Molecular structure of Zinc Protoporphyrin-9, CAS Number: 15442-64-5
Zinc Protoporphyrin-9 (CAS 15442-64-5)
See product citations (31)
Alternate Names:
Zinc Protoporphyrin-9 is also known as ZINC (II) Protoporphyrin IX.
Application:
Zinc Protoporphyrin-9 is a potent, selective inhibitor of heme oxygenase, GCS, NOS1, NOS2, and NOS3.
CAS Number:
15442-64-5
Molecular Weight:
626.05
Molecular Formula:
C34H32N4O4Zn
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Zinc protoporphyrin-9 is a potent, selective inhibitor of heme oxygenase (Ki=3 nM). Carbon monoxide (CO) is an activator of guanylate cyclase that is produced in vivo via the action of heme oxygenase. Zinc Protoporphyrin-9 has recently been used to block CO biosynthesis and thereby lower cGMP concentrations in olfactory neuronal cultures. It is an extremely useful tool to elucidate the role of CO in signal transduction and as a neurotransmitter. Zinc Protoporphyrin-9 is classified as an endogenous metabolite.
Zinc Protoporphyrin-9 (CAS 15442-64-5) References
- Zinc protoporphyrin: A metabolite with a mission. | Labbé, RF., et al. 1999. Clin Chem. 45: 2060-72. PMID: 10585337
- Zinc Protoporphyrin-9 Potentiates the Anticancer Activity of Dihydroartemisinin. | Zhang, Y., et al. 2023. Antioxidants (Basel). 12: PMID: 36829809
- Inhibition by zinc protoporphyrin-IX of receptor-mediated relaxation of the rat aorta in a manner distinct from inhibition of haem oxygenase. | Ny, L., et al. 1995. Br J Pharmacol. 115: 186-90. PMID: 7647974
- The role of carbon monoxide in lucigenin-dependent chemiluminescence of rat alveolar macrophages. | Fukushima, T., et al. 1995. Eur J Pharmacol. 289: 103-7. PMID: 7781703
- Carbon monoxide as a novel neuroendocrine modulator: inhibition of stimulated corticotropin-releasing hormone release from acute rat hypothalamic explants. | Pozzoli, G., et al. 1994. Endocrinology. 135: 2314-7. PMID: 7988414
- Gases as biological messengers: nitric oxide and carbon monoxide in the brain. | Dawson, TM. and Snyder, SH. 1994. J Neurosci. 14: 5147-59. PMID: 8083727
- Nitric oxide and carbon monoxide produce activity-dependent long-term synaptic enhancement in hippocampus. | Zhuo, M., et al. 1993. Science. 260: 1946-50. PMID: 8100368
- Does endogenous zinc protoporphyrin modulate carbon monoxide formation from heme? Implications for long-term potentiation, memory, and cognitive function. | Marks, GS., et al. 1993. Can J Physiol Pharmacol. 71: 753-4. PMID: 8143232
- Inhibition of nitric oxide synthase isoforms by porphyrins. | Wolff, DJ., et al. 1996. Arch Biochem Biophys. 333: 27-34. PMID: 8806750
- Oxytocin release is inhibited by the generation of carbon monoxide from the rat hypothalamus--further evidence for carbon monoxide as a neuromodulator. | Kostoglou-Athanassiou, I., et al. 1996. Brain Res Mol Brain Res. 42: 301-6. PMID: 9013787
- Induction of heme oxygenase-1 expression in vascular smooth muscle cells. A link to endotoxic shock. | Yet, SF., et al. 1997. J Biol Chem. 272: 4295-301. PMID: 9020147
- Evidence that carbon monoxide stimulates prostaglandin endoperoxide synthase activity in rat hypothalamic explants and in primary cultures of rat hypothalamic astrocytes. | Mancuso, C., et al. 1997. Brain Res Mol Brain Res. 45: 294-300. PMID: 9149104
- Pitfalls using metalloporphyrins in carbon monoxide research. | Grundemar, L. and Ny, L. 1997. Trends Pharmacol Sci. 18: 193-5. PMID: 9226997
- Effect of heme oxygenase inhibitors on soluble guanylyl cyclase activity. | Serfass, L. and Burstyn, JN. 1998. Arch Biochem Biophys. 359: 8-16. PMID: 9799554
- Mechanism of inhibition of VIP-induced LES relaxation by heme oxygenase inhibitor zinc protoporphyrin IX. | Rattan, S., et al. 1999. Am J Physiol. 276: G138-45. PMID: 9886989
Inhibitor of:
GCS, Heme Oxygenase, Hephaestin, NOS, NOS1, NOS2, and NOS3.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Zinc Protoporphyrin-9, 25 mg | sc-200329 | 25 mg | $76.00 | |||
Zinc Protoporphyrin-9, 100 mg | sc-200329A | 100 mg | $209.00 |