Date published: 2025-11-1

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p53 Antibodies

Santa Cruz Biotechnology supplies a comprehensive collection of p53 monoclonal antibodies, essential tools for researchers studying the pivotal role of p53 in cellular processes. p53 monoclonal antibodies excel in various techniques, including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), flow cytometry (FCM), and enzyme-linked immunosorbent assay (ELISA). p53, often referred to as the "guardian of the genome," is crucial for regulating the cell cycle and preventing tumor formation. It functions as a transcription factor that responds to cellular stress and DNA damage, initiating repair processes or triggering apoptosis when necessary. Given its significant role in cancer biology, understanding p53 dynamics is vital for developing targeted therapies and improving cancer treatment outcomes. p53 monoclonal antibodies enable precise detection and analysis of p53 expression patterns across different cell types and conditions. Researchers can investigate p53 activation, regulation, and interaction with other molecules using specific detection methods. p53 monoclonal antibodies support detailed examination of mutations and modifications that affect p53 function in various cancers. Santa Cruz Biotechnology p53 monoclonal antibodies empower researchers worldwide to advance cancer research and contribute to developing more effective therapeutic strategies.

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p53 Antibodies

Empty Table HeaderProduct NameCATALOG #ISOTYPEEPITOPEAPPLICATIONSSpeciesCitationsRATING

p53 Antibody (DO-1)

sc-126mouse IgG2a κ11-25 (h)WB, IP, IF, IHC(P), FCMm, r, h
6,657
(184)

p53 Antibody (Pab 240)

sc-99mouse IgG1 κ213-217 (h)WB, IP, IFm, r, h
473
(21)

p53 Antibody (DO-7)

sc-47698mouse IgG2b κ1-45, 20-25 (epitope mapped) (h)WB, IP, IF, IHC(P), FCMh
253
(30)

p53 Antibody (A-1)

sc-393031mouse IgG1 κ353-391 (r)WB, IP, IF, ELISAm, r, h
65
(30)

p53 Antibody (Pab 1801)

sc-98mouse IgG1 κ32-79 (h)WB, IP, IF, IHC(P), FCMm, r, h
411
(18)

p53 Antibody (Bp53-12)

sc-263mouse IgG2a κ16-25 (h)WB, IP, IF, IHC(P), ELISAm, r, h
203
(10)

p53 Antibody (Pab 246)

sc-100mouse IgG1 κ88-93 (m)WB, IP, IFm, r
104
(9)

p53 Antibody (C-11)

sc-55476mouse IgG1 κFL (h)WB, IP, IF, ELISAm, r, h
54
(6)

p53 Antibody (DO-2)

sc-53394mouse IgG1 κ10-16 (h)WB, IP, IF, IHC(P)m, r, h
32
(5)

p53 Antibody (D-11)

sc-17846mouse IgG1 κFL (h)WB, IP, IF, ELISAm, r, h
16
(4)

p53 Antibody (pAb 122)

sc-56182mouse IgG2b370-378 (m)WB, IP, IF, FCMm, r, h
12
(3)

p53 Antibody (2B2.68)

sc-71817mouse IgG2a κ11-25 (h)WB, IP, IF, IHC(P), FCMh
23
(3)

p53 Antibody (B-P3)

sc-65334mouse IgG2a κ16-25 (h)WB, IP, IF, IHC(P), ELISAm, r, h
13
(3)

p53 Antibody (BP 53.12)

sc-81168mouse IgG2a κN-Terminal (h)WB, IP, IF, IHC(P)h
27
(3)

p53 Antibody (BP 53.122)

sc-73566mouse IgG2a κ16-25 (h)WB, IP, IF, IHC(P), ELISAm, r, h
9
(2)

p53 Antibody (3H2821)

sc-56179mouse IgG1 κ(m)WB, IP, IFm, r
10
(2)

p53 Antibody (2Q366)

sc-71818mouse IgG2b370-378 (m)WB, IP, IF, FCMm, r, h
8
(3)

p53 Antibody (2B2.71)

sc-71819mouse IgG2b370-378 (m)WB, IP, IF, FCMm, r, h
11
(2)

p53 Antibody (F-8)

sc-374087mouse IgG1 κ367-390 (m)WB, IP, IF, ELISAm, r, h
5
(2)

p53 Antibody (3H2821)

sc-71815mouse IgG1 κ(m)WB, IP, IFm
2
(1)

p53 Antibody (2Q375)

sc-71820mouse IgG1(h)WB, IP, IF, IHC(P)m, r, h
11
(2)

