxorubicin is a compound extensively studied in the field of biochemistry and molecular biology, particularly for its ability to intercalate DNA. Research involving doxorubicin focuses on its interaction with nucleic acids and the subsequent effects on cellular replication processes. It is used to elucidate the molecular mechanisms of DNA intercalation, topoisomerase inhibition, and the generation of free radicals—processes that are fundamental to understanding cell cycle regulation and apoptosis. In addition, doxorubicin is useful in the study of chemical-DNA binding kinetics and the development of novel chemical delivery systems aimed at improving the efficiency of targeting specific cells. Studies on the photophysical properties of doxorubicin contribute to the advancement of fluorescence microscopy techniques, enhancing the visualization of cellular and molecular interactions.


Doxorubicin (CAS 23214-92-8) References

  1. Doxorubicin degradation in cardiomyocytes.  |  Menna, P., et al. 2007. J Pharmacol Exp Ther. 322: 408-19. PMID: 17468298
  2. An overview of doxorubicin formulations in cancer therapy.  |  Rivankar, S. 2014. J Cancer Res Ther. 10: 853-8. PMID: 25579518
  3. Rutin attenuates doxorubicin-induced cardiotoxicity via regulating autophagy and apoptosis.  |  Ma, Y., et al. 2017. Biochim Biophys Acta Mol Basis Dis. 1863: 1904-1911. PMID: 28069395
  4. Long-Circulating Amphiphilic Doxorubicin for Tumor Mitochondria-Specific Targeting.  |  Xi, J., et al. 2018. ACS Appl Mater Interfaces. 10: 43482-43492. PMID: 30479120
  5. Doxorubicin contributes to thrombus formation and vascular injury by interfering with platelet function.  |  Lv, H., et al. 2020. Am J Physiol Heart Circ Physiol. 319: H133-H143. PMID: 32469636
  6. Phenylboronic acid-functionalized F127-oligochitosan conjugate micelles for doxorubicin encapsulation.  |  Feng, R., et al. 2020. J Biomed Mater Res B Appl Biomater. 108: 3345-3355. PMID: 32583518
  7. Preclinical Study of Pharmacological Properties of Doxorubicin-NPh.  |  Nemtsova, ER., et al. 2020. Bull Exp Biol Med. 169: 778-782. PMID: 33123920
  8. A switch in mechanism of action prevents doxorubicin-mediated cardiac damage.  |  Cheong, A., et al. 2021. Biochem Pharmacol. 185: 114410. PMID: 33428897
  9. Impact of ellagic acid application on doxorubicin-induced cardiovascular toxicity model.  |  Salinger-Martinovic, S., et al. 2021. Can J Physiol Pharmacol. 99: 185-191. PMID: 33509026
  10. Repeated Remote Ischemic Conditioning Reduces Doxorubicin-Induced Cardiotoxicity.  |  He, Q., et al. 2020. JACC CardioOncol. 2: 41-52. PMID: 34396208
  11. Effects of Melatonin and Doxorubicin on Primary Tumor And Metastasis in Breast Cancer Model.  |  Tanriover, G., et al. 2022. Anticancer Agents Med Chem. 22: 1970-1983. PMID: 34961467
  12. SIRT1 in the cardiomyocyte counteracts doxorubicin-induced cardiotoxicity via regulating histone H2AX.  |  Kuno, A., et al. 2023. Cardiovasc Res. 118: 3360-3373. PMID: 35258628
  13. Reversal of Doxorubicin-Induced Bone Loss and Mineralization by Supplementation of Resveratrol and MitoTEMPO in the Early Development of Sparus aurata.  |  Poudel, S., et al. 2022. Nutrients. 14: PMID: 35334811
  14. Effect of Chloroquine on Doxorubicin-induced Apoptosis in A549 Cells.  |  Sato, K., et al. 2022. Anticancer Res. 42: 4025-4035. PMID: 35896249
  15. Spectroscopy studies of interaction hypericin with an anti-cancer therapy drug doxorubicin.  |  Pietrzak, M., et al. 2022. Biophys Chem. 288: 106858. PMID: 35905651

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Doxorubicin, 1 mg

sc-280681
1 mg
$173.00

Doxorubicin, 5 mg

sc-280681A
5 mg
$418.00

Dear All We kindly ask to obtain a new offer for the following items: 1.Doxorubicin 2.Losartan 3.Talabostat

Asked by: Noha
Please contact your local distributor or our Customer Service team for more information. https://www.scbt.com/resources/distributors
Answered by: Tech Sales
Date published: 2021-06-25

How long is a doxorubicin solution (in water) stable at 4°C? Unfortunately it precipitates as soon as I dilute it in Cell Culture Media. Do you have an advice for how to avoid such problem?

Asked by: JC92
Highly concentrated solutions of doxorubicin are prone to precipitation, which is why they are best prepared within 12-24 hours before they are used in a given experiment. Due to the solubility of doxorubicin being 10x higher in DMSO than in water, you might consider switching to this solvent instead.
Answered by: SCBT Heidelberg Support
Date published: 2018-12-30

Density?

Asked by: mar90
Thank you for your question. The predicted density value for this product is 1.6g/cm3. If you have any further questions, please contact our European Technical Service team. You can reach them by phone at Toll Free: +49 6221 4503 0, by email at: europe@scbt.com or by live chat directly on our website, www.scbt.com
Answered by: Tech Service
Date published: 2017-06-06
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Rated 5 out of 5 by from A VERY GOOD PRODUCTPMID 25837271 USED THIS PRODUCT. IT IS A VERY GOOD PRODUCT.
Date published: 2017-05-23
Rated 5 out of 5 by from A VERY GOOD PRODUCTI USED IT IN MY MANUSCRIPT. IT IS A VERY GOOD PRODUCT.
Date published: 2017-04-04
Rated 5 out of 5 by from Varga et alVarga et al. (PubMed ID 26386112) used doxorubicin to induce mitochondrial-related cytotoxicity. -SCBT Publication Review
Date published: 2015-05-01
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Doxorubicin is rated 5.0 out of 5 by 3.
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