p-p53 Antibody (FPS392): sc-56173

p-p53 Antibody (FPS392) is a mouse monoclonal IgG1 antibody that detects p53 in mouse, rat, human, porcine, and canine samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). p-p53 monoclonal antibody (FPS392) specifically recognizes the phosphorylated form of p53, a crucial tumor suppressor protein that plays a vital role in cellular responses to stress, including DNA damage. The phosphorylation of p53 enhances stability and transcriptional activity, allowing effective regulation of genes involved in cell cycle arrest and apoptosis. This post-translational modification is essential for p53 activation in response to cellular stress signals, ensuring damaged cells do not proliferate, which is a key mechanism in preventing tumorigenesis. Furthermore, p53′s ability to form tetramers and dynamic conformational changes are influenced by these phosphorylation events, underscoring the importance of post-translational modifications in functional regulation. With broad species reactivity and versatility in various applications, anti-p53 antibody (FPS392) is an invaluable tool for researchers studying p53′s intricate roles in cancer biology and cellular stress responses.

The preferred p53 antibody is p53 Antibody (DO-1): sc-126.