Phospho-Specific p53 Antibodies

Empty Table HeaderProduct NameCATALOG #ISOTYPEEPITOPEAPPLICATIONSSpeciesCitationsRATING

p-p53 Antibody (D-9)

sc-377567mouse IgM κThr 155 (h)WB, IP, IF, IHC(P), ELISAh
20
(13)

p-p53 Antibody (B-12)

sc-377564mouse IgG1 κThr 155 (h)WB, IP, IF, ELISAh

new

(2)

p-p53 Antibody (B-3)

sc-377553mouse IgG1 κ51-60 (h)WB, IP, IF, IHC(P), ELISAh
2
(5)

p-p53 Antibody (59.Ser 315)

sc-135772mouse IgG2a κSer 315 (h)WB, IP, ELISAh
7
(6)

p-p53 Antibody (F-11)

sc-377561mouse IgG1 κ42-51 (h)WB, IP, IF, ELISAh
2
(4)

p-p53 Antibody (FP3.2)

sc-51690mouse IgG1 κ78-393 (h)WB, IP, IF, IHC(P), ELISAm, r, h
17
(14)

p-p53 Antibody (FPS392)

sc-56173mouse IgG1380-393 (h)WB, IP, IF, IHC(P), ELISAm, r, h, porcine and canine
6
(2)

p-p53 Antibody (3H2806)

sc-71786mouse IgG1378-393 (h)WB, IP, IF, IHC(P), ELISAm, r, h, porcine and canine
5
(2)

Non-Mammalian p53 Antibodies

Empty Table HeaderProduct NameCATALOG #ISOTYPEEPITOPEAPPLICATIONSSpeciesCitationsRATING

p53 Antibody (C-11)

sc-74574mouse IgG2a κ186-385 (Drosophila melanogaster)WB, IP, IF, ELISAd
4
(1)

p53 Antibody (E-5)

sc-74573mouse IgG2a κ186-385 (Drosophila melanogaster)WB, IP, IF, ELISAd
3
(1)

p53 CRISPR Knockout, HDR and Double Nickase Plasmids

Empty Table HeaderProduct NameCATALOG #SpeciesAPPLICATIONSMARKERCitationsRATING

p53 CRISPR/Cas9 KO Plasmid (h)

sc-416469hGene KnockoutGFP
27
(1)

p53 HDR Plasmid (h)

sc-416469-HDRhHomology Directed RepairPuromycin
27
(1)

p53 Double Nickase Plasmid (h)

sc-416469-NIChGene KnockoutPuromycin
27
(1)

p53 Double Nickase Plasmid (h2)

sc-416469-NIC-2hGene KnockoutPuromycin
27
(1)

p53 Double Nickase Plasmid (m)

sc-423509-NICmGene KnockoutPuromycin
1
(1)

p53 Double Nickase Plasmid (m2)

sc-423509-NIC-2mGene KnockoutPuromycin
1
(1)

p53 CRISPR/Cas9 KO Plasmid (r)

sc-437318rGene KnockoutGFP0
(0)

p53 HDR Plasmid (r)

sc-437318-HDRrHomology Directed RepairPuromycin0
(0)

p53 Double Nickase Plasmid (r)

sc-437318-NICrGene KnockoutPuromycin0
(0)

p53 Double Nickase Plasmid (r2)

sc-437318-NIC-2rGene KnockoutPuromycin0
(0)

p53 CRISPR Activation Products

Empty Table HeaderProduct NameCATALOG #SpeciesAPPLICATIONSMARKERCitationsRATING

p53 CRISPR Activation Plasmid (h)

sc-416469-ACThGene ActivationPuro, Blast, Hygro
27
(1)

p53 CRISPR Activation Plasmid (h2)

