Molecular structure of Gallotannin, CAS Number: 1401-55-4
Gallotannin (CAS 1401-55-4)
See product citations (12)
Alternate Names:
Tannic acid; Tannin; Digallic Acid; Gallotannic Acid
Application:
Gallotannin is an inhibitor of NOS3 and a weak inhibitor of NOS2 and NOS1
CAS Number:
1401-55-4
Purity:
≥95%
Molecular Weight:
1701.20
Molecular Formula:
C76H52O46
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Gallotannin is an inhibitor of PARG (poly(ADP-ribose) glycohydrolase). Gallotannin is cytoprotective in oxidatively stressed cells. Gallotannin is an inhibitor of NOS3 (eNOS) and a weak inhibitor of NOS2 (iNOS) and NOS1 (nNOS). Gallotannin induces Cox-2 (cyclooxygenase-2) expression and is a free radical scavenger.
Gallotannin (CAS 1401-55-4) References
- Green tea polyphenols and tannic acid act as potent inhibitors of phorbol ester-induced nitric oxide generation in rat hepatocytes independent of their antioxidant properties. | Srivastava, RC., et al. 2000. Cancer Lett. 153: 1-5. PMID: 10779623
- The poly(ADP-ribose) glycohydrolase inhibitor gallotannin blocks oxidative astrocyte death. | Ying, W. and Swanson, RA. 2000. Neuroreport. 11: 1385-8. PMID: 10841343
- Inhibition of poly(ADP-ribose) glycohydrolase by gallotannin selectively up-regulates expression of proinflammatory genes. | Rapizzi, E., et al. 2004. Mol Pharmacol. 66: 890-8. PMID: 15229295
- Enzymology of gallotannin and ellagitannin biosynthesis. | Niemetz, R. and Gross, GG. 2005. Phytochemistry. 66: 2001-11. PMID: 16153405
- Prominent free radicals scavenging activity of tannic acid in lead-induced oxidative stress in experimental mice. | El-Sayed, IH., et al. 2006. Toxicol Ind Health. 22: 157-63. PMID: 16786837
- The efficacy of protective effects of tannic acid, gallic acid, ellagic acid, and propyl gallate against hydrogen peroxide-induced oxidative stress and DNA damages in IMR-90 cells. | Chen, CH., et al. 2007. Mol Nutr Food Res. 51: 962-8. PMID: 17628875
- Efflux-pump inhibitory activity of a gallotannin from Terminalia chebula fruit against multidrug-resistant uropathogenic Escherichia coli. | Bag, A. and Chattopadhyay, RR. 2014. Nat Prod Res. 28: 1280-3. PMID: 24620744
- Computational prediction integrating the inhibition kinetics of gallotannin on α-glucosidase. | Yue, LM., et al. 2017. Int J Biol Macromol. 103: 829-838. PMID: 28539267
- Gallotannin Improves the Photoaged-Related Proteins by Extracellular Signal-Regulated Kinases/c-Jun N-Terminal Kinases Signaling Pathway in Human Epidermal Keratinocyte Cells. | Ryeom, GGM., et al. 2018. J Med Food. 21: 785-792. PMID: 30004816
- Gallotannin 1,2,6-tri-O-galloyl-β-d-glucopyranose: Its availability and changing patterns in tea (Camellia sinensis). | Wei, K., et al. 2019. Food Chem. 296: 40-46. PMID: 31202304
- Recent Advances in Tannic Acid (Gallotannin) Anticancer Activities and Drug Delivery Systems for Efficacy Improvement; A Comprehensive Review. | A Youness, R., et al. 2021. Molecules. 26: PMID: 33803294
- Inhibitory Effect of Gallotannin on Lung Metastasis of Metastatic Colorectal Cancer Cells by Inducing Apoptosis, Cell Cycle Arrest and Autophagy. | Mun, JG., et al. 2021. Am J Chin Med. 49: 1535-1555. PMID: 34247563
- Synthesis and Evaluation of Gallotannin Derivatives as Antioxidants and α-Glucosidase Inhibitors. | Machida, S., et al. 2021. Chem Pharm Bull (Tokyo). 69: 1209-1212. PMID: 34853289
- Inhibition of constitutive endothelial NO-synthase activity by tannin and quercetin. | Chiesi, M. and Schwaller, R. 1995. Biochem Pharmacol. 49: 495-501. PMID: 7532940
Inhibitor of:
αC-crystallin, κ-casein, 4930444G20Rik, 4933425L06Rik, AAT-1, ABC-A1, ACBD7, Aflatoxin B2, AFX1, AI747448, Amisyn, AP-2α, APOBEC1, AQP0, AQP12B, AQP3, AQP5, AQP8, ART2B, ART3, ASIC1, AUP1, Bestrophin-3, BST-1, C1QBP, Cdt1, CES7, ChM-1, CLC-4, CLCA2, Clca6, CLIC3, CLIC6, Clusterin-L1, COL1A2, COL4A1, connexin 25, connexin 40.1, cystatin 11, Cytokeratin 8, EG665927, FITC, FLJ13611, FOXD4L1-6, Galactose Mutarotase, GSTM6, GSTO1, GSTO2, Hephaestin, HFE, HHV-8 K-bZIP, hornerin, IRP-2, KRTAP10-12, KRTAP12-2, KRTAP6-1, LRRC8B, LRRC8C, LRRN1, mito293Tndrial ferritin, mitoNEET, NADK, NF-H, NMNAT-3, NOS, NOS1, NOS2, NOS3, NRF-1, Olfr1084, Olfr332, PANK1, PARG, PCNA, PRL-1, RCK, RDH11, RhBG, RNase 4, RNase L, Rotavirus, SCD2, SERCA2, SERCA3, SKI-1, SLC26A8, SLC26A9, Smt3, SRF, SUMO-4, TCP-1 ζ, TFIIIC63, TMEM16C, TMEM16E, TMEM16F, TMEM16H, TMEM16J, TMPRSSs8, Transketolase, UGTREL1, VDAC1, and ZNHIT6.Activator of:
26S Proteasome, 4930428D18Rik, AI747448, ALDH1A3, AOS-1, Bestrophin-1, Bikunin, CLC-KB, COL14A1, COL18A1, CST9L, DNA pol ε, DNAH7, FBXO3, Klkb1, KRTAP1-1, mito293Tndrial ferritin, NHP2, PIG-M, Proteassemblin, PSMC1, Reg lllα, RTCD1, SERCA1, Tel1, and UBA2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Gallotannin, 1 g | sc-202619 | 1 g | $26.00 | |||
Gallotannin, 10 g | sc-202619A | 10 g | $37.00 | |||
Gallotannin, 100 g | sc-202619B | 100 g | $67.00 | |||
Gallotannin, 250 g | sc-202619C | 250 g | $78.00 | |||
Gallotannin, 1 kg | sc-202619D | 1 kg | $234.00 | |||
Gallotannin, 2.5 kg | sc-202619E | 2.5 kg | $536.00 | |||
Gallotannin, 5 kg | sc-202619F | 5 kg | $983.00 |