Molecular structure of Aminoguanidine hydrochloride, CAS Number: 1937-19-5
Aminoguanidine hydrochloride (CAS 1937-19-5)
See product citations (2)
Alternate Names:
Hydrazinecarboximidamide, monohydrochloride; Guanylhydrazine hydrochloride; GER 11
Application:
Aminoguanidine hydrochloride is an irreversible and selective inhibitor of NOS2
CAS Number:
1937-19-5
Molecular Weight:
110.55
Molecular Formula:
CH6N4•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Aminoguanidine hydrochloride is a chemical compound frequently used in research applications as a selective inhibitor of nitric oxide synthase, which plays a significant role in the study of cellular signaling pathways. In biochemistry, it is utilized to understand the effects of nitric oxide in various biological systems, such as its role in neurotransmission and the immune response. Additionally, aminoguanidine hydrochloride serves as a key reagent in the synthesis of heterocyclic compounds, which are of interest for their potential applications in new material development. In analytical chemistry, this compound is used to trap reactive carbonyl species, facilitating the study of non-enzymatic protein glycation and the effects of aging and oxidative stress on cellular components.
Aminoguanidine hydrochloride (CAS 1937-19-5) References
- Protein glycation, diabetes, and aging. | Ulrich, P. and Cerami, A. 2001. Recent Prog Horm Res. 56: 1-21. PMID: 11237208
- Protective effect of aminoguanidine upon capillary and submesothelial anionic sites. | Shostak, A., et al. 2001. Microvasc Res. 61: 166-78. PMID: 11254396
- Interaction of inducible nitric oxide synthase and cyclooxygenase-2 inhibitors in formalin-induced nociception in mice. | Dudhgaonkar, SP., et al. 2004. Eur J Pharmacol. 492: 117-22. PMID: 15178354
- Synergistic anti-inflammatory interaction between meloxicam and aminoguanidine hydrochloride in carrageenan-induced acute inflammation in rats. | Dudhgaonkar, SP., et al. 2006. Life Sci. 78: 1044-8. PMID: 16109432
- Synthesis of 2-(1,5-diaryl-1,4-pentadien-3-ylidene)-hydrazinecarboximidamide hydrochloride catalyzed by p-dodecylbenzenesulfonic acid in aqueous media under ultrasound irradiation. | Li, JT., et al. 2012. Ultrason Sonochem. 19: 1033-8. PMID: 22440718
- Synthesis and Anticancer Activities of Novel Guanylhydrazone and Aminoguanidine Tetrahydropyran Derivatives. | Silva, FP., et al. 2016. Molecules. 21: PMID: 27338323
- Evidence for the involvement of TNF-α, IL-1β and IL-10 in the antinociceptive and anti-inflammatory effects of indole-3-guanylhydrazone hydrochloride, an aromatic aminoguanidine, in rodents. | Sandes, SMS., et al. 2018. Chem Biol Interact. 286: 1-10. PMID: 29499192
- Recyclable deep eutectic solvent for the production of cationic nanocelluloses. | Li, P., et al. 2018. Carbohydr Polym. 199: 219-227. PMID: 30143124
- Methylglyoxal stimulates endoplasmic reticulum stress in vascular smooth muscle cells. | Kırça, M. and Yeşilkaya, A. 2022. J Recept Signal Transduct Res. 42: 279-284. PMID: 33896363
- Histological assessment of the local effect of different concentrations of aminoguanidine hydrochloride on bone healing in rats. | Farhad, AR., et al. 2021. Dent Res J (Isfahan). 18: 63. PMID: 34584641
- New compounds from Patrinia villosa Juss. and their anti-inflammatory activities. | Huang, LY., et al. 2023. Nat Prod Res. 37: 2189-2197. PMID: 35109740
- Synthesis of 3-(5-amino-1H-1,2,4-triazol-3-yl)propanamides and their tautomerism. | Lim, FPL., et al. 2018. RSC Adv. 8: 22351-22360. PMID: 35539716
- 3-Arylcoumarin inhibits vascular calcification by inhibiting the generation of AGEs and anti-oxidative stress. | Li, Y., et al. 2022. J Enzyme Inhib Med Chem. 37: 2147-2157. PMID: 35950567
Inhibitor of:
4833422F24Rik, AZ1, COL19A1, Doxl2, FN3KRP, NOS1, NOS2, and RAGE.Activator of:
CAPON, and EG627853.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Aminoguanidine hydrochloride, 10 g | sc-202931 | 10 g | $31.00 | |||
Aminoguanidine hydrochloride, 25 g | sc-202931A | 25 g | $42.00 | |||
Aminoguanidine hydrochloride, 50 g | sc-202931B | 50 g | $92.00 |