sc-416469-ACT-2hGene ActivationPuro, Blast, Hygro
27
(1)

p53 Lentiviral Activation Particles (h)

sc-416469-LAChGene ActivationPuro, Blast, Hygro
27
(1)

p53 Lentiviral Activation Particles (h2)

sc-416469-LAC-2hGene ActivationPuro, Blast, Hygro
27
(1)

p53 CRISPR Activation Plasmid (m)

sc-423509-ACTmGene ActivationPuro, Blast, Hygro
1
(1)

p53 CRISPR Activation Plasmid (m2)

sc-423509-ACT-2mGene ActivationPuro, Blast, Hygro
1
(1)

p53 Lentiviral Activation Particles (m)

sc-423509-LACmGene ActivationPuro, Blast, Hygro
1
(1)

p53 Lentiviral Activation Particles (m2)

sc-423509-LAC-2mGene ActivationPuro, Blast, Hygro
1
(1)

p53 CRISPR Activation Plasmid (r)

sc-437318-ACTrGene ActivationPuro, Blast, Hygro0
(0)

p53 CRISPR Activation Plasmid (r2)

sc-437318-ACT-2rGene ActivationPuro, Blast, Hygro0
(0)

p53 Lentiviral Activation Particles (r)

sc-437318-LACrGene ActivationPuro, Blast, Hygro0
(0)

p53 Lentiviral Activation Particles (r2)

sc-437318-LAC-2rGene ActivationPuro, Blast, Hygro0
(0)

p53 siRNA, shRNA Plasmid and shRNA Lentiviral Particle Gene Silencers

Empty Table HeaderProduct NameCATALOG #SpeciesAPPLICATIONSMARKERCitationsRATING

p53 siRNA (h)

sc-29435hGene SilencingN/A
353
(1)

p53 siRNA (h2)

sc-44218hGene SilencingN/A
15
(0)

p53 shRNA Plasmid (h)

sc-29435-SHhGene SilencingPuromycin
353
(1)

p53 shRNA Plasmid (h2)

sc-44218-SHhGene SilencingPuromycin
15
(0)

p53 shRNA (h) Lentiviral Particles

sc-29435-VhGene SilencingPuromycin
353
(1)

p53 shRNA (h2) Lentiviral Particles

sc-44218-VhGene SilencingPuromycin
15
(0)

p53 siRNA (m)

sc-29436mGene SilencingN/A
60
(1)

p53 siRNA (m2)

sc-44219mGene SilencingN/A
3
(0)

p53 shRNA Plasmid (m)

sc-29436-SHmGene SilencingPuromycin
60
(1)

p53 shRNA Plasmid (m2)

sc-44219-SHmGene SilencingPuromycin
3
(0)

p53 shRNA (m) Lentiviral Particles

sc-29436-VmGene SilencingPuromycin
60
(1)

p53 shRNA (m2) Lentiviral Particles

sc-44219-VmGene SilencingPuromycin
3
(0)

p53 siRNA (r)

sc-45917rGene SilencingN/A
12
(0)

p53 shRNA Plasmid (r)

sc-45917-SHrGene SilencingPuromycin
12
(0)

p53 shRNA (r) Lentiviral Particles

sc-45917-VrGene SilencingPuromycin
12
(0)

p53 Transfected Lysates

Empty Table HeaderProduct NameCATALOG #SpeciesCONTROL ANTIBODYCitationsRATING

p53 (m): 293T Lysate

sc-125766m
2
(0)

p53 (h3): 293T Lysate

sc-158802h30
(0)

p53 Proteins

Empty Table HeaderProduct NameCATALOG #AmountSpeciesCitationsRATING

p53 (1-393)

sc-424650 µgh
28
(0)

p53 Oligonucleotides

Empty Table HeaderProduct NameCONSENSUS CAT. #MUTANT CAT. #MUTANT CONSENSUSBINDING MOTIFCitationsRATING

p53 consensus oligonucleotide

sc-2579sc-25805'-TAC AGA ACA TGT CTA AGC ATG CTG GGG-3'"CATG"→"TCGC"
59
(0)