NOS1 Inhibitors
Santa Cruz Biotechnology now offers a broad range of NOS1 Inhibitors. Nitric oxide (NO) has a broad range of biological activities including cell signaling pathways in phylogenetically diverse species. Nitric oxide synthases (NOSs), the enzymes responsible for synthesis of NO, contain an N-terminal oxygenase domain and a C-terminal reductase domain. NOS1 (also designated ncNOS) is a constitutive Ca2+/CaM-dependent form of NOS, whose activity was first identified in neurons. NOS1 Inhibitors offered by Santa Cruz inhibit NOS1 and, in some cases, other cell signaling and nitric oxide synthesis related proteins. View detailed NOS1 Inhibitor specifications, including NOS1 Inhibitor CAS number, molecular weight, molecular formula and chemical structure, by clicking on the product name.
Items 1 to 10 of 54 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
L-NG-Nitroarginine Methyl Ester (L-NAME) | 51298-62-5 | sc-200333 sc-200333A sc-200333B | 1 g 5 g 25 g | $47.00 $105.00 $322.00 | 45 | |
L-NAME is a non-selective NOS inhibitor, which can inhibit NOS1 activity leading to reduced NO production. | ||||||
L-NG-Monomethylarginine, Acetate Salt (L-NMMA) | 53308-83-1 | sc-200739 sc-200739A sc-200739B sc-200739C | 25 mg 100 mg 1 g 100 g | $73.00 $224.00 $663.00 $39586.00 | 3 | |
L-NMMA is a non-selective NOS inhibitor that can inhibit NOS1 among other isoforms. | ||||||
Melatonin | 73-31-4 | sc-207848 sc-207848A sc-207848B sc-207848C sc-207848D sc-207848E | 1 g 5 g 25 g 100 g 250 g 1 kg | $64.00 $72.00 $214.00 $683.00 $1173.00 $3504.00 | 16 | |
Melatonin, a potent regulator of circadian rhythms, exhibits unique interactions with nitric oxide synthase (NOS) through its indole structure, which facilitates binding to the enzyme's active site. This binding modulates NOS activity, influencing nitric oxide levels. Additionally, melatonin's lipophilic nature allows it to traverse cellular membranes easily, enhancing its bioavailability. Its antioxidant properties further contribute to its role in cellular signaling and protection against oxidative stress. | ||||||
S-Methyl-L thiocitrulline, Dihydrochloride | 209589-59-3 | sc-3571 | 10 mg | $56.00 | 1 | |
SMTC selectively targets NOS1, leading to reduced NO production in neurons. | ||||||
Bromocriptine mesylate | 22260-51-1 | sc-200395 sc-200395A sc-200395B | 100 mg 500 mg 1 g | $98.00 $362.00 $540.00 | 4 | |
Bromocriptine mesylate, a dopamine agonist, engages with nitric oxide synthase (NOS1) through specific conformational changes in the enzyme's structure. This interaction alters the enzyme's kinetics, potentially enhancing nitric oxide production. The compound's unique hydrophilic and lipophilic balance allows it to interact with various cellular environments, facilitating its penetration into lipid membranes. Its distinct molecular interactions may influence downstream signaling pathways, contributing to diverse physiological effects. | ||||||
7-Ethoxyresorufin | 5725-91-7 | sc-200606 sc-200606A | 2 mg 10 mg | $135.00 $265.00 | 6 | |
7-Ethoxyresorufin is a selective substrate for nitric oxide synthase (NOS1), exhibiting unique binding dynamics that enhance its catalytic efficiency. Its structure allows for specific interactions with the enzyme's active site, promoting electron transfer and influencing reaction kinetics. The compound's hydrophobic characteristics facilitate its integration into lipid bilayers, potentially modulating membrane-associated processes. This specificity in molecular interactions may lead to distinct regulatory effects on nitric oxide signaling pathways. | ||||||
Chlorpromazine, Hydrochloride | 69-09-0 | sc-202537 sc-202537A sc-202537B sc-202537C sc-202537D | 500 mg 5 g 25 g 100 g 250 g | $39.00 $55.00 $149.00 $496.00 $1087.00 | 7 | |
Chlorpromazine, Hydrochloride interacts with nitric oxide synthase (NOS1) through unique conformational changes that enhance substrate affinity. Its aromatic structure allows for π-π stacking interactions, stabilizing enzyme-substrate complexes. The compound's amphipathic nature promotes its localization within cellular membranes, potentially influencing lipid dynamics and protein interactions. This behavior may alter NOS1 activity, impacting downstream signaling cascades in cellular environments. | ||||||
Gallotannin | 1401-55-4 | sc-202619 sc-202619A sc-202619B sc-202619C sc-202619D sc-202619E sc-202619F | 1 g 10 g 100 g 250 g 1 kg 2.5 kg 5 kg | $25.00 $36.00 $66.00 $76.00 $229.00 $525.00 $964.00 | 12 | |
Gallotannin exhibits intriguing interactions with nitric oxide synthase (NOS1) by forming hydrogen bonds with key amino acid residues, which can modulate enzyme activity. Its polyphenolic structure facilitates electron transfer processes, enhancing the enzyme's catalytic efficiency. Additionally, gallotannin's ability to chelate metal ions may influence the redox state of NOS1, potentially altering its functional dynamics and affecting nitric oxide production pathways in various biological contexts. | ||||||
Zinc Protoporphyrin-9 | 15442-64-5 | sc-200329 sc-200329A | 25 mg 100 mg | $76.00 $209.00 | 31 | |
Zinc Protoporphyrin-9 interacts with nitric oxide synthase (NOS1) through its unique coordination with the heme group, influencing the enzyme's conformation and activity. Its rigid structure allows for specific steric interactions that can modulate substrate binding. The presence of zinc enhances the stability of the enzyme, while its porphyrin ring facilitates electron delocalization, impacting reaction kinetics and the overall efficiency of nitric oxide synthesis in cellular processes. | ||||||
Aminoguanidine hydrochloride | 1937-19-5 | sc-202931 sc-202931A sc-202931B | 10 g 25 g 50 g | $31.00 $42.00 $92.00 | 2 | |
Although a broad NOS inhibitor, aminoguanidine can inhibit NOS1 activity in specific contexts. | ||||||