Molecular structure of L-NG-Nitroarginine Methyl Ester (L-NAME), CAS Number: 51298-62-5
L-NG-Nitroarginine Methyl Ester (L-NAME) (CAS 51298-62-5)
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Alternate Names:
L-NAME HCl;H-Arg(NO2)-OMe HCl;N-Nitro-L-arginine methyl ester hydrochloride
Application:
L-NG-Nitroarginine Methyl Ester (L-NAME) is a precursor to NOS inhibitor, L-NNA - requires bioactivation to become a fully functional inhibitor
CAS Number:
51298-62-5
Purity:
≥98%
Molecular Weight:
269.69
Molecular Formula:
C7H15N5O4•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
L-NG-Nitroarginine Methyl Ester (L-NAME) requires hydrolysis of the methyl ester by cellular esterases to become a fully functional inhibitor (L-NNA). L-NAME exhibits some selectivity for inhibition of NOS. It exhibits Ki values of 15 nM, 39 nM, and 4.4 muM for NOS1 (nNOS) (bovine), NOS3 (eNOS) (human), and NOS2 (iNOS) (mouse), respectively. The reported Ki value for the inhibition of NOS2 ranges from 4-65 muM. L-NAME inhibits cGMP formation in endothelial cells with an IC50 of 3.1 muM (in the presence of 30 muM arginine) and reverses the vasodilation effects of acetylcholine in rat aorta rings with an EC50 of 0.54 muM.
L-NG-Nitroarginine Methyl Ester (L-NAME) (CAS 51298-62-5) References
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Inhibitor of:
β-defensin 131, AGAT, ANXA8L2, ASL, AtNOS1, C4orf14, CAT-1, D-GPCR, DCST1, dystrophin, EG667094, EG667472, GABA T-2, GC kinase, GCS-α-1, GCS-β-1, GPR112, GPR176, Guanylate Cyclase (GUCA), LCE3C, MAS1, melanopsin, MrgA5, MUP13, MUP14, NEPH3, NOS, NOS1, NOS3, NOSIP, NPFF, NPFF1 Receptor, NrCAM, Olfr1055, Olfr1115, Olfr360, Olfr446, Olfr747, Olfr805, OPN1MW2, OR1A2, OR1D5, OR4C46, OR5B3, OR5M3, PDP2, PSD2, RhBG, SAHH-3, sGC α1, sGC α2I, sGC β2, SPR, V1RB2, V1RB9, V1rg10, V1RI4, Vmn1r126, Vmn1r128, Vmn1r139, Vmn1r143, Vmn1r149, Vmn1r155, Vmn2r102, Vmn2r116, Vmn2r18, Vmn2r73, and Vmn2r96.Activator of:
1110049F12Rik, 1500009C09Rik, 1700006E09Rik, 2700078E11Rik, 2810405K02Rik, 3200002M19Rik, Basonuclin 2, BC055111, C11orf74, CD101, DPY19L2, FAM75A2, GAP1m, GATA-4, GPR108, GPR111, GPR115, GPR50, HOP-1, MUM1L1, NMUR2, NPY2-R, Olfr1029, Olfr297, RGS10, RGS11, RGS18, RNF11, ROM1, TTP-αL, UBAP2, urocortin III, urotensin IIB, USP24, USP36, and VIT32.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
L-NG-Nitroarginine Methyl Ester (L-NAME), 1 g | sc-200333 | 1 g | $48.00 | |||
L-NG-Nitroarginine Methyl Ester (L-NAME), 5 g | sc-200333A | 5 g | $107.00 | |||
L-NG-Nitroarginine Methyl Ester (L-NAME), 25 g | sc-200333B | 25 g | $328.00